Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Linderalactone
    Information
    CAS No. 728-61-0 Price $198 / 20mg
    Catalog No.CFN99761Purity>=98%
    Molecular Weight244.29Type of CompoundSesquiterpenoids
    FormulaC15H16O3Physical DescriptionCryst.
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $58.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Griffith University (Australia)
  • University of Wuerzburg (Germany)
  • University of Ioannina (Greece)
  • Florida A&M University (USA)
  • Stanford University (USA)
  • Kyushu University (Japan)
  • National Chung Hsing University (Taiwan)
  • University of Melbourne (Australia)
  • Seoul National University (Korea)
  • Anna University (India)
  • More...
  • Package
    Featured Products
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    20-Deoxocarnosol

    Catalog No: CFN92175
    CAS No: 94529-97-2
    Price: $463/5mg
    3-Oxosapriparaquinone

    Catalog No: CFN92176
    CAS No: 119139-56-9
    Price: $488/5mg
    Hannokinol

    Catalog No: CFN96248
    CAS No: 79120-40-4
    Price: $368/5mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $318/5mg
    Tanshinone IIB

    Catalog No: CFN99820
    CAS No: 17397-93-2
    Price: $463/5mg

    Linderalactone

    Linderalactone
    Product Name Linderalactone
    CAS No.: 728-61-0
    Catalog No.: CFN99761
    Molecular Formula: C15H16O3
    Molecular Weight: 244.29 g/mol
    Purity: >=98%
    Type of Compound: Sesquiterpenoids
    Physical Desc.: Cryst.
    Targets: Immunology & Inflammation related
    Source: The roots of Lindera aggregata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $198 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Pharmaceutics2022, 14(2),376.
  • Journal of Ginseng Research2019, 10.1016
  • Bio-protocol2018, 9(14):e3301
  • Acta horticulturae2017, 1158:257-268
  • APMIS.2019, 127(10):688-695
  • Neuropharmacology.2018, 131:68-82
  • Antioxidants (Basel).2021, 10(8):1300.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Immunomodulators Compound Library
  • Sesquiterpenoids Compound Library
  • Immunology & Inflammation related Inhibitor Library
  • Biological Activity
    Description: Linderalactone shows hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with the EC(50) value of 98.0 microM. It shows significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, the IC50 is 8.48 microg/mL.
    Targets: Immunology & Inflammation related
    In vitro:
    Nat Prod Res. 2005 Apr;19(3):283-6.
    Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma.[Pubmed: 15702642]

    METHODS AND RESULTS:
    Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), Linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities.
    CONCLUSIONS:
    Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 microg/mL, respectively.
    Linderalactone Description
    Source: The roots of Lindera aggregata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Dioscoreside C

    Catalog No: CFN95345
    CAS No: 344912-80-7
    Price: $318/5mg
    Patulitrin

    Catalog No: CFN95153
    CAS No: 19833-25-1
    Price: $398/5mg
    Gypenoside XIII

    Catalog No: CFN95239
    CAS No: 80325-22-0
    Price: $318/5mg
    cis-Mulberroside A

    Catalog No: CFN95006
    CAS No: 166734-06-1
    Price: $418/10mg
    7,2',4'-Trihydroxy-5-methoxy-3-ary...

    Catalog No: CFN95070
    CAS No: 1092952-62-9
    Price: $ / mg
    Rhamnetin 3-galactoside

    Catalog No: CFN95116
    CAS No: 62858-07-5
    Price: $318/5mg
    24-Hydroxymomordicine III

    Catalog No: CFN95169
    CAS No: N/A
    Price: $318/5mg
    Astin C

    Catalog No: CFN95189
    CAS No: 148057-23-2
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0935 mL 20.4675 mL 40.935 mL 81.8699 mL 102.3374 mL
    5 mM 0.8187 mL 4.0935 mL 8.187 mL 16.374 mL 20.4675 mL
    10 mM 0.4093 mL 2.0467 mL 4.0935 mL 8.187 mL 10.2337 mL
    50 mM 0.0819 mL 0.4093 mL 0.8187 mL 1.6374 mL 2.0467 mL
    100 mM 0.0409 mL 0.2047 mL 0.4093 mL 0.8187 mL 1.0234 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2009 Aug;72(8):1497-501.
    Sesquiterpene lactones from the root tubers of Lindera aggregata.[Pubmed: 19639966]
    Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neoLinderalactone, and Linderalactone.
    METHODS AND RESULTS:
    The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Linderagalactone A (1) is a halogenated sesquiterpene lactone possessing a unique rearranged carbon skeleton. Linderagalactone E (5), linderane, hydroxylindestenolide, and Linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.0, 42.4, and 98.0 microM, respectively.
    Zhongguo Zhong Yao Za Zhi. 2001 Nov;26(11):765-7.
    Studies on constituents of the leaves of Lindera aggregata (Sims) Kosterm.[Pubmed: 12776349]
    To study the antibacterial and anti-inflammatory constituents of the leaves of Lindera aggrega.
    METHODS AND RESULTS:
    Compounds were isolated by colum chromatography, and the structures were identified by spectroscopic methods. Six compounds were isolated and identified as mixture of 6-Acetyllindenanolide B-1 and B-2(I), dehydrolindestrenolide (II), hydroxylinderstrenolide (III), Linderalactone (IV), kameofero (V), beta-sitosterol (VI).
    CONCLUSIONS:
    These compounds were obtained from the leaves of Lindera aggregata for the first time.
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    20-Deoxocarnosol

    Catalog No: CFN92175
    CAS No: 94529-97-2
    Price: $463/5mg
    3-Oxosapriparaquinone

    Catalog No: CFN92176
    CAS No: 119139-56-9
    Price: $488/5mg
    Hannokinol

    Catalog No: CFN96248
    CAS No: 79120-40-4
    Price: $368/5mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $318/5mg
    Tanshinone IIB

    Catalog No: CFN99820
    CAS No: 17397-93-2
    Price: $463/5mg