Science | Nature | Cell | View More
Natural Products
Isogomisin O
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isogomisin O
Price:
CAS No.: 83916-76-1
Catalog No.: CFN97333
Molecular Formula: C23H28O7
Molecular Weight: 416.5 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The seeds of Schisandra chinensis (Turcz.) Baill.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Siksha O Anusandhan University (India)
  • Universit?t Basel (Switzerland)
  • University of Brasilia (Brazil)
  • Almansora University (Egypt)
  • University of Wisconsin-Madison (USA)
  • VIT University (India)
  • Melbourne University (Australia)
  • Technical University of Denmark (Denmark)
  • Kyoto University (Japan)
  • University of Malaya (Malaysia)
  • Universita' Degli Studi Di Cagl... (Italy)
  • More...
Package
Featured Products
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Ginkgolic acid C17:1

Catalog No: CFN98508
CAS No: 111047-30-4
Price: $218/20mg
9-Hydroxycanthin-6-one

Catalog No: CFN92126
CAS No: 138544-91-9
Price: $ / mg
Cosmosiin

Catalog No: CFN98981
CAS No: 578-74-5
Price: $80/20mg
Catalpol

Catalog No: CFN98251
CAS No: 2415-24-9
Price: $40/20mg
Baicalein

Catalog No: CFN98783
CAS No: 491-67-8
Price: $40/20mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
Morroniside

Catalog No: CFN98161
CAS No: 25406-64-8
Price: $50/20mg
Luteolin 7-diglucuronide

Catalog No: CFN70468
CAS No: 96400-45-2
Price: $ / mg
Ganoderenic acid C

Catalog No: CFN92238
CAS No: 100665-42-7
Price: $338/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Standard reference
In vitro:
Planta Med. 2007 Aug;73(10):1116-26.
Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis.[Pubmed: 17611932]
Plants of the Schisandraceae family contain a variety of pharmacologically active lignans like schizandrin, deoxyschizandrin, deangeloylgomisin B, gomisin A, gomisin O, gamma-schizandrin and Isogomisin O.
METHODS AND RESULTS:
Here we have compared the composition of different polar and non-polar extracts of Schisandra sphenanthera and Schisandra chinensis. We also have screened the extracts for antiproliferative and anti-inflammatory effects in different cell-based and cell-free assays. Extracts produced with the non-polar solvents CO(2), hexane and CO(2)/5% ethanol had a similar composition. In contrast, polar extraction with ethanol provided a considerably higher yield, but a lower content of volatiles and lignans in comparison to the non-polar extracts. The proliferation of the epidermal cell lines HaCaT and A431 was dose-dependently inhibited by both the Schisandra sphenanthera and Schisandra chinensis extracts, the non-polar extracts being superior to the polar ones. The non-polar Schisandra sphenanthera extract was the most active with a half-maximal inhibitory concentration of 20 microg/mL. In a cell-free enzyme inhibition assay with recombinant cyclooxygenase-2 (COX-2) the non-polar Schisandra sphenanthera extract dose-dependently inhibited COX-2 catalysed prostaglandin (PG) production (IC(50) = 0.2 microg/mL). It also reduced the ultraviolet-B (UVB)-induced PGE (2) production (IC(50) = 4 microg/mL) and COX-2 expression in HaCaT keratinocytes.
CONCLUSIONS:
We conclude that non-polar SChisandra extracts obtained by CO(2) extraction might be useful in the prevention and treatment of hyperproliferative and inflammatory skin diseases.
Isogomisin O Description
Source: The seeds of Schisandra chinensis (Turcz.) Baill.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
erythro-Austrobailignan-6

Catalog No: CFN95501
CAS No: 114127-24-1
Price: $318/10mg
Gossypetin 3-sophoroside-8-glucosi...

Catalog No: CFN95528
CAS No: 77306-93-5
Price: $318/5mg
Apigenin 4'-O-(2'',6''-di-O-E-p-co...

Catalog No: CFN95276
CAS No: 71781-79-8
Price: $318/10mg
7-(4-hydroxy-3-methoxyphenyl)-1-ph...

Catalog No: CFN95139
CAS No: 79559-60-7
Price: $268/20mg
Ganoderic acid GS-1

Catalog No: CFN95571
CAS No: 1206781-64-7
Price: $413/5mg
2,6-Dihydroxyacetophenone-4-O-[4',...

Catalog No: CFN95470
CAS No: 1781226-44-5
Price: $318/5mg
New compound 5

Catalog No: CFN95258
CAS No: N/A
Price: $413/5mg
Norwogonin-8-O-glucuronide

Catalog No: CFN95423
CAS No: 118525-47-6
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.401 mL 12.0048 mL 24.0096 mL 48.0192 mL 60.024 mL
5 mM 0.4802 mL 2.401 mL 4.8019 mL 9.6038 mL 12.0048 mL
10 mM 0.2401 mL 1.2005 mL 2.401 mL 4.8019 mL 6.0024 mL
50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9604 mL 1.2005 mL
100 mM 0.024 mL 0.12 mL 0.2401 mL 0.4802 mL 0.6002 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1281-3.
Lignans from Schisandra propinqua var. propinqua.[Pubmed: 17666862]

METHODS AND RESULTS:
Two new dibenzocyclooctadiene lignans angeloyl-(+)-gomisin K(3) (1) and methylIsogomisin O (2), together with six known ones, Isogomisin O, angeloylIsogomisin O, gomisin O, angeloygomisin O, benzoylgomisin O, epigomisin O, and four 1,4-bis(phenyl)-2,3-dimethylbutane type lignans, pregomisin, meso-dihydroguaiaretic acid, isoanwulignan, and sphenanlignan were isolated from the aerial parts of Schisandra propinqua var. propinqua.
CONCLUSIONS:
The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques.
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Ginkgolic acid C17:1

Catalog No: CFN98508
CAS No: 111047-30-4
Price: $218/20mg
9-Hydroxycanthin-6-one

Catalog No: CFN92126
CAS No: 138544-91-9
Price: $ / mg
Cosmosiin

Catalog No: CFN98981
CAS No: 578-74-5
Price: $80/20mg
Catalpol

Catalog No: CFN98251
CAS No: 2415-24-9
Price: $40/20mg
Baicalein

Catalog No: CFN98783
CAS No: 491-67-8
Price: $40/20mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
Morroniside

Catalog No: CFN98161
CAS No: 25406-64-8
Price: $50/20mg
Luteolin 7-diglucuronide

Catalog No: CFN70468
CAS No: 96400-45-2
Price: $ / mg
Ganoderenic acid C

Catalog No: CFN92238
CAS No: 100665-42-7
Price: $338/10mg
Tags: buy Isogomisin O | Isogomisin O supplier | purchase Isogomisin O | Isogomisin O cost | Isogomisin O manufacturer | order Isogomisin O | Isogomisin O distributor