ChemFaces is a professional high-purity natural products manufacturer.
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3. Inhibitors
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
J. of Agricultural Science...2015...Phytochemistry.2017, 141:162-170Preprints2017, 2017120176Journal of Life Science2017, 233-240JPC-Journal of Planar Chromatogra...2017...Sci Rep. 2017, 8207(7)Appl Microbiol Biotechnol....2018...Biol Pharm Bull.2018, 41(1):65-72
Sci Rep.2018, 8(1)Saf Health Work.2019, 10(2):196-204Front Neurosci.2019, 13:1091Neuropharmacology2019, 151437J Adv Res.2019, 17:85-94Evid Based Complement Alternat Me...2019...Food Chem.2019, 279:80-87LWT2020, 130:109535
Food Res Int.2020, 133:109130.UDC.2020, 19(4).Asian Pac J Cancer Prev. ...2020...Molecules.2020, 25(11):2599. Food Addit Contam Part A Chem Ana...2020...Int Immunopharmacol. 2020, 83:106403.Natural Product Communications...2020...
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Our products had been exported to the following research institutions and universities, And still growing.
University of Indonesia (Indonesia)Universidade Federal de Pernamb... (Brazil)Celltrion Chemical Research Ins... (Korea)Kamphaengphet Rajabhat University (Thailand)
Aveiro University (Portugal)University of Liège (Belgium)Anna University (India)Uniwersytet Gdański (Poland)
National Cancer Institute (USA)Hamdard University (India)University of Queensland (Australia)
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Dimethylmatairesinol
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Evid Based Complement Alternat Med.2018, 2018:8565132Biochemical Systematics and Ecology2018, 81PLoS One.2020, 15(2):e0220084.J Ethnopharmacol.2021, 267:113615.Oncotarget.2017, 8(64):108006-108019J Nat Sc Biol Med2019, 10(2):149-156Evid Based Complement Alternat Med.2015, 2015:165457Phytomedicine.2019, 56:48-56Biochem Biophys Res Commun.2017, 494(3-4):587-593Biology (Basel).2020, 9(11):363.
Related Screening Libraries
| Description: |
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung carcinoma, MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma ). |
| In vitro: |
| Planta Med. 2003 Aug;69(8):733-8. | | A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.[Pubmed: 14531024] |
METHODS AND RESULTS:
In the roots of Anthriscus sylvestris 12 different lignans were detected. Arctigenin, Dimethylmatairesinol, dimethylthujaplicatin, podophyllotoxin, 7-hydroxyyatein and 7-hydroxyanhydropodorhizol have not been previously reported to be present in A. sylvestris. In the cell suspension cultures, which were initiated for this study, trace amounts of deoxypodophyllotoxin could be detected. With these cell suspension cultures we carried out feeding experiments using deoxypodophyllotoxin, yatein and, anhydropodorhizol.
CONCLUSIONS:
Yatein had a toxic effect on the cell cultures and was, like anhydropodorhizol, not converted into any detectable product. Deoxypodophyllotoxin, in contrast, was converted into podophyllotoxin, yielding significantly higher concentration than measured in whole plants. | | Journal of Health Science, 2011, 57 (57) :184-7. | | Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora[Reference: WebLink] | Immunoglobulin E (IgE) plays an important role in allergic diseases.
METHODS AND RESULTS:
In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as Dimethylmatairesinol. Authentic Dimethylmatairesinol exhibited similar ac-tivity.
CONCLUSIONS:
Thus, the extract of C. camphora and its com-ponents including Dimethylmatairesinol have poten-tial as an anti-allergic agent. |
|
Dimethylmatairesinol Description
| Source: |
The herbs of Macaranga tanarius |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.5484 mL |
12.7421 mL |
25.4842 mL |
50.9684 mL |
63.7105 mL |
| 5 mM |
0.5097 mL |
2.5484 mL |
5.0968 mL |
10.1937 mL |
12.7421 mL |
| 10 mM |
0.2548 mL |
1.2742 mL |
2.5484 mL |
5.0968 mL |
6.371 mL |
| 50 mM |
0.051 mL |
0.2548 mL |
0.5097 mL |
1.0194 mL |
1.2742 mL |
| 100 mM |
0.0255 mL |
0.1274 mL |
0.2548 mL |
0.5097 mL |
0.6371 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Cell Research: |
| Phytochemistry , 2000 , 55 (3) :227-32. | | Cytotoxicity of extractives from Taiwania cryptomerioides heartwood.[Reference: WebLink] | The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated.
METHODS AND RESULTS:
Three human tumor cells including A-549 lung carcinoma. MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure-cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and Dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells.
CONCLUSIONS:
Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the tumor cell death induced by taiwanin A was due to apoptosis. |
|
| Structure Identification: |
| Spectrochim Acta A Mol Biomol Spectrosc. 2006 Jan;63(1):234-9. | | Detailed 1H and 13C NMR structural assignment of three biologically active lignan lactones.[Pubmed: 16344252] |
METHODS AND RESULTS:
In this paper we present a complete 1H and 13C NMR spectral analysis of three lignan lactones (methylpluviatolide, Dimethylmatairesinol and hinokinin) by the use of techniques such as COSY, HMQC, HMBC and J-resolved. Complete assignment and all homonuclear hydrogen coupling constant measurements were performed, providing enough data also to the confirmation of the relative stereochemistry. |
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