ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Food Res Int.2022, 157:111207.Molecules.2020, 25(21):5091.Phytother Res.2018, 32(5):923-932Front Nutr.2021, 8: 687851.Sci Rep.2021, 11(1):14180. Phytochemistry Letters2015, 243-247Front Plant Sci.2017, 8:723Int. J. Mol. Sci.2022, 23(14),7699;
Phytomedicine.2021, 84:153501. Front Plant Sci.2020, 11:630.Int J Biol Macromol.2018, 112:1093-1103J Ethnopharmacol.2017, 197:157-164Journal of Apicultural Research...2021...Chem Biol Interact.2019, 315:108910Food Control2022, 132:108434.Process Biochemistry2019, 87:213-220
Toxins (Basel).2021, 13(12):898.Neuropharmacology2019, 151437J of Health Science and Alternati...2019...J. Traditional Thai Medical Res. ...2022...Phytother Res.2020, 34(4):788-795.Mol Med Rep.2015, 12(5):7789-95The Malaysian journal of patholog...2019...
Our products had been exported to the following research institutions and universities, And still growing.
Medizinische Universit?t Wien (Austria)University of Amsterdam (Netherlands)Korea Institute of Oriental Med... (Korea)Charles Sturt University (Denmark)
The Vancouver Prostate Centre (... (Canada)Celltrion Chemical Research Ins... (Korea)Yale University (USA)Auburn University (USA)
National Cancer Center Research... (Japan)Utah State University (USA)University of South Australia (Australia)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Am J Chin Med.2015, 30:1-22Eur J Pharmacol.2021, 906:174220.Pharmacogn Mag.2015, 11(43):562-6J of Dentistry & Oral Health2019, 2641-1962Microorganisms.2021, 9(12):2514.Front Pharmacol.2021, 12:690113.bioRxiv2021, 462065.Biomolecules.2020, 10(2):E184Molecules.2019, 24(6):E1155Phytomedicine.2019, 67:153159
Related Screening Libraries
|| Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A549 cells via an inhibition of DNA repair synthesis.|
|Bioorg Med Chem. 2008 Apr 15;16(8):4331-40. |
|Inhibitors of DNA polymerase beta: activity and mechanism.[Pubmed: 18343122 ]|
METHODS AND RESULTS:
Bioassay-guided fractionation of extracts prepared from Couepia polyandra and Edgeworthia gardneri resulted in the isolation of the DNA polymerase beta (pol beta) inhibitors oleanolic acid (1), Edgeworin (2), betulinic acid (3), and stigmasterol (4). Study of these pol beta inhibitors revealed that three of them inhibited both the lyase and polymerase activities of DNA polymerase beta, while stigmasterol inhibited only the lyase activity. Further investigation indicated that the four inhibitors had substantially different effects on the DNA-pol beta binary complex that is believed to be an obligatory intermediate in the lyase reaction. It was found that the inhibitors potentiated the inhibitory action of the anticancer drug bleomycin in cultured A549 cells, without any influence on the expression of pol beta in the cells.
The results of the unscheduled DNA synthesis assay support the thesis that the potentiation of bleomycin cytotoxicity by DNA pol beta inhibitors was a result of an inhibition of DNA repair synthesis.
|Biol Pharm Bull. 2004 Aug;27(8):1312-6. |
|Antiproliferative constituents in plants 14. Coumarins and acridone alkaloids from Boenninghausenia japonica NAKAI.[Pubmed: 15305045]|
METHODS AND RESULTS:
The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth. Fractionation of the extracts has resulted in isolation of 1,3-dihydroxy-4-(2'-hydroxy-3'-hydroxymethyl-3',4'-epoxy-butyl)-N-methylacridone, 1,3-dihydroxy-4-[(Z)-3'-hydroxy-3'-methyl-buten-1'-yl]-N-methylacridone, 3-(1',1'-dimethylallyl)-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one, casegravol, cis-casegravol, and Edgeworin in addition to 9 compounds reported from B. japonica and B. albiflora.
The isolates from this plant and some related compounds were tested for antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
||The roots and stems of Edgeworthia chrysantha LINDL.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.