Esculentic acid | CAS:103974-74-9 | Manufacturer ChemFaces

Esculentic acid

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Description:

Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice.

Targets:

COX | TNF-α | IL Receptor

In vivo:

Int Immunopharmacol. 2014 Nov;23(1):229-35.

Protective effects of esculentic acid against endotoxic shock in Kunming mice.[Pubmed: 25242384]

Esculentic acid (EA), a triterpene compound extracted from the root of Phytolacca esculenta (the Chinese name Shang Lu), has been widely used to therapy a variety of inflammatory diseases such as rheumatoid arthritis, edema, hepatitis and bronchitis.
METHODS AND RESULTS:
The present study was designed to investigate the protective effects of EA against LPS-induced endotoxic shock by the intraperitoneal injection of EA (1, 5 and 10 mg/kg) prior to LPS stimulation (1 mg/kg, i.p.). We examined the effects of EA on the survival rate of mice, inflammatory cytokine and pro-inflammatory mediator production, histopathological changes and protein expression of COX-2 in tissue sections from lung, liver and kidney. The results indicate that EA not only increases the survival rate of mice, but decreases the levels of TNF-α, IL-6, NO and PGE2 in serum or tissues, histopathological changes and COX-2 protein expression also. Furthermore, EA also increases the levels of anti-inflammatory cytokine IL-10 in serum.
CONCLUSIONS:
Overall, these data suggest that the protective effects of EA against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice.

Esculentic acid Description

Source:	The roots of Phytolacca acinosa Roxb
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kinase Assay:

Eur J Pharmacol. 2014 Oct 5;740:532-8.

Esculentic acid, a novel and selective COX-2 inhibitor with anti-inflammatory effect in vivo and in vitro.[Pubmed: 24991788]

Esculentic acid (EA), a pentacyclic triterpenoids compound extracted from the Chinese herb Phytolacca esculenta, has long been used in traditional Chinese medicine for the treatment of rheumatoid arthritis, edema, hepatitis and bronchitis disease. The present study aimed to investigate the anti-inflammatory effect of EA in vivo and in vitro and the effect of EA on cyclooxygenase (COX) protein expression.
METHODS AND RESULTS:
To gain insight into the anti-inflammatory effect of EA both in vivo and in vitro and its effect on COX-2 expression, we used animal inflammatory models and lipopolysaccharide (LPS)-induced mouse peritoneal macrophages to examine the anti-inflammatory action of EA. Our findings demonstrated that EA possessed potent anti-inflammatory activity both in vivo and in vitro, while the anti-inflammation action in vitro may be attributed to the inhibition of the level of TNF-α and IL-6 pro-inflammatory cytokines and PGE2 inflammatory mediator in macrophages. Meanwhile, the production of PGE2 was possibly associated with COX-2 protein expression which was similar to that of NSAIDS.
CONCLUSIONS:
The study extends our understanding of the anti-inflammatory effect of EA both in vivo and in vitro and provides clarification of the molecular mechanisms underlying the effect of EA on PGE2 production, extending a novel aspect to the pharmacological activity of EA.

CAS No.	103974-74-9	Price
Catalog No.	CFN99059	Purity	>=98%
Molecular Weight	488.7	Type of Compound	Triterpenoids
Formula	C₃₀H₄₈O₅	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	Esculentic acid
CAS No.:	103974-74-9
Catalog No.:	CFN99059
Molecular Formula:	C₃₀H₄₈O₅
Molecular Weight:	488.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Targets:	COX \| TNF-伪 \| IL Receptor
Source:	The roots of Phytolacca acinosa Roxb
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Anti-endotoxic shock Compound Library Anti-hemolytic Compound Library Anti-rheumatism-arthritis Compound Library Anticomplementary Compound Library Triterpenoids Compound Library TNF-α Inhibitor Library IL Receptor Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0462 mL	10.2312 mL	20.4625 mL	40.9249 mL	51.1561 mL
5 mM	0.4092 mL	2.0462 mL	4.0925 mL	8.185 mL	10.2312 mL
10 mM	0.2046 mL	1.0231 mL	2.0462 mL	4.0925 mL	5.1156 mL
50 mM	0.0409 mL	0.2046 mL	0.4092 mL	0.8185 mL	1.0231 mL
100 mM	0.0205 mL	0.1023 mL	0.2046 mL	0.4092 mL	0.5116 mL

CFN99059	Esculentic acid	103974-74-9	488.7	C₃₀H₄₈O₅
CFN98444	Actinidic acid	341971-45-7	486.7	C₃₀H₄₆O₅
CFN98688	Asiatic acid	464-92-6	488.7	C₃₀H₄₈O₅
CFN96830	3-O-Coumaroylasiatic acid	143773-52-8	634.85	C₃₉H₅₄O₇
CFN99912	Asiaticoside	16830-15-2	959.12	C₄₈H₇₈O₁₉
CFN99913	Madecassoside	34540-22-2	975.13	C₄₈H₇₈O₂₀
CFN95124	Asiaticoside B	125265-68-1	975.13	C₄₈H₇₈O₂₀
CFN99914	Madecassic acid	18449-41-7	504.70	C₃₀H₄₈O₆
CFN99481	2,24-Dihydroxyursolic acid	143839-02-5	488.7	C₃₀H₄₈O₅
CFN96162	Barbinervic acid	64199-78-6	488.7	C₃₀H₄₈O₅