ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $58.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Biochem Mol Toxicol....2021...Molecules.2019, 24(7):E1290Int. J. of Food Properties...2017...Environ Toxicol.2020, doi: 10.1002J Ethnopharmacol.2017, 209:305-316Pharmaceutics.2021, 13(7):1028. Primary and Industrial.2018, 52(11)Phytother Res.2019, 33(4):1104-1113
J Am Soc Mass Spectrom....2021...Asian J Beauty Cosmetol...2016...Front Microbiol.2020, 11:583594.Oncol Rep.2016, 35(3):1356-64Pharmaceutics.2021, 13(11):1839. Pharmaceutics.2021, 13(2):187. Int J Mol Sci.2015, 16(8):18396-411Front Immunol.2020, 11:598556.
Int J Mol Sci.2020, 21(22):8816. Int J Mol Sci.2019, 20(8):E1855Antioxidants (Basel).2020, 9(2): E119Anal Bioanal Chem....2018...J Ethnopharmacol.2020, 249:112396Molecules.2019, 24(19):E3417J Chromatogr Sci.2020, 58(6):485-493.
Our products had been exported to the following research institutions and universities, And still growing.
Leibniz-Institut für Pflanzenb... (Germany)Griffith University (Australia)University of Wuerzburg (Germany)University of Ioannina (Greece)
Florida A&M University (USA)Stanford University (USA)Kyushu University (Japan)National Chung Hsing University (Taiwan)
University of Melbourne (Australia)Seoul National University (Korea)Anna University (India)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Pharmaceutics2022, 14(2),376.Journal of Ginseng Research2019, 10.1016Bio-protocol2018, 9(14):e3301Acta horticulturae2017, 1158:257-268APMIS.2019, 127(10):688-695Neuropharmacology.2018, 131:68-82Antioxidants (Basel).2021, 10(8):1300. J of Health Science and Alternative Medicine2019, 1(1)Plant Foods Hum Nutr.2021, 76(4):472-477.J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
Related Screening Libraries
||Linderalactone shows hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with the EC(50) value of 98.0 microM. It shows significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, the IC50 is 8.48 microg/mL.
||Immunology & Inflammation related|
|Nat Prod Res. 2005 Apr;19(3):283-6. |
|Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma.[Pubmed: 15702642]|
METHODS AND RESULTS:
Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), Linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities.
Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 microg/mL, respectively.
||The roots of Lindera aggregata
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Nat Prod. 2009 Aug;72(8):1497-501. |
|Sesquiterpene lactones from the root tubers of Lindera aggregata.[Pubmed: 19639966]|
Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neoLinderalactone, and Linderalactone.
METHODS AND RESULTS:
The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Linderagalactone A (1) is a halogenated sesquiterpene lactone possessing a unique rearranged carbon skeleton. Linderagalactone E (5), linderane, hydroxylindestenolide, and Linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.0, 42.4, and 98.0 microM, respectively.
|Zhongguo Zhong Yao Za Zhi. 2001 Nov;26(11):765-7. |
|Studies on constituents of the leaves of Lindera aggregata (Sims) Kosterm.[Pubmed: 12776349]|
|To study the antibacterial and anti-inflammatory constituents of the leaves of Lindera aggrega.
METHODS AND RESULTS:
Compounds were isolated by colum chromatography, and the structures were identified by spectroscopic methods.
Six compounds were isolated and identified as mixture of 6-Acetyllindenanolide B-1 and B-2(I), dehydrolindestrenolide (II), hydroxylinderstrenolide (III), Linderalactone (IV), kameofero (V), beta-sitosterol (VI).
These compounds were obtained from the leaves of Lindera aggregata for the first time.