ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Chem Biol Interact.2018, 283:59-74The Japan Society for Analy. Chem...2017...Food Chem.2016, 191:81-90Sci Rep.2021, 11(1):11936.Int J Mol Sci.2022, 23(23):14545.J Microbiol Immunol Infect....2021...Agronomy2020, 10(10),1489BMC Complement Altern Med....2018...
Am J Chin Med.2015, 30:1-22Nutrients.2020, 12(5):1242.Int J Mol Sci.2015, 16(8):18396-411Int J Pharm.2022, 618:121636. J Nat Med.2020, 74(3):550-560.Antioxidants (Basel).2021, 10(10):1620.Oncol Lett.2020, 20(4):122.Appl. Sci.2020, 10(8),2804
Int J Mol Sci.2022, 23(23):15213.Applied Physics B2021, 127(92).Free Radic Biol Med.2016, 97:307-319Phytomedicine.2022, 99:154025.J Food Compos Anal2017, 62:197-204J Ethnopharmacol.2019, 236:31-41Acta Pharmaceutica Hungarica...2016...
Our products had been exported to the following research institutions and universities, And still growing.
Kamphaengphet Rajabhat University (Thailand)Max-Planck-Insitut (Germany)Cancer Research Initatives Foun... (Malaysia)Martin Luther University of Hal... (Germany)
Seoul National University of Sc... (Korea)Universidade do Porto (Portugal)Shanghai Institute of Biochemis... (China)Complutense University of Madrid (Spain)
Chinese University of Hong Kong (China)Mahidol University (Thailand)Vin?a Institute of Nuclear Scie... (Serbia)
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Chemistry of Plant Materials.2019, 129-136Anat Rec2018, 24264Front Pharmacol.2020, 11:251.J Anal Methods Chem.2022, 2022:2229500.J of Advanced Scientific R.2020, 11(3), p109-120.Korean Journal of Pharmacognosy2017, 48(4):320-328Cell Biochem Funct.2018, 36(6):303-311Int J Mol Sci.2021, 22(19):10405.Molecules.2019, 24(6):E1177Biomed Pharmacother.2019, 111:262-269
Related Screening Libraries
|| Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of inflammatory disease.|
||NO | COX | NOS | MAPK|
|Int Immunopharmacol. 2012 Dec;14(4):734-9. |
|Anti-inflammatory effects of dehydrogeijerin in LPS-stimulated murine macrophages.[Pubmed: 23102664]|
METHODS AND RESULTS:
In this study, we investigated whether Heracleum (H) moellendorffii Hance-derived Dehydrogeijerin and geijerin could be used to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophage cell lines, Raw 264.7 cells. Dehydrogeijerin reduced nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production from LPS-stimulated Raw 264.7 cells, but on the other hand, geijerin did not reduce NO production. Dehydrogeijerin, unlike geijerin, has a double bond at C2'-C3' with an oxo function at C1'. Pre-treatment of Raw 264.7 cells with Dehydrogeijerin reduced the production of cyclooxigenase-2 (COX-2) and pro-inflammatory cytokines. These inhibitory effects were associated with decreases in the phosphorylation of mitogen-activated protein (MAP) kinases.
Our results indicate that Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that Dehydrogeijerin could be a potential candidate for the treatment of inflammatory disease.
||The roots of Angelica dahurica var. formosana cv. Chuanbaizhi.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Zhongguo Zhong Yao Za Zhi. 2015 Jun;40(11):2148-56. |
|Chemical constituents from lipophilic parts in roots of Angelica dahurica var. formosana cv. Chuanbaizhi.[Pubmed: 26552172]|
|The chemical constituents from lipophilic parts in the roots of Angelica dahurica var. formosana cv. Chuanbaizhi were studied in this paper. |
METHODS AND RESULTS:
The compounds were separated and purified by repeated column chromatographic methods on silica gel and HPLC, and the chemical structures of compounds were determined by spectral data analyses. Twenty-nine compounds were obtained and identified as isoimperatorin (1), β-sitosterol (2), imperatorin (3), bergapten (4), osthenol (5), xanthotoxin (6), isoimpinellin (7), Dehydrogeijerin (8), phellopterin (9), isodemethylfuropinarine (10), 7-demethylsuberosin (11), alloimperatorin (12), xanthotoxol (13), isooxypeucedanin (14), alloisoimperatorin (15), demethylfuropinarine (16), 5-hydroxy-8-methoxypsoralen (17), oxypeucedanin methanolate (18), pabulenol (19), byakangelicin (20), marmesin (21), (+) -decursinol (22), heraclenol (23), oxypeucedanin hydrate (24), marmesinin (25), ulopterol (26), erythro-guaiacylglycerol-β-ferulic acid ether (27), threo-guaiacylglycerol-β-ferulic acid ether (28), and uracil (29).
Compounds 5, 8, 11, 18, 21-23, and 26-28 were obtained from the roots of title plant for the first time.