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| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Front Pharmacol.2021, 12:762829. Journal of Life Science2017, 233-240J of Physics Conference Series...2019...J. of The Korean Society of Food ...2017...Int J Mol Med.2020, 45(5):1514-1524.Molecules.2017, 22(2)J Chromatogr Sci.2015, 53(5):824-9J Biotechnol.2020, 318:10-19.
Molecules.2021, 26(16):4722.Fitoterapia.2018, 124:92-102Curr Top Med Chem....2020...Toxins (Basel).2019, 11(10):E575TCI CO.2019, US20190151281A1Industrial Crops and Products...2018...Sci Rep. 2018, 10590Front Cell Dev Biol.2021, 9:638174.
TCI CO.2019, US20190151257A1Phytochemistry Letters2017, 449-455South African Journal of Botany...2021...Int Immunopharmacol.2022, 106:108603.Appl. Sci. 2021, 11(23),11099.J of Applied Pharmaceutical Scien...2020...Journal of Molecular Liquids...2021...
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Our products had been exported to the following research institutions and universities, And still growing.
Griffith University (Australia)Medical University of Gdansk (Poland)University of Zurich (Switzerland)Univerzita Karlova v Praze (Czech Republic)
Technical University of Denmark (Denmark)University of East Anglia (United Kingdom)Nanjing University of Chinese M... (China)University of Queensland (Australia)
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Dihydrodehydrodiconiferyl alcohol
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Pharmaceutics.2021, 13(2):187. Chem Biol Interact.2016, 258:59-68Toxicol In Vitro.2019, 59:161-178Cell Metab.2020, S1550-4131(20)30002-4PLoS One.2015, 10(5):e0127060Mol Cells.2018, 41(8):771-780Medicina (Kaunas).2020, 56(12):685.Evid Based Complement Alternat Med.2017, 2017:9764843Molecules.2020, 25(11):2599. Front Aging Neurosci.2018, 10:269
Related Screening Libraries
| Description: |
Dihydrodehydrodiconiferyl alcohol exhibits in vitro cytotoxicity in various cancer cell lines. It may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis. |
| Targets: |
TNF-α |
| In vitro: |
| Biol Pharm Bull. 2015;38(2):228-34. | | Antifibrotic compounds from Liriodendron tulipifera attenuating HSC-T6 proliferation and TNF-α production in RAW264.7 cells.[Pubmed: 25747981] | The inhibition of hepatic stellate cell (HSC) proliferation has been considered as an effective therapeutic target for the treatment of liver fibrosis.
METHODS AND RESULTS:
The methanolic extract of Liriodendron tulipifera showed significant inhibitory activity against the proliferation of HSCs. Bioactivity-guided isolation afforded twelve compounds including (-)-sesamin (1), (-)-syringaresinol (2), (+)-Dihydrodehydrodiconiferyl alcohol (3), salvinal (4), (+)-guaiacylglycerol-8-O-4'-dihydroconiferyl ether (5), (±)-guaiacylglycerol-8-O-4'-sinapyl alcohol ether (6), tanegool (7), (+)-5,5'-dimethoxy-7-oxolariciresinol (8), 3-hydroxy-4-methoxyacetophenone (9), 4-acetoxymethylphenol (10), (-)-paramicholide (11), and blumenol A (12). Among the compounds isolated, 2, 3 and 4 significantly attenuated the proliferation of the activated HSC-T6 cells. The maximal dose of these compounds, however, showed no cytotoxicity in primary cultured rat hepatocytes. Collagen deposition in the activated HSC-T6 cells was reduced by 2, 3 and 4. Also, the increased production of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α induced by lipopolysaccharide was decreased by 3 and 4 in RAW264.7 macrophage cells. Collectively, (-)-syringaresinol (2), (+)-Dihydrodehydrodiconiferyl alcohol (3), and salvinal (4) isolated from L. tulipifera leaves and twigs exhibited selective antifibrotic activities toward the activated HSCs and suppressed TNF-α production in RAW264.7 macrophages.
CONCLUSIONS:
These compounds may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis. |
|
Dihydrodehydrodiconiferyl alcohol Description
| Source: |
The barks of Eucommia ulmoides Oliver |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.7747 mL |
13.8735 mL |
27.7469 mL |
55.4939 mL |
69.3674 mL |
| 5 mM |
0.5549 mL |
2.7747 mL |
5.5494 mL |
11.0988 mL |
13.8735 mL |
| 10 mM |
0.2775 mL |
1.3873 mL |
2.7747 mL |
5.5494 mL |
6.9367 mL |
| 50 mM |
0.0555 mL |
0.2775 mL |
0.5549 mL |
1.1099 mL |
1.3873 mL |
| 100 mM |
0.0277 mL |
0.1387 mL |
0.2775 mL |
0.5549 mL |
0.6937 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| at. Prod. Lett., 1994, 4(4):267-72. | | Revision of the NMR Assignments of Pterostilbene and of Dihydrodehydrodiconieferyl alcohol: Cytotoxic Constituents from Anogeissus acuminata.[Reference: WebLink] | Further phytochemical work on Anogeissus acuminata var. lanceolata (Combretaceae) led to the isolation of pterostilbene (1), Dihydrodehydrodiconiferyl alcohol (2), and conocarpan (3).
METHODS AND RESULTS:
The structure of these compounds were determined by spectroscopic means, mainly through 1D and 2D NMR experiments. A revision of some of the 13C NMR chemical shifts of 1 and 2 were made possible by HETCOR, FLOCK, and selective INEPT experiments. Homonuclear spin-decoupling and 1H-1H COSY experiments also enabled the precise assignment of the 1H NMR chemical shifts of 2.
CONCLUSIONS:
Compounds 1–3 exhibited in vitro cytotoxicity in various cancer cell lines. This is the first isolation of 1–3 from Anogeissus. |
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