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    Natural Products
    Dehydrocrenatidine
    Dehydrocrenatidine
    Information
    CAS No. 65236-62-6 Price
    Catalog No.CFN97116Purity>=98%
    Molecular Weight254.3 Type of CompoundAlkaloids
    FormulaC15H14N2O2Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Dehydrocrenatidine

    Dehydrocrenatidine
    Product Name Dehydrocrenatidine
    CAS No.: 65236-62-6
    Catalog No.: CFN97116
    Molecular Formula: C15H14N2O2
    Molecular Weight: 254.3 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Yellow powder
    Targets: JAK | STAT | IL Receptor
    Source: The barks of Picrasma quassioides
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Journal of Life Science2017, 233-240
  • Anal Chim Acta.2018, 1039:162-171
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Inhibitors Compound Library
  • Alkaloids Compound Library
  • STAT Inhibitor Library
  • JAK Inhibitor Library
  • IL Receptor Inhibitor Library
  • Biological Activity
    Description: Dehydrocrenatidine is a JAK-specific inhibitor, can inhibit JAK-STAT3-dependent DU145 and MDA-MB-468 cell survival and induce cell apoptosis.
    Targets: JAK | STAT | IL Receptor
    In vitro:
    Mol Pharmacol. 2015 Apr;87(4):572-81.
    Dehydrocrenatidine is a novel janus kinase inhibitor.[Pubmed: 25583084]
    Janus kinase (JAK) 2 plays a pivotal role in the tumorigenesis of signal transducers and activators of transcription (STAT) 3 constitutively activated solid tumors. JAK2 mutations are involved in the pathogenesis of various types of hematopoietic disorders, such as myeloproliferative disorders, polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Thus, small-molecular inhibitors targeting JAK2 are potent for therapy of these diseases.
    METHODS AND RESULTS:
    In this study, we screened 1,062,608 drug-like molecules from the ZINC database and 2080 natural product chemicals. We identified a novel JAK family kinase inhibitor, Dehydrocrenatidine, that inhibits JAK-STAT3-dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine represses constitutively activated JAK2 and STAT3, as well as interleukin-6-, interferon-α-, and interferon-γ-stimulated JAK activity, and STAT phosphorylation, and suppresses STAT3 and STAT1 downstream gene expression. Dehydrocrenatidine inhibits JAKs-JH1 domain overexpression-induced STAT3 and STAT1 phosphorylation. In addition, Dehydrocrenatidine inhibits JAK2-JH1 kinase activity in vitro. Importantly, Dehydrocrenatidine does not show significant effect on Src overexpression and epidermal growth factor-induced STAT3 activation.
    CONCLUSIONS:
    Our results indicate that Dehydrocrenatidine is a JAK-specific inhibitor.
    Dehydrocrenatidine Description
    Source: The barks of Picrasma quassioides
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9324 mL 19.6618 mL 39.3236 mL 78.6473 mL 98.3091 mL
    5 mM 0.7865 mL 3.9324 mL 7.8647 mL 15.7295 mL 19.6618 mL
    10 mM 0.3932 mL 1.9662 mL 3.9324 mL 7.8647 mL 9.8309 mL
    50 mM 0.0786 mL 0.3932 mL 0.7865 mL 1.5729 mL 1.9662 mL
    100 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.7865 mL 0.9831 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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