Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Hannokinol
    Hannokinol
    Information
    CAS No. 79120-40-4 Price $368 / 5mg
    Catalog No.CFN96248Purity>=98%
    Molecular Weight316.4Type of CompoundPhenols
    FormulaC19H24O4Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $312.8 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • CSIRO - Agriculture Flagship (Australia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Monash University Sunway Campus (Malaysia)
  • Rio de Janeiro State University (Brazil)
  • Kitasato University (Japan)
  • Institute of Bioorganic Chemist... (Poland)
  • Charles Sturt University (Denmark)
  • Ain Shams University (Egypt)
  • University of Amsterdam (Netherlands)
  • University of Bordeaux (France)
  • Universidad de Antioquia (Colombia)
  • More...
  • Package
    Featured Products
    Isoquercitrin

    Catalog No: CFN98753
    CAS No: 482-35-9
    Price: $40/20mg
    Syringaresinol-di-O-glucoside

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $188/20mg
    Neocryptotanshinone II

    Catalog No: CFN92160
    CAS No: 27468-20-8
    Price: $536/5mg
    Cyanidin-3-O-glucoside chloride

    Catalog No: CFN99740
    CAS No: 7084-24-4
    Price: $118/20mg
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Bruceine D

    Catalog No: CFN90771
    CAS No: 21499-66-1
    Price: $258/10mg
    Cryptochlorogenic acid

    Catalog No: CFN99117
    CAS No: 905-99-7
    Price: $128/20mg

    Hannokinol

    Hannokinol
    Product Name Hannokinol
    CAS No.: 79120-40-4
    Catalog No.: CFN96248
    Molecular Formula: C19H24O4
    Molecular Weight: 316.4 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Targets: NO
    Source: The herbs of Alnus japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $368 / 5mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Chem Biol Interact.2016, 260:168-175
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Antiviral Res.2013, 98(3):386-93
  • J Pharm Anal.2016, 6(6):363-373
  • Pharmacognosy Magazine2018, 14(56):418-424
  • J Exp Bot.2016, 67(12):3777-88
  • Crystals2020, 10(3), 206.
  • Int Immunopharmacol.2019, 71:22-31
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Inhibitors Compound Library
  • Phenols Compound Library
  • NO Inhibitor Library
  • Biological Activity
    Description: (+)-Hannokinol and MESO-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM.
    Targets: NO
    In vitro:
    Planta Med. 2008 Jun;74(8):867-9.
    Inhibitory constituents of lipopolysaccharide-induced nitric oxide production in BV2 microglia isolated from Amomum tsao-ko.[Pubmed: 18523923 ]
    A methanolic extract of the fruits of AMOMUM TSAO-KO (Zingiberaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia.
    METHODS AND RESULTS:
    Two new bicyclic nonanes characterized as 6,7-dihydroxy-indan-4-carbaldehyde ( 1) and 6-hydroxy-indan-4-carbaldehyde ( 2) were isolated with the eleven known compounds 6,7-dihydroxy-3,7-dimethyloct-2-enoic acid ( 3), tsaokoin ( 4), isotsaokoin ( 5), 8-oxogeraniol ( 6), P-menth-1-ene-5,6-diol ( 7), 3alpha-hydroxycarvotagenone ( 8), tsaokoarylone ( 9), 1,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-heptadien-3one ( 10), (+)-Hannokinol ( 11), MESO-Hannokinol ( 12) and hannokinin ( 13), from the fruits of A. TSAO-KO using bioactivity-guided fractionation.
    CONCLUSIONS:
    All thirteen compounds significantly inhibited lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM.
    Hannokinol Description
    Source: The herbs of Alnus japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    2-Methoxyfuranoguaia-9-ene-8-one

    Catalog No: CFN95220
    CAS No: 88010-62-2
    Price: $318/10mg
    (+)-Lariciresinol 4'-O-beta-D-Gluc...

    Catalog No: CFN95283
    CAS No: 639857-95-7
    Price: $463/5mg
    3,4-Di-O-caffeoylquinic acid methy...

    Catalog No: CFN90856
    CAS No: 114637-83-1
    Price: $388/5mg
    4,4-di(4-hydroxy-3-methoxyphenly)-...

    Catalog No: CFN95200
    CAS No: 913643-31-9
    Price: $368/5mg
    Trifloroside

    Catalog No: CFN96606
    CAS No: 53823-10-2
    Price: $288/10mg
    Platycogenin A

    Catalog No: CFN95240
    CAS No: 1459719-53-9
    Price: $388/5mg
    Methyl 5-O-feruloylquinate

    Catalog No: CFN92445
    CAS No: 154461-64-0
    Price: $516/5mg
    Pueroside C

    Catalog No: CFN95156
    CAS No: 112343-16-5
    Price: $368/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1606 mL 15.8028 mL 31.6056 mL 63.2111 mL 79.0139 mL
    5 mM 0.6321 mL 3.1606 mL 6.3211 mL 12.6422 mL 15.8028 mL
    10 mM 0.3161 mL 1.5803 mL 3.1606 mL 6.3211 mL 7.9014 mL
    50 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.2642 mL 1.5803 mL
    100 mM 0.0316 mL 0.158 mL 0.3161 mL 0.6321 mL 0.7901 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chinese Journal of Experimental Traditional Medical Formulae, 2015 , 21 (3) :37-40.
    Identification of Chemical Constituents Occurring in Leaves of Alpinia officinarum[Reference: WebLink]
    The current study aimed to identify the chemical constituents occurring in the leaves of Alpinia officinarum.
    METHODS AND RESULTS:
    The collected leaves of A. officinarum were dried in an electric thermostatic drying oven at 40° C overnight. The freshly dried leaves were smashed using a universal high-speed smashing machine and then sieved manually by an 80 mesh. The resulting fine powders and residue were mixed evenly. Twelve flavonoids were chrysin,pinocembrin,tectochrysin,apigenin,galangin,3-methylgalangin,acacetin,kaempferol,kaempferide,quercetin,isorhamnetin and rutin,respectively. Four diarylheptanoids included yakuchinone A,oxyphyllacinol,hexahydrocurcumin and Hannokinol.
    CONCLUSIONS:
    Sixteen chemicals were identified using LC-MS / MS and some unknown diarylheptanoids need to be identified in the future.
    Isoquercitrin

    Catalog No: CFN98753
    CAS No: 482-35-9
    Price: $40/20mg
    Syringaresinol-di-O-glucoside

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $188/20mg
    Neocryptotanshinone II

    Catalog No: CFN92160
    CAS No: 27468-20-8
    Price: $536/5mg
    Cyanidin-3-O-glucoside chloride

    Catalog No: CFN99740
    CAS No: 7084-24-4
    Price: $118/20mg
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Bruceine D

    Catalog No: CFN90771
    CAS No: 21499-66-1
    Price: $258/10mg
    Cryptochlorogenic acid

    Catalog No: CFN99117
    CAS No: 905-99-7
    Price: $128/20mg