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- Product Intended Use
- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
Kauran-16,17-diol (ent-Kauran-16beta,17-diol)
ChemFaces products have been cited in many studies from excellent and top scientific journals
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $159.1 / In-stock |
| Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Our products had been exported to the following research institutions and universities, And still growing.
- Center for protein Engineering ... (Belgium)
- University of British Columbia (Canada)
- University of Wisconsin-Madison (USA)
- University of Virginia (USA)
- Siksha O Anusandhan University (India)
- Leibniz-Institut für Pflanzenb... (Germany)
- Sanford Burnham Medical Researc... (USA)
- Universitas Airlangga (Indonesia)
- Chulalongkorn University (Thailand)
- Instituto Politécnico de Bragan?a (Portugal)
- University of Queensland (Australia)
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- J Ethnopharmacol.2019, 236:31-41
- Pak J Pharm Sci.2019, 32(6):2879-2885
- Univerzita Karlova2022, 173245.
- Journal of Ginseng Research2021, 3 June.
- Virulence.2018, 9(1):588-603
- Front Microbiol.2019, 10:2806
- J. Korean Wood Sci. Technol.2022, 50(5):338-352.
- J Microbiol Biotechnol.2020, 30(2):178-186.
- Org Biomol Chem.2017, 15(31):6483-6492
- J Sep Sci.2019, 42(21):3352-3362
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
| Related Libraries |
|
| Description: |
Kauran-16,17-diol (ent-Kauran-16β,17-diol),a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages |
| In vitro: |
| Apoptosis. 2011 Dec;16(12):1245-1252 | | The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[Pubmed: 21850486] | | ent-Kauranes are diterpene-type compounds commonly found in most plant species, especially from the Euphorbiaceae family. These compounds have been studied due to their anti-inflammatory and anti-tumor properties. Regulation of apoptosis, or programmed cell death, is commonly bypassed by tumoral cells, giving rise to uncontrolled proliferating cells, which eventually become carcinogenic. In a previous work, we showed that both mRNA and protein expression levels of the antiapoptotic gene Bcl-2 are reduced in MCF-7 cancer cells by the effect of the natural diterpene ent-16β-17α-dihydroxykaurane (DHK). This effect was not directly associated with the inactivation of NF-κB, as has been shown with other diterpenes compounds. Herein, we report that DHK is dissociating the Ap2α-Rb activating complex, affecting its binding ability for the Bcl-2 gene promoter. These events down-regulate Bcl-2 and is temporally accompanied by the induction of E2F1 and its target pro-apoptotic gene Puma. Disruption of the Rb-Ap2α activation complex was corroborated by chromatin immunoprecipitation and protein immunolocalization, which also revealed that Ap2α sorts out from the nucleus and relocalizes in the cell periphery. Taken together, our study confirms the regulation of Bcl-2 gene transcription by the Ap2α-Rb complex and describes a singular protein relocalization for Ap2α induced by DHK, implicating a new potential therapeutic target to differentially onset apoptosis in tumor cells. |
|
Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Description
| Source: |
The herbs of Croton laevigatus |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.2626 mL |
16.3132 mL |
32.6264 mL |
65.2529 mL |
81.5661 mL |
| 5 mM |
0.6525 mL |
3.2626 mL |
6.5253 mL |
13.0506 mL |
16.3132 mL |
| 10 mM |
0.3263 mL |
1.6313 mL |
3.2626 mL |
6.5253 mL |
8.1566 mL |
| 50 mM |
0.0653 mL |
0.3263 mL |
0.6525 mL |
1.3051 mL |
1.6313 mL |
| 100 mM |
0.0326 mL |
0.1631 mL |
0.3263 mL |
0.6525 mL |
0.8157 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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