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1. Reference standards
2. Pharmacological research
3. Inhibitors
Dihydroquinine
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $10.8 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
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Dihydroquinine
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manager@chemfaces.com
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Chem. of Vegetable Raw Materials2020, 97-105Asian Pac J Tropical Bio.2020, 10(6):239-247Acta Physiologiae Plantarum2015, 37:1736Korean J Acupunct2020, 37:104-121Foods.2021, 10(11):2754.J Biochem Mol Toxicol.2020, 34(7):e22489.J Food Biochem.2019, 43(9):e12970Molecules.2018, 23(2)Pharmacol Res.2022, 182:106346.J Am Soc Mass Spectrom.2021, 32(9):2451-2462.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Dihydroquinine has equivalent antimalarial activity. |
| In vitro: |
| Transactions of the Royal Society of Tropical Medicine & Hygiene, 1996,164(2):380-6. | | Antimalarial activity and interactions between quinine, dihydroquinine and 3-hydroxyquinine against Plasmodium falciparum in vitro.[Reference: WebLink] |
METHODS AND RESULTS:
The antimalarial activities of quinine, Dihydroquinine (a natural impurity found in commercial pharmaceutical formulations of quinine) and 3-hydroxyquinine (the principal metabolite of quinine in humans) were tested both individually and in pairs against 5 strains of Plasmodium falciparum isolated from patients in Thailand. The median inhibitory concentrations (IC50) were similar for quinine (168 nmol/L, range 68–366), and Dihydroquinine (129 nmol/L, range 54–324), and both were significantly lower than that of 3-hydroxyquinine (1160 nmol/L, range 378–3154) (P = 0·027). When these drugs were tested in combination, there was no evidence of synergy or antagonism, as determined by fractionary inhibitory indices and isobolograms.
CONCLUSIONS:
Quinine and its impurity, Dihydroquinine, have equivalent antimalarial activities which are approximately 10 times greater than that of the metabolite 3-hydroxyquinine. These 2 compounds, which are not usually measured in specific drug assays, contribute to antimalarial activity after quinine administration. |
|
Dihydroquinine Description
| Source: |
|
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.0637 mL |
15.3186 mL |
30.6373 mL |
61.2745 mL |
76.5931 mL |
| 5 mM |
0.6127 mL |
3.0637 mL |
6.1275 mL |
12.2549 mL |
15.3186 mL |
| 10 mM |
0.3064 mL |
1.5319 mL |
3.0637 mL |
6.1275 mL |
7.6593 mL |
| 50 mM |
0.0613 mL |
0.3064 mL |
0.6127 mL |
1.2255 mL |
1.5319 mL |
| 100 mM |
0.0306 mL |
0.1532 mL |
0.3064 mL |
0.6127 mL |
0.7659 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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