Isosaxalin | CAS:55481-86-2 | Manufacturer ChemFaces

Isosaxalin

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Description:

Isosaxalin, heraclenin and heraclenol 3'-Me ether have melanin biosynthesis inhibitory activities.

In vitro:

Korean Journal of Microbiology & Biotechnology, 2003 , 47 (12) :3829-36.

Melanin biosynthesis inhibitory activities of coumarins isolated from Angelica polymorpha MAXIM[Reference: WebLink]

METHODS AND RESULTS:
During the screening for inhibitors of melanin biosynthesis from plant extract, Angelica polymorpha MAXIM which showed a high lecel of inhibition was selected. The inhibiting substances were purified form methanol extract of Angelica Polymorpha MAXIM followed by silica gel column chromatography and HPLC. The inhibitors were identified as heraclenin, Isosaxalin and heraclenol 3'-Me ether , by spectroscopic methods of ESI-MS, ©öH-NMR,©ö©øC-NMR, DEPT, HMQC and HMBC.
CONCLUSIONS:
These compounds did not have mushroom tyrosinase inhibitory activity, but showed a highly potent melanin biosynthesis inhibition zone in the plate culture of Streptomyces bikiniensis, a bacterium used as an indicator organism in this work. These compounds did not show any growth inhibition against S. bikiniensis at the same concentration of melanin biosynthesis test

Isosaxalin Description

Source:	The roots of Angelica polymorpha Maxim.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Isosaxalin
Price:
CAS No.:	55481-86-2
Catalog No.:	CFN98929
Molecular Formula:	C₁₆H₁₅ClO₅
Molecular Weight:	322.7 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Angelica polymorpha Maxim.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-melanogenic Compound Library Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0989 mL	15.4943 mL	30.9885 mL	61.9771 mL	77.4713 mL
5 mM	0.6198 mL	3.0989 mL	6.1977 mL	12.3954 mL	15.4943 mL
10 mM	0.3099 mL	1.5494 mL	3.0989 mL	6.1977 mL	7.7471 mL
50 mM	0.062 mL	0.3099 mL	0.6198 mL	1.2395 mL	1.5494 mL
100 mM	0.031 mL	0.1549 mL	0.3099 mL	0.6198 mL	0.7747 mL

CFN98758	Imperatorin	482-44-0	270.3	C₁₆H₁₄O₄
CFN98354	Heraclenin	2880-49-1	286.3	C₁₆H₁₄O₅
CFN98890	Isogosferol	53319-52-1	286.3	C₁₆H₁₄O₅
CFN98929	Isosaxalin	55481-86-2	322.7	C₁₆H₁₅ClO₅
CFN98402	Heraclenol	31575-93-6	304.3	C₁₆H₁₆O₆
CFN89405	(-)-Heraclenol	139079-42-8	304.29	C₁₆H₁₆O₆
CFN97112	Heraclenol acetonide	64790-68-7	344.4	C₁₉H₂₀O₆
CFN98410	Heraclenol 3'-O-beta-D-glucopyranoside	32207-10-6	466.4	C₂₂H₂₆O₁₁
CFN97243	Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]	765316-44-7	598.6	C₂₇H₃₄O₁₅
CFN98247	Rivulobirin E	237407-59-9	590.6	C₃₂H₃₀O₁₁