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Isovanillic acid
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Product Name Isovanillic acid
Price: $30 / 20mg
CAS No.: 645-08-9
Catalog No.: CFN92419
Molecular Formula: C8H8O5
Molecular Weight: 168.1 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Senecio scandens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Isovanillic acid shows distinct anti -inflammatory activities with no toxicity on RAW 264.7 macrophage cells.
Targets: Immunology & Inflammation related
In vitro:
Pharmacogn Mag. 2016 Jan;12(Suppl 1):S47-51.
New Isorhamnetin Derivatives from Salsola imbricata Forssk. Leaves with Distinct Anti-inflammatory Activity.[Pubmed: 27041858]

METHODS AND RESULTS:
All chemical structures were identified on the basis of electrospray ionization -mass spectrometry, one- and two-dimension nuclear magnetic resonance. Nine phenolic compounds, among them two new natural products ; isorhamnetin -3-O-β-D-glucuronyl (1′″→4″) glucuronide (1) and its dimethyl ester ; isorhamnetin -3-O-βD-di glucuronate dimethyl ester (2), two isorhamnetin glycosides : Isorhamnetin -3-O-β-D-galactopyranoside (3), isorhamnetin -3-O-β-D-glucopyranoside (4), and isorhamnetin (5). In addition, an alkaloidal phenolic ; trans N-feruloyl tyramine (6), three phenolic acids: Isovanillic acid (7), ferulic acid (8), and p-hydroxy benzoic acid (9) were isolated from salsola imbricata leaves. All compounds were isolated and identified for the first time from this plant except compound (6). The extract and the tested compounds showed distin ct anti -inflammatory activities with no toxicity on RAW 264.7 macrophage cells.
CONCLUSIONS:
Therfore, extract and the tested compounds showed distinct anti-inflammatory activities with no toxicity on RAW 264 so it may become targets for anti -inflammation drugs developmen.
Isovanillic acid Description
Source: The herbs of Senecio scandens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.9488 mL 29.7442 mL 59.4884 mL 118.9768 mL 148.721 mL
5 mM 1.1898 mL 5.9488 mL 11.8977 mL 23.7954 mL 29.7442 mL
10 mM 0.5949 mL 2.9744 mL 5.9488 mL 11.8977 mL 14.8721 mL
50 mM 0.119 mL 0.5949 mL 1.1898 mL 2.3795 mL 2.9744 mL
100 mM 0.0595 mL 0.2974 mL 0.5949 mL 1.1898 mL 1.4872 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhong Yao Cai. 2012 Oct;35(10):1610-4.
Study on chemical composition of ethylacetate fraction from Polygonum amplexicaule var. sinense.[Pubmed: 23627126]
To study chemical composition of ethylacetate fraction from Polygonoum amplexicaule D. Don var. sinense Forb.
METHODS AND RESULTS:
TLC, Normal-phase silica gel column, reveres-phase silica gel column, Sephadex-LH, semi-preparative HPLC column were used to isolate chemical compositions of ethylacetate fraction from Polygonoum var. sinense. RESULTS: Eight compounds were identified as: 1. P-Hydroxybenzoic acid, 2. P-Hydroxybenzoic ethanol, 3. Diisobutyl phthalate, 4. Vanillin, 5. Isovanillic acid, 6.3,4,5-trihydroxy-benzoic acid-butyl ester, 7. 4-hydroxy-3-methoxycinnamic acid, 8. 7-hydroxy-6-methoxycoumarin.
CONCLUSIONS:
Except of Diisobutyl phthalate, the others are isolated for the first from this plant, moreover, Vanillin, Isovanillic acid and P-hydro -xyphenethyl alcohol are gained from genus for the first time.
Zhong Yao Cai. 2013 Nov;36(11):1774-8.
Chemical constituents from the roots of Ilex pubescens.[Pubmed: 24956816]

METHODS AND RESULTS:
The 95% ethanol extract of the plant was separated by silica gel, Sephadex LH-20 and preparative HPLC chromatography. The structures were elucidated based on the physiochemical properties and spectroscopic analysis. Fifteen compounds were isolated and identified as oleuropein(1), oleoside dimethyl ester(2),8 (Z)-nuezhenide(3),3,4-dicaffeoylquinic acid methyl ester(4),3,4,5-tricaffeoylquinic acid methyl ester (5), Isovanillic acid(6), syringic acid(7), 3beta-acetyloleanolic acid (8), 3beta-acetylursolic acid(9), uvaol(10), asiatic acid(11), 2alpha-hydroxyursolic acid(12), oleanolic acid (13), ursolic acid (14), stigmasterol-3-O-beta-D-glucopyranoside (15).
CONCLUSIONS:
Compounds 2,3,8,9 are obtained from this genus for the first time,compounds 5-7,10-12 are isolated from this plant for the first time.
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