Ligustroflavone | CAS:260413-62-5 | Manufacturer ChemFaces

Ligustroflavone

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $33.5 / In-stock
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Description:

Ligustroflavone shows high antioxidant capacity and is reported to be an AMPK activator, it activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.

Targets:

AMPK | ATP

In vitro:

J Ethnopharmacol. 2000 Jun;70(3):213-7.

Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed: 10837985]

METHODS AND RESULTS:
Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system.
CONCLUSIONS:
Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and Ligustroflavone presented remarkable activity.

Research Journal of Phytochemistry, 2014, 8(4):148-154.

Identification of Glycosil Flavones and Determination in vitro of Antioxidant and Photoprotective Activities of Alternanthera brasiliana L. Kuntze.[Reference: WebLink]

The study Alternanthera brasiliana (L.) Kuntze aims to prove its effectiveness in folk medicine.
METHODS AND RESULTS:
From the study of their chemical constitution were identified by LC-MS technique three glycosylated flavones than were called 2"-O-ramnosylvitexin; 4',5,7-trimethoxy-2"-Oramnosylvitexin and Ligustroflavone. The tests showed high antioxidant capacity of the specie and in small concentrations showed too high levels of photoprotection. In addition its high capacity for photoprotection also paves its use in cosmetology.
CONCLUSIONS:
Alternanthera brasiliana is a species extremely promising with all parameters to become a herbal medicine.

Ligustroflavone Description

Source:	The leaves of Turpinia montana.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Chinese Journal of Experimental Traditional Medical Formulae, 2016(1):18-21.

Assembly of Adiponectin with Ligustroflavone by Activating AMPK.[Reference: WebLink]

To investigate activation mechanism of AMPK [adenosine 5'-monophosphate( AMP)-activated protein kinase] by Ligustroflavone,and explore effect of Ligustroflavone on assembly of adiponectin.
METHODS AND RESULTS:
293 T cells were treated with Ligustroflavone. AMPK phosphorylation and evel of cellular AMP and ATP were examined by western blotting and high performance liquid chromatography( HPLC),respectively. 3T3-L1 adipocyte was treated by Ligustroflavone and its effect on assembly of adiponectin was detected. Ligustroflavone can activate AMPK and increase ratio of AMP / ATP in 293 T cells.Ligustroflavone also can promote ssembly of adiponectin multimers.
CONCLUSIONS:
Ligustroflavone activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.

Structure Identification:

Pharmazie. 2000 Jan;55(1):78-80.

Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L.[Pubmed: 10683879]

A new flavone, apigenin-7-O-beta-(2",6"-di-alpha-rhamnopyranosyl)-glucopyranoside , named Ligustroflavone, was isolated from the leaves of common privet (Ligustrum vulgare L., Oleaceae), whose popular use was well known in the Mediterranean historical medicine and ethnomedicine as anti-inflammatory. The structures of other five apigenin and luteolin derivates, isolated from the polar fractions of the methanolic leaf extracts, were elucidated.

Product Name	Ligustroflavone
Price:	$60 / 20mg
CAS No.:	260413-62-5
Catalog No.:	CFN90224
Molecular Formula:	C₃₃H₄₀O₁₈
Molecular Weight:	724.67 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The leaves of Turpinia montana.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Flavonoids Compound Library AMPK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3799 mL	6.8997 mL	13.7994 mL	27.5988 mL	34.4985 mL
5 mM	0.276 mL	1.3799 mL	2.7599 mL	5.5198 mL	6.8997 mL
10 mM	0.138 mL	0.69 mL	1.3799 mL	2.7599 mL	3.4498 mL
50 mM	0.0276 mL	0.138 mL	0.276 mL	0.552 mL	0.69 mL
100 mM	0.0138 mL	0.069 mL	0.138 mL	0.276 mL	0.345 mL

CFN70289	Chamaemeloside	173356-77-9	576.5	C₂₇H₂₈O₁₄
CFN98500	Apigenin-7-glucuronide	29741-09-1	446.36	C₂₁H₁₈O₁₁
CFN98894	Apigenin 7-O-methylglucuronide	53538-13-9	460.4	C₂₂H₂₀O₁₁
CFN95648	Apigenin 7,4'-diglucoside	31737-50-5	594.5	C₂₇H₃₀O₁₅
CFN98352	Apigenin 5-O-beta-D-glucopyranoside	28757-27-9	432.4	C₂₁H₂₀O₁₀
CFN90165	Apiin	26544-34-3	564.49	C₂₆H₂₈O₁₄
CFN95352	Apigenin 7-[rhamnosyl-(1->2)-galacturonide]	124167-97-1	592.5	C₂₇H₂₈O₁₅
CFN91599	Apigenin 7-diglucuronide	74696-01-8	622.5	C₂₇H₂₆O₁₇
CFN95371	New compound 12 (Rhoifolin analog)	N/A	722.7	C₃₃H₃₈O₁₈
CFN99814	Rhoifolin	17306-46-6	578.5	C₂₇H₃₀O₁₄