ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Orders via your E-mail:
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Agric Food Chem....2021...Cells.2021, 10(11):2919. Preprints2022, 2022030063.Psychopharmacology (Berl).2020, 10.1007Universidade Estadual Paulista...2017...BMC Complement Altern Med.2014, 14:352Pharmaceutics2022, 14(2),376.Int. J. Mol. Sci.2022, 23(8), 4130.
Plant Physiol Biochem.2019, 144:355-364Evid Based Complement Alternat Me...2020...Phytomedicine.2021, 93:153789. Food Funct.2021, 12(13):5892-5902.J Food Biochem.2021, 45(7):e13774. J Ethnopharmacol.2022, 291:115159. Reprod Toxicol.2020, 96:1-10. J Nat Med.2021, doi: 10.1007.
J Food Biochem.2019, 43(9):e12970PLoS One.2015, 10(5):e0127060Asian J Beauty Cosmetol...2016...J Pharmaceutical and Biomedical A...2022...Oxid Med Cell Longev....2021...Integr Med Res.2021, 10(3):100723. J Pharm Biomed Anal.2017, 140:274-280
Our products had been exported to the following research institutions and universities, And still growing.
Medizinische Universit?t Wien (Austria)University of Zurich (Switzerland)Institute of Pathophysiology Me... (Austria)Warszawski Uniwersytet Medyczny (Poland)
University of Padjajaran (Indonesia)University of Otago (New Zealand)Universiti Malaysia Pahang (Malaysia)Washington State University (USA)
University of Oslo (Norway)Medical University of South Car... (USA)Universite de Lille1 (France)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Journal of Life Science2017, 233-240Anal Chim Acta.2018, 1039:162-171LWT2021, 147:111620.J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123Evid Based Complement Alternat Med.2020, 2020:2584783.Food Chem.2019, 279:80-87Agronomy2020, 10(3),388.Int. J. of Pha. and Phy. Res.2015, 7(1):144-149Sci Rep.2021, 11(1):11936.ACS Synth Biol.2022, doi: 10.1021.
Related Screening Libraries
||Dehydrocrenatidine is a JAK-specific inhibitor, can inhibit JAK-STAT3-dependent DU145 and MDA-MB-468 cell survival and induce cell apoptosis.
||JAK | STAT | IL Receptor|
|Mol Pharmacol. 2015 Apr;87(4):572-81. |
|Dehydrocrenatidine is a novel janus kinase inhibitor.[Pubmed: 25583084]|
|Janus kinase (JAK) 2 plays a pivotal role in the tumorigenesis of signal transducers and activators of transcription (STAT) 3 constitutively activated solid tumors. JAK2 mutations are involved in the pathogenesis of various types of hematopoietic disorders, such as myeloproliferative disorders, polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Thus, small-molecular inhibitors targeting JAK2 are potent for therapy of these diseases. |
METHODS AND RESULTS:
In this study, we screened 1,062,608 drug-like molecules from the ZINC database and 2080 natural product chemicals. We identified a novel JAK family kinase inhibitor, Dehydrocrenatidine, that inhibits JAK-STAT3-dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine represses constitutively activated JAK2 and STAT3, as well as interleukin-6-, interferon-α-, and interferon-γ-stimulated JAK activity, and STAT phosphorylation, and suppresses STAT3 and STAT1 downstream gene expression. Dehydrocrenatidine inhibits JAKs-JH1 domain overexpression-induced STAT3 and STAT1 phosphorylation. In addition, Dehydrocrenatidine inhibits JAK2-JH1 kinase activity in vitro. Importantly, Dehydrocrenatidine does not show significant effect on Src overexpression and epidermal growth factor-induced STAT3 activation.
Our results indicate that Dehydrocrenatidine is a JAK-specific inhibitor.
||The barks of Picrasma quassioides
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.