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    Natural Products
    Iriflophenone
    Information
    CAS No. 52591-10-3 Price
    Catalog No.CFN98864Purity>=98%
    Molecular Weight246.2 Type of CompoundXanthones
    FormulaC13H10O5Physical DescriptionYellow powder
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    Iriflophenone

    Iriflophenone
    Product Name Iriflophenone
    CAS No.: 52591-10-3
    Catalog No.: CFN98864
    Molecular Formula: C13H10O5
    Molecular Weight: 246.2 g/mol
    Purity: >=98%
    Type of Compound: Xanthones
    Physical Desc.: Yellow powder
    Targets: Estrogen receptor | Progestogen receptor
    Source: The herbs of Aquilaria sinensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Xanthones Compound Library
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  • Biological Activity
    Description: Standard reference
    Targets: Estrogen receptor | Progestogen receptor
    In vitro:
    Molecules. 2014 Aug 14;19(8):12304-19.
    Assessment of extraction parameters on antioxidant capacity, polyphenol content, epigallocatechin gallate (EGCG), epicatechin gallate (ECG) and iriflophenone 3-C-β-glucoside of agarwood (Aquilaria crassna) young leaves.[Pubmed: 25153858 ]
    A benzophenone (Iriflophenone 3-C-β-glucoside) from the crude polyphenol extract (CPE) of A. crassna.
    METHODS AND RESULTS:
    2,2'-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity was used to evaluate the antioxidant capacity of the CPE. Experimental results concluded that ethanol concentration and solid-to-solvent ratio had significant effects (p<0.05) on the yields of polyphenol and antioxidant capacity. Extraction time had an insignificant influence on the recovery of EGCG, ECG and Iriflophenone 3-C-β-glucoside, as well as radical scavenging capacity from the CPE. The extraction parameters that exhibited maximum yields were 40% (v/v) ethanol, 1:60 (w/v) for 30 min where the TPC, TFC, TF, DPPH, EGCG, ECG and Iriflophenone 3-C-β-glucoside levels achieved were 183.5 mg GAE/g DW, 249.0 mg QE/g DW, 4.9 mg CE/g DW, 93.7%, 29.1 mg EGCG/g DW, 44.3 mg ECG/g DW and 39.9 mg Iriflophenone 3-C-β-glucoside/g DW respectively. The IC50 of the CPE was 24.6 mg/L.
    In vivo:
    Pharmacogn Mag. 2015 Jan-Mar;11(41):82-9.
    Effects of iriflophenone 3-C-β-glucoside on fasting blood glucose level and glucose uptake.[Pubmed: 25709215]
    One of the biological activities of agar wood (Aquilaria sinensis Lour., Thymelaeaceae), is anti-hyperglycemic activity. The methanolic extract (ME) was proven to possess the fasting blood glucose activity in rat and glucose uptake transportation by rat adipocytes. To determine the decreasing fasting blood glucose level of constituents affordable for in vivo test. If the test was positive, the mechanism which is positive to the ME, glucose transportation, will be performed.
    METHODS AND RESULTS:
    The ME was separated by column chromatography and identified by spectroscopic methods. Mice was used as an animal model (in vivo), and rat adipocytes were used for the glucose transportation activity (in vitro).Iriflophenone 3-C-β-glucoside (IPG) was the main constituent, 3.17%, and tested for the activities. Insulin and the ME were used as positive controls. The ME, IPG and insulin lowered blood glucose levels by 40.3, 46.4 and 41.5%, respectively, and enhanced glucose uptake by 152, 153, and 183%, respectively.
    CONCLUSIONS:
    These findings suggest that IPG is active in lowering fasting blood glucose with potency comparable to that of insulin.
    Iriflophenone Description
    Source: The herbs of Aquilaria sinensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0617 mL 20.3087 mL 40.6174 mL 81.2348 mL 101.5435 mL
    5 mM 0.8123 mL 4.0617 mL 8.1235 mL 16.247 mL 20.3087 mL
    10 mM 0.4062 mL 2.0309 mL 4.0617 mL 8.1235 mL 10.1543 mL
    50 mM 0.0812 mL 0.4062 mL 0.8123 mL 1.6247 mL 2.0309 mL
    100 mM 0.0406 mL 0.2031 mL 0.4062 mL 0.8123 mL 1.0154 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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