Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Grossamide K
    Grossamide K
    Information
    CAS No. N/A Price $390 / 5mg
    Catalog No.CFN94002Purity>=98%
    Molecular Weight491.54Type of CompoundLignans
    FormulaC28H29NO7Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $370 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Aarhus University (Denmark)
  • Nanjing University of Chinese M... (China)
  • Centralised Purchases Unit (CPU... (India)
  • Siksha O Anusandhan University (India)
  • University of Indonesia (Indonesia)
  • Yale University (USA)
  • Wageningen University (Netherlands)
  • University of Otago (New Zealand)
  • Tokyo Woman's Christian University (Japan)
  • National Research Council of Ca... (Canada)
  • Cornell University (USA)
  • More...
  • Package
    Featured Products
    Deapi-platycodin D3

    Catalog No: CFN92269
    CAS No: 67884-05-3
    Price: $238/5mg
    Sinapine

    Catalog No: CFN00092
    CAS No: 18696-26-9
    Price: $88/20mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg
    Pinoresinol diglucoside

    Catalog No: CFN99994
    CAS No: 63902-38-5
    Price: $100/20mg
    Mulberroside F

    Catalog No: CFN90794
    CAS No: 193483-95-3
    Price: $288/10mg
    Niranthin

    Catalog No: CFN98798
    CAS No: 50656-77-4
    Price: $453/5mg
    Isochamaejasmine

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg

    Grossamide K

    Grossamide K
    Product Name Grossamide K
    CAS No.: N/A
    Catalog No.: CFN94002
    Molecular Formula: C28H29NO7
    Molecular Weight: 491.54 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Source: The herbs of Cannabis sativa L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $390 / 5mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Phytomedicine.2016, 23(4):331-9
  • J Nat Prod.2018, 81(4):966-975
  • Food Engineering Progress2019, 23(3)209-216
  • Phytochemistry.2021, 181:112539.
  • BMC Plant Biol.2021, 21(1):60.
  • Plant Direct.2021, 5(4):e00318.
  • Molecules.2020, 25(20):4851.
  • Pak J Pharm Sci.2019, 32(6)
  • Natural Product Communications2021, 16(9):1-10.
  • Pharmaceutics.2021, 13(11):1839.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-melanogenic Compound Library
  • Lignans Compound Library
  • Biological Activity
    Description: Grossamide K exerts a particularly strong anti-melanogenic activity on the cells without high cell toxicity.
    In vitro:
    J Agric Food Chem. 2010 Apr 28;58(8):4779-85.
    Lignans from the tuber-barks of Colocasia antiquorum var. esculenta and their antimelanogenic Activity.[Pubmed: 20359228]
    Colocasia antiquorum var. esculenta , a variant of C. antiquorum , commonly known as "Imperial Taro", is an edible vegetable in many tropical and subtropical regions of the world.
    METHODS AND RESULTS:
    This study with the aim of evaluating the potential of C. antiquorum var. esculenta as a functional food with a depigmenting effect resulted in the identification of a new sesquilignan, named colocasinol A (1), and a new acyclic phenylpropane lignanamide, named cis-Grossamide K (2), together with 10 known compounds (3-12). The identification and structural elucidation of these compounds were based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data analysis as well as high-resolution fast atom bombardment mass spectrometry (FABMS) and electron impact mass spectrometry (EIMS). Quantitation of the melanin contents and cell viability in murine melanocyte melan-a cells was used to assess the antimelanogenic activities of the isolated compounds.
    CONCLUSIONS:
    Among them, cis-Grossamide K (2), isoamericanol A (3), americanol A (4), 2-hydroxy-3,2'-dimethoxy-4'-(2,3-epoxy-1-hydroxypropyl)-5-(3-hydroxy-1-propenyl)biphenyl (5), and (-)-pinoresinol (6) showed inhibitory effects on melanin production. Compounds 2, 5, and 6 exerted a particularly strong antimelanogenic activity on the cells without high cell toxicity (IC(50) = 54.24, 53.49, and 56.26 microM, and LD(50) = 163.60, 110.23, and >500 microM, respectively).
    Grossamide K Description
    Source: The herbs of Cannabis sativa L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Selaginellin

    Catalog No: CFN95030
    CAS No: 941269-84-7
    Price: $/mg
    Isoeuphorbetin

    Catalog No: CFN95207
    CAS No: 50677-55-9
    Price: $318/5mg
    cis-Mulberroside A

    Catalog No: CFN95006
    CAS No: 166734-06-1
    Price: $418/10mg
    Carasiphenol C

    Catalog No: CFN95045
    CAS No: 868168-04-1
    Price: $368/5mg
    Isonardosinone

    Catalog No: CFN95180
    CAS No: 27062-01-7
    Price: $318/10mg
    Caraganaphenol A

    Catalog No: CFN95093
    CAS No: 174916-31-5
    Price: $333/5mg
    Corymboside

    Catalog No: CFN95292
    CAS No: 73543-87-0
    Price: $318/10mg
    Perlolyrine

    Catalog No: CFN95291
    CAS No: 29700-20-7
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0344 mL 10.1721 mL 20.3442 mL 40.6884 mL 50.8606 mL
    5 mM 0.4069 mL 2.0344 mL 4.0688 mL 8.1377 mL 10.1721 mL
    10 mM 0.2034 mL 1.0172 mL 2.0344 mL 4.0688 mL 5.0861 mL
    50 mM 0.0407 mL 0.2034 mL 0.4069 mL 0.8138 mL 1.0172 mL
    100 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.4069 mL 0.5086 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Phytochemistry. 2001 Dec;58(8):1219-23.
    Lignanamides and other phenolic constituents from the bark of kenaf (Hibiscus cannabinus).[Pubmed: 11738411]

    METHODS AND RESULTS:
    Two new acyclic phenylpropane lignanamides, Grossamide K and erythro-canabisine H, and the naphthol glucoside 2,5-dimethyl-3-O-beta-D-glucopyranosylnaphthol, along with six known compounds were isolated from the acetone extract of bark of Hibiscus cannabinus.
    CONCLUSIONS:
    All structures were established by spectroscopic methods including 2D NMR techniques, which allowed the correction of certain previously reported 13C NMR assignments of grossamide.
    Deapi-platycodin D3

    Catalog No: CFN92269
    CAS No: 67884-05-3
    Price: $238/5mg
    Sinapine

    Catalog No: CFN00092
    CAS No: 18696-26-9
    Price: $88/20mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg
    Pinoresinol diglucoside

    Catalog No: CFN99994
    CAS No: 63902-38-5
    Price: $100/20mg
    Mulberroside F

    Catalog No: CFN90794
    CAS No: 193483-95-3
    Price: $288/10mg
    Niranthin

    Catalog No: CFN98798
    CAS No: 50656-77-4
    Price: $453/5mg
    Isochamaejasmine

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg