ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $58.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2016, 21(6)Nat Plants.2016, 3:16205US20170000760 A12016, 42740Int J Mol Sci.2017, 18(5)Integr Med Res.2017, 6(4):395-403RSC Advances2017, 86Food Res Int.2017, 96:40-45J Nat Med.2018, 72(3):734-744
Saf Health Work.2019, 10(2):196-204J Ethnopharmacol.2019, 228:132-141Molecules.2019, 24(2):329Appl. Sci.2020, 10,1304Plant Foods Hum Nutr.2020, 10.1007Biosci. Rep.2020, 10.1024Neurochem Int.2020, 133:104629J Sep Sci.2020, 201901140
Adaptive Medicine 2020, 12(1): 4-10Food Analytical Methods...2020...Molecules.2020, 25(17):3783.J Food Biochem.2020, 44(6):e13198. Medicina (Kaunas).2020, 56(12):685.Reprod Toxicol.2020, 96:1-10. Phytomedicine.2021, 2(82):153452
Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Goias (... (Brazil)Universite de Lille1 (France)Anna University (India)Kamphaengphet Rajabhat University (Thailand)
Universidad Veracuzana (Mexico)Sanford Burnham Medical Researc... (USA)Nicolaus Copernicus Uniwersity (Poland)University of Illinois (USA)
Instituto de Investigaciones Ag... (Chile)University of Lodz (Poland)Univerzita Karlova v Praze (Czech Republic)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Nutr Res Pract.2020, 14(3):203-217.BMC Complement Altern Med.2018, 18(1):303Food Chem.2020, 327:126992.J Sci Food Agric.2018, 98(3):1153-1161Int J Food Sci Nutr.2019, 70(7):825-833Biochemistry.2018, 57(40):5886-5896Food Research International2016, 106-113Appl Microbiol Biotechnol.2016, 100(9):3965-77Foods.2020, 9(10):1348. Food and Fermentation Industries2018, 44(371)
Related Screening Libraries
|| Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
|Evid Based Complement Alternat Med. 2011;2011:624375. |
|Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells.[Pubmed: 20008903]|
|Citrus grandis (L.) Osbeck (red wendun) leaves have been used in traditional Chinese medicine to treat several illnesses including diabetes. However, there is no scientific evidence supporting these actions and its active compounds. Two flavone glycosides, rhoifolin and Cosmosiin were isolated for the first time from red wendun leaves and, identified these leaves are rich source for rhoifolin (1.1%, w/w).|
METHODS AND RESULTS:
In differentiated 3T3-L1 adipocytes, rhoifolin and Cosmosiin showed dose-dependent response in concentration range of o.oo1-5 μM and 1-20 μM, respectively, in biological studies beneficial to diabetes. Particularly, rhoifolin and Cosmosiin at 0.5 and 20 μM, respectively showed nearly similar response to that 10 nM of insulin, on adiponectin secretion level. Furthermore, 5 μM of rhoifolin and 20 μM of Cosmosiin showed equal potential with 10 nM of insulin to increase the phosphorylation of insulin receptor-β, in addition to their positive effect on GLUT4 translocation.
These findings indicate that rhoifolin and Cosmosiin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
||The flowers of Cosmos bipinnatus.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.