ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Chem Biol Interact.2016, 258:59-68Pharm Biol.2017, 55(1):360-366Front Plant Sci.2017, 8:723Nutrients.2018, 10(12)International Food Research Journ...2018...The Journal of Agromedicine and M...2018...Sci Rep. 2018, 462(8)Oncology Letters2018, 4690-4696
Primary and Industrial.2018, 52(11)Front Pharmacol.2018, 9:756Journal of Ginseng Research...2019...Mol Microbiol.2019, 112(1):317-332J Funct Foods2019, 54:449-456Int Immunopharmacol.2019, 71:361-371TCI CO.2019, US20190151281A1Biomolecules.2020, 10(2):E184
Genes Genomics.2020, 10.1007Biochem Biophys Res Commun....2020...Adaptive Medicine 2020, 12(1): 4-10LWT2020, 126:109313LWT2020, 130:109535Biochem Biophys Res Commun....2020...Clin Exp Pharmacol Physiol....2020...
Our products had been exported to the following research institutions and universities, And still growing.
Agricultural Research Organizat... (Israel)Complutense University of Madrid (Spain)University of Cincinnati (USA)University of Minnesota (USA)
University of Hull (United Kingdom)The Australian National University (Australia)Lund University (Sweden)Molecular Biology Institute of ... (Spain)
Centrum Menselijke Erfelijkheid (Belgium)National Cancer Center Research... (Japan)Heidelberg University (Germany)
Related Screening Libraries
||Gelsemiol has neurotrophic factor-potentiating activity, markedly enhances an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of nerve growth factor. |
|J Pharm Pharmacol. 2001 Jun;53(6):915-9. |
|Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells.[Pubmed: 11428671]|
METHODS AND RESULTS:
In PC12D cells, nerve growth factor (NGF) increased the proportion of neurite-bearing cells and made neurites longer. A methanol extract of Verbena littoralis H. B. K. collected in Paraguay only slightly potentiated the proportion of PC12D cells with neurites but markedly increased the length of neurites in the presence of NGF (2 ng mL(-1)). The methanol extract was partitioned between ethyl acetate and water followed by further extraction of water fraction with n-butanol. The potentiating activity of NGF-action was observed in the ethyl acetate and n-butanol fractions. The n-butanol fraction was separated by silica gel chromatography, monitoring the NGF-potentiating activity to give Gelsemiol and 9-hydroxysemperoside aglucone (9-OHSA). Neither compound (30-300 microM) exhibited neurite-inducing activity alone. Gelsemiol (100-300 microM) markedly enhanced an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of NGF (2 ng mL(-1)). Interestingly, in the presence of NGF (2 ng mL(-1)), 9-OHSA (100-300 microM) enhanced the elongation of neurites without affecting the increase in the proportion of cells with neurites.
These results suggested that Gelsemiol and 9-OHSA were major active components of V. littoralis in the NGF-potentiating action. It was possible that the mechanism of neurite elongation by NGF was different from that of the increase in the proportion of neurite-bearing cells, and that 9-OHSA selectively affected the neurite elongation mechanism.
||The herbs of Verbena littoralis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.