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    Natural Products
    Gardenolic acid B
    Information
    CAS No. 108864-53-5 Price
    Catalog No.CFN96838Purity>=98%
    Molecular Weight486.69Type of CompoundTriterpenoids
    FormulaC30H46O5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    Gardenolic acid B

    Gardenolic acid B
    Product Name Gardenolic acid B
    CAS No.: 108864-53-5
    Catalog No.: CFN96838
    Molecular Formula: C30H46O5
    Molecular Weight: 486.69 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Source: The flowers of Gardenia jasminoides ellis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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    Description: Gardenolic acid B shows promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells. Gardenolic acid B shows significant effects on terminating early pregnancy in rats.
    In vitro:
    J Nat Prod. 2009 Jun;72(6):1102-5.
    Cycloartane triterpenoids from Kleinhovia hospita.[Pubmed: 19489592 ]

    METHODS AND RESULTS:
    Four new cycloartane triterpenoids, together with the known Gardenolic acid B, were isolated from Kleinhovia hospita. The triterpenoids (1-3) contain a unique 21,23-diacetal side-chain, while compound 4 contains two alpha,beta-unsaturated ketone moieties. Their structures and relative configurations were determined by spectroscopic methods, including 2D NMR and IR.
    CONCLUSIONS:
    These compounds showed promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
    Gardenolic acid B Description
    Source: The flowers of Gardenia jasminoides ellis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0547 mL 10.2735 mL 20.547 mL 41.0939 mL 51.3674 mL
    5 mM 0.4109 mL 2.0547 mL 4.1094 mL 8.2188 mL 10.2735 mL
    10 mM 0.2055 mL 1.0273 mL 2.0547 mL 4.1094 mL 5.1367 mL
    50 mM 0.0411 mL 0.2055 mL 0.4109 mL 0.8219 mL 1.0273 mL
    100 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.4109 mL 0.5137 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Acta Chimica Sinica, 1987, 45(3):301-304.
    Studies on the chemical constituents of antifertility plant gardenia jasminoides ellis I: The structure of gardenoic acid B, and early pregnancy terminating component.[Reference: WebLink]
    The flowers of G. jasminoides are used in Chinese folk medicine for birth control. EtOAc extract of the flowers showed significant effects on terminating early pregnancy in rats.
    METHODS AND RESULTS:
    Flash column chromatog. separation of the crude extract gave several components among which 2 new cycloartane triterpenoids, namely gardenic acid and Gardenolic acid B (I) were active components. The structure of I, m.p. 214-216℃, [a]D17 + 51.2, C30H46O5, were deduced by spectral analyses on the acid and the diacetate II.
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