ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Grossamide K
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $370 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Agronomy2020, 10(10),1489Int J Mol Sci.2021, 22(16):8641.J Sep Sci.2018, 41(9):1938-1946TCI CO.2019, US20190151257A1Srinagarind Medical Journal2017, 32(1)Gene.2022, 815:146178.International Food Research Journ...2018...Int J Mol Sci.2020, 21(24):9369.
Phytother Res.2019, 33(5):1490-1500Front Plant Sci.2021, 12: 648426.Virulence.2018, 9(1):588-603Int J Mol Sci.2021, 22(19):10405.Molecules2022, 27(3),1140.J Chromatogr B Analyt Technol Bio...2020...Antioxidants (Basel).2021, 10(10):1620.Int J Mol Med.2019, 43(6):2516-2522
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Aarhus University (Denmark)Nanjing University of Chinese M... (China)Centralised Purchases Unit (CPU... (India)Siksha O Anusandhan University (India)
University of Indonesia (Indonesia)Yale University (USA)Wageningen University (Netherlands)University of Otago (New Zealand)
Tokyo Woman's Christian University (Japan)National Research Council of Ca... (Canada)Cornell University (USA)
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Grossamide K
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Phytomedicine.2016, 23(4):331-9J Nat Prod.2018, 81(4):966-975Food Engineering Progress2019, 23(3)209-216Phytochemistry.2021, 181:112539. BMC Plant Biol.2021, 21(1):60.Plant Direct.2021, 5(4):e00318.Molecules.2020, 25(20):4851.Pak J Pharm Sci.2019, 32(6)Natural Product Communications2021, 16(9):1-10.Pharmaceutics.2021, 13(11):1839.
Related Screening Libraries
| Description: |
Grossamide K exerts a particularly strong anti-melanogenic activity on the cells without high cell toxicity. |
| In vitro: |
| J Agric Food Chem. 2010 Apr 28;58(8):4779-85. | | Lignans from the tuber-barks of Colocasia antiquorum var. esculenta and their antimelanogenic Activity.[Pubmed: 20359228] | Colocasia antiquorum var. esculenta , a variant of C. antiquorum , commonly known as "Imperial Taro", is an edible vegetable in many tropical and subtropical regions of the world.
METHODS AND RESULTS:
This study with the aim of evaluating the potential of C. antiquorum var. esculenta as a functional food with a depigmenting effect resulted in the identification of a new sesquilignan, named colocasinol A (1), and a new acyclic phenylpropane lignanamide, named cis-Grossamide K (2), together with 10 known compounds (3-12). The identification and structural elucidation of these compounds were based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data analysis as well as high-resolution fast atom bombardment mass spectrometry (FABMS) and electron impact mass spectrometry (EIMS). Quantitation of the melanin contents and cell viability in murine melanocyte melan-a cells was used to assess the antimelanogenic activities of the isolated compounds.
CONCLUSIONS:
Among them, cis-Grossamide K (2), isoamericanol A (3), americanol A (4), 2-hydroxy-3,2'-dimethoxy-4'-(2,3-epoxy-1-hydroxypropyl)-5-(3-hydroxy-1-propenyl)biphenyl (5), and (-)-pinoresinol (6) showed inhibitory effects on melanin production. Compounds 2, 5, and 6 exerted a particularly strong antimelanogenic activity on the cells without high cell toxicity (IC(50) = 54.24, 53.49, and 56.26 microM, and LD(50) = 163.60, 110.23, and >500 microM, respectively). |
|
Grossamide K Description
| Source: |
The herbs of Cannabis sativa L. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.0344 mL |
10.1721 mL |
20.3442 mL |
40.6884 mL |
50.8606 mL |
| 5 mM |
0.4069 mL |
2.0344 mL |
4.0688 mL |
8.1377 mL |
10.1721 mL |
| 10 mM |
0.2034 mL |
1.0172 mL |
2.0344 mL |
4.0688 mL |
5.0861 mL |
| 50 mM |
0.0407 mL |
0.2034 mL |
0.4069 mL |
0.8138 mL |
1.0172 mL |
| 100 mM |
0.0203 mL |
0.1017 mL |
0.2034 mL |
0.4069 mL |
0.5086 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Phytochemistry. 2001 Dec;58(8):1219-23. | | Lignanamides and other phenolic constituents from the bark of kenaf (Hibiscus cannabinus).[Pubmed: 11738411] |
METHODS AND RESULTS:
Two new acyclic phenylpropane lignanamides, Grossamide K and erythro-canabisine H, and the naphthol glucoside 2,5-dimethyl-3-O-beta-D-glucopyranosylnaphthol, along with six known compounds were isolated from the acetone extract of bark of Hibiscus cannabinus.
CONCLUSIONS:
All structures were established by spectroscopic methods including 2D NMR techniques, which allowed the correction of certain previously reported 13C NMR assignments of grossamide. |
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