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    Natural Products
    Cycloart-22-ene-3,25-diol
    Information
    CAS No. 97456-49-0 Price
    Catalog No.CFN97555Purity>=98%
    Molecular Weight442.7 Type of CompoundTriterpenoids
    FormulaC30H50O2Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Cycloart-22-ene-3,25-diol

    Cycloart-22-ene-3,25-diol
    Product Name Cycloart-22-ene-3,25-diol
    CAS No.: 97456-49-0
    Catalog No.: CFN97555
    Molecular Formula: C30H50O2
    Molecular Weight: 442.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: Tyrosinase
    Source: The roots of Astragalus membranaceus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Biol Pharm Bull.2017, 40(6):797-806
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Inhibitors Compound Library
  • Triterpenoids Compound Library
  • Tyrosinase Inhibitor Library
  • Biological Activity
    Description: Cycloart-22-ene-3,25-diol shows tyrosinase inhibitory activity, the IC50 value of 77.5 uM .
    Targets: Tyrosinase
    In vitro:
    Chemistry of Natural Compounds, 2014 , 50 (5) :810-3.
    Tyrosinase Inhibitory Activity of Chemical Constituents of Euphorbia macrostegia[Reference: WebLink]

    METHODS AND RESULTS:
    The chloroform extract of the aerial parts of E. macrostegia has yielded a new compound, 2-(4-hydroxyphenyl)-ethylhentriacontanoate (1), along with hentriacontan-1-ol (2), lupenone (3), Cycloart-22-ene-3,25-diol (4), 3,3′,4′-tri-O-methylellagic acid (5), cleomiscosin (6), and glucoclioniasterol (stigmast-5-en-3-O-β-glucopyranoside) (7), and from the ethyl acetate extract of aerial parts of the plant isoquercetin (8), quercetin-3-O-α-arabinofuranoside (avicularin) (9), and rutin (10) have been isolated.
    CONCLUSIONS:
    Compounds 1–10 were tested for their tyrosinase inhibitory activity, and 2 exhibited an IC50 value of 71.4 μM, almost comparable to standard kojic acid (IC50 58.2 μM). Compounds 1–4 also showed good activity with IC50 values of 77.2, 78.6, 71.4, and 77.5 μM, respectively.
    Cycloart-22-ene-3,25-diol Description
    Source: The roots of Astragalus membranaceus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2589 mL 11.2943 mL 22.5887 mL 45.1773 mL 56.4717 mL
    5 mM 0.4518 mL 2.2589 mL 4.5177 mL 9.0355 mL 11.2943 mL
    10 mM 0.2259 mL 1.1294 mL 2.2589 mL 4.5177 mL 5.6472 mL
    50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
    100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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