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    Natural Products
    Ligustroflavone
    Information
    CAS No. 260413-62-5 Price $138 / 20mg
    Catalog No.CFN90224Purity>=98%
    Molecular Weight724.67Type of CompoundFlavonoids
    FormulaC33H40O18Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $77.1 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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    Related Libraries
  • Antioxidants Compound Library
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  • Biological Activity
    Description: Ligustroflavone shows high antioxidant capacity and is reported to be an AMPK activator, it activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.
    Targets: AMPK | ATP
    In vitro:
    J Ethnopharmacol. 2000 Jun;70(3):213-7.
    Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed: 10837985]

    METHODS AND RESULTS:
    Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system.
    CONCLUSIONS:
    Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and Ligustroflavone presented remarkable activity.
    Research Journal of Phytochemistry, 2014, 8(4):148-154.
    Identification of Glycosil Flavones and Determination in vitro of Antioxidant and Photoprotective Activities of Alternanthera brasiliana L. Kuntze.[Reference: WebLink]
    The study Alternanthera brasiliana (L.) Kuntze aims to prove its effectiveness in folk medicine.
    METHODS AND RESULTS:
    From the study of their chemical constitution were identified by LC-MS technique three glycosylated flavones than were called 2"-O-ramnosylvitexin; 4',5,7-trimethoxy-2"-Oramnosylvitexin and Ligustroflavone. The tests showed high antioxidant capacity of the specie and in small concentrations showed too high levels of photoprotection. In addition its high capacity for photoprotection also paves its use in cosmetology.
    CONCLUSIONS:
    Alternanthera brasiliana is a species extremely promising with all parameters to become a herbal medicine.
    Ligustroflavone Description
    Source: The leaves of Turpinia montana.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

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    IF=14.548(2019)

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3799 mL 6.8997 mL 13.7994 mL 27.5988 mL 34.4985 mL
    5 mM 0.276 mL 1.3799 mL 2.7599 mL 5.5198 mL 6.8997 mL
    10 mM 0.138 mL 0.69 mL 1.3799 mL 2.7599 mL 3.4498 mL
    50 mM 0.0276 mL 0.138 mL 0.276 mL 0.552 mL 0.69 mL
    100 mM 0.0138 mL 0.069 mL 0.138 mL 0.276 mL 0.345 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Chinese Journal of Experimental Traditional Medical Formulae, 2016(1):18-21.
    Assembly of Adiponectin with Ligustroflavone by Activating AMPK.[Reference: WebLink]
    To investigate activation mechanism of AMPK [adenosine 5'-monophosphate( AMP)-activated protein kinase] by Ligustroflavone,and explore effect of Ligustroflavone on assembly of adiponectin.
    METHODS AND RESULTS:
    293 T cells were treated with Ligustroflavone. AMPK phosphorylation and evel of cellular AMP and ATP were examined by western blotting and high performance liquid chromatography( HPLC),respectively. 3T3-L1 adipocyte was treated by Ligustroflavone and its effect on assembly of adiponectin was detected. Ligustroflavone can activate AMPK and increase ratio of AMP / ATP in 293 T cells.Ligustroflavone also can promote ssembly of adiponectin multimers.
    CONCLUSIONS:
    Ligustroflavone activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.
    Structure Identification:
    Pharmazie. 2000 Jan;55(1):78-80.
    Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L.[Pubmed: 10683879]
    A new flavone, apigenin-7-O-beta-(2",6"-di-alpha-rhamnopyranosyl)-glucopyranoside , named Ligustroflavone, was isolated from the leaves of common privet (Ligustrum vulgare L., Oleaceae), whose popular use was well known in the Mediterranean historical medicine and ethnomedicine as anti-inflammatory. The structures of other five apigenin and luteolin derivates, isolated from the polar fractions of the methanolic leaf extracts, were elucidated.