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    Natural Products
    Dimethylmatairesinol
    Information
    CAS No. 943989-68-2 Price
    Catalog No.CFN97524Purity>=98%
    Molecular Weight392.4 Type of CompoundXanthones
    FormulaC19H20O9Physical DescriptionYellow powder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Dimethylmatairesinol

    Dimethylmatairesinol
    Product Name Dimethylmatairesinol
    CAS No.: 943989-68-2
    Catalog No.: CFN97524
    Molecular Formula: C19H20O9
    Molecular Weight: 392.4 g/mol
    Purity: >=98%
    Type of Compound: Xanthones
    Physical Desc.: Yellow powder
    Source: The herbs of Macaranga tanarius
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Evid Based Complement Alternat Med.2018, 2018:8565132
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cytotoxic Compound Library
  • Anti-allergy Compound Library
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  • Biological Activity
    Description: Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung carcinoma, MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma ).
    In vitro:
    Planta Med. 2003 Aug;69(8):733-8.
    A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.[Pubmed: 14531024]

    METHODS AND RESULTS:
    In the roots of Anthriscus sylvestris 12 different lignans were detected. Arctigenin, Dimethylmatairesinol, dimethylthujaplicatin, podophyllotoxin, 7-hydroxyyatein and 7-hydroxyanhydropodorhizol have not been previously reported to be present in A. sylvestris. In the cell suspension cultures, which were initiated for this study, trace amounts of deoxypodophyllotoxin could be detected. With these cell suspension cultures we carried out feeding experiments using deoxypodophyllotoxin, yatein and, anhydropodorhizol.
    CONCLUSIONS:
    Yatein had a toxic effect on the cell cultures and was, like anhydropodorhizol, not converted into any detectable product. Deoxypodophyllotoxin, in contrast, was converted into podophyllotoxin, yielding significantly higher concentration than measured in whole plants.
    Journal of Health Science, 2011, 57 (57) :184-7.
    Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora[Reference: WebLink]
    Immunoglobulin E (IgE) plays an important role in allergic diseases.
    METHODS AND RESULTS:
    In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as Dimethylmatairesinol. Authentic Dimethylmatairesinol exhibited similar ac-tivity.
    CONCLUSIONS:
    Thus, the extract of C. camphora and its com-ponents including Dimethylmatairesinol have poten-tial as an anti-allergic agent.
    Dimethylmatairesinol Description
    Source: The herbs of Macaranga tanarius
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5484 mL 12.7421 mL 25.4842 mL 50.9684 mL 63.7105 mL
    5 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
    10 mM 0.2548 mL 1.2742 mL 2.5484 mL 5.0968 mL 6.371 mL
    50 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
    100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5097 mL 0.6371 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Cell Research:
    Phytochemistry , 2000 , 55 (3) :227-32.
    Cytotoxicity of extractives from Taiwania cryptomerioides heartwood.[Reference: WebLink]
    The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated.
    METHODS AND RESULTS:
    Three human tumor cells including A-549 lung carcinoma. MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure-cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and Dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells.
    CONCLUSIONS:
    Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the tumor cell death induced by taiwanin A was due to apoptosis.
    Structure Identification:
    Spectrochim Acta A Mol Biomol Spectrosc. 2006 Jan;63(1):234-9.
    Detailed 1H and 13C NMR structural assignment of three biologically active lignan lactones.[Pubmed: 16344252]

    METHODS AND RESULTS:
    In this paper we present a complete 1H and 13C NMR spectral analysis of three lignan lactones (methylpluviatolide, Dimethylmatairesinol and hinokinin) by the use of techniques such as COSY, HMQC, HMBC and J-resolved. Complete assignment and all homonuclear hydrogen coupling constant measurements were performed, providing enough data also to the confirmation of the relative stereochemistry.
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