ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $114.9 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
New Zealand J. Forestry Sci.2014, 44:17Industrial Food Engineering...2015...Jour. of Stored Pro & Postharvest...2016...Evid Based Complement Alternat Me...2017...Industrial Crops and Products...2017...Int J Mol Sci.2018, 19(9):E2601Evid Based Complement Alternat Me...2018...Sci Adv.2018, 4(10)
Oncology Letters2018, 4690-4696Biochem Biophys Res Commun....2018...Planta Med.2018, 84(15):1101-1109ACS Chem Biol.2019, 14(5):873-881BMC Complement Altern Med....2019...Molecules.2019, 24(6):E1177Pharmaceutical Chemistry Journal...2019...Int Immunopharmacol.2019, 71:22-31
Br J Pharmacol.2020, 10.1111Nutrients.2020, 12(12):3607. Pharmacol Res.2020, 161:105205.Int J Biol Macromol.2020, 169:342-351Antioxidants (Basel).2020, 9(11):1121.Antioxidants (Basel).2020, 9(6):544. Inflammation.2021, doi: 10.1007
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Our products had been exported to the following research institutions and universities, And still growing.
National Cancer Center Research... (Japan)Universidad de Buenos Aires (Argentina)Melbourne University (Australia)University of South Australia (Australia)
University of Hertfordshire (United Kingdom)University of Vienna (Austria)Shanghai Institute of Biochemis... (China)Seoul National University (Korea)
University of the Basque Country (Spain)University of Eastern Finland (Finland)University of Wollongong (Australia)
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Demethylwedelolactone
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Int J Mol Sci.2017, 19(1)Korean J of Crop Science2019, 452-458Chemistry of Natural Compounds2020, 56,423-426Toxicol In Vitro.2018, 52:94-105Molecules.2019, 24(4):E709Plos One.2020, 10.1371Eur J Pharmacol.2020, 889:173589.Arch Pharm Res.2015, 38(6):1080-9Food Res Int.2020, 133:109130.J Herbmed Pharmacol.2018, 7(4):280-286
Related Screening Libraries
| Description: |
Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells. |
| Targets: |
NF-kB | IkB | MEK | ERK | MMP(e.g.TIMP) | IKK |
| In vitro: |
| Phytother Res. 2003 Apr;17(4):420-1. | | Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.[Pubmed: 12722155] | Wedelolactone (WL) and Demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro).
METHODS AND RESULTS:
Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively. | | Eur J Med Chem. 2012 Oct;56:361-7. | | Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.[Pubmed: 22926226] | The anticancer properties of Demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and Demethylwedelolactone on human MDA-MB-231 breast cancer cells.
METHODS AND RESULTS:
We found that WEL and Demethylwedelolactone inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells. In addition, WEL and Demethylwedelolactone reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, Demethylwedelolactone suppressed the metastasis and lung colonization of the tumor cells in the nude mice.
CONCLUSIONS:
Altogether, these data suggest that Demethylwedelolactone derivatives exert anti-invasive growth effect on breast cancer cells. |
|
Demethylwedelolactone Description
| Source: |
The herbs of Eclipta prostrata |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.331 mL |
16.655 mL |
33.31 mL |
66.62 mL |
83.275 mL |
| 5 mM |
0.6662 mL |
3.331 mL |
6.662 mL |
13.324 mL |
16.655 mL |
| 10 mM |
0.3331 mL |
1.6655 mL |
3.331 mL |
6.662 mL |
8.3275 mL |
| 50 mM |
0.0666 mL |
0.3331 mL |
0.6662 mL |
1.3324 mL |
1.6655 mL |
| 100 mM |
0.0333 mL |
0.1666 mL |
0.3331 mL |
0.6662 mL |
0.8328 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
