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Euchrestaflavanone B
Euchrestaflavanone B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Euchrestaflavanone B
Price:
CAS No.: 87402-91-3
Catalog No.: CFN96525
Molecular Formula: C25H28O6
Molecular Weight: 424.49 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The root barks of Cudrania tricuspidata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of protein kinase CKII activity.
Targets: PARP | Antifection
In vitro:
Oncol Res. 2005;15(6):327-32.
Inhibition of protein kinase CKII activity by euchrestaflavanone B purified from Cudrania tricuspidata.[Pubmed: 16408697]

METHODS AND RESULTS:
The CKII (EC 2.7.1.37) inhibitory compound was purified from the root barks of Cudrania tricuspidata and identified as (2S)-2-[2,4-dihydroxy-5-(3-methyl-but-2-enyl)-phenyl]-5,7-dihyroxy-6-(3-methyl-but-2-enyl)chroman-4-one (Euchrestaflavanone B). Euchrestaflavanone B was shown to inhibit the phosphotransferase activity of CKII with IC50 of about 78 microM. Steady-state studies revealed that Euchrestaflavanone B acted as a competitive inhibitor with respect to the substrate ATP. A value of 16.4 microM was obtained for the apparent Ki. Concentration of 0.8 microM Euchrestaflavanone B caused 50% growth inhibition of human cancer cells U937 and HeLa. Euchrestaflavanone B-induced cell death was characterized with the cleavage of poly(ADP-ribose) polymerase and procaspase-3, indicating that the inhibitor triggered apoptosis.
CONCLUSIONS:
Because protein kinase CKII is involved in cell proliferation and oncogenesis, these results suggest that Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of CKII activity.
Euchrestaflavanone B Description
Source: The root barks of Cudrania tricuspidata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3558 mL 11.7788 mL 23.5577 mL 47.1154 mL 58.8942 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL 9.4231 mL 11.7788 mL
10 mM 0.2356 mL 1.1779 mL 2.3558 mL 4.7115 mL 5.8894 mL
50 mM 0.0471 mL 0.2356 mL 0.4712 mL 0.9423 mL 1.1779 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.4712 mL 0.5889 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of the Korean Society for Applied Biological Chemistry, 2004,47(2):270-3.
Isolation of Antibacterial Prenylated Flavonoids from Cudrania tricuspidata.[Reference: WebLink]

METHODS AND RESULTS:
Two prenylated flavonoids were isolated from a chloroform extract of the root bark of Cudrania tricuspidata. Both compounds (1, 2) showed antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus.
CONCLUSIONS:
Their structures were determined as Euchrestaflavanone B (1) and euchrestaflavanone C (2) on the basis of and long-range coupling NMR techniques.
CFN94881(-)-Sophoranone23057-55-8460.6C30H36O4
CFN965295-Hydroxysophoranone90686-12-7476.61C30H36O5
CFN97893Sanggenol P1351931-30-0492.6C30H36O6
CFN92415(+/-)-Sigmoidin A176046-04-1424.5C25H28O6
CFN95213Licoflavanone119240-82-3340.4C20H20O5
CFN979584'-O-Methyllicoflavanone1038753-13-7354.4C21H22O5
CFN92320Kuwanon E68401-05-8424.5C25H28O6
CFN92695Sanggenol A174423-30-4424.5C25H28O6
CFN97979Sanggenon N92280-12-1422.5C25H26O6
CFN93042Glabrol59870-65-4392.49C25H28O4
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