Linolenic acid | CAS:463-40-1 | Manufacturer ChemFaces

Linolenic acid

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Description:

Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women.Alpha-linolenic acid (ALA) reduces cardiovascular disease (CVD) risk, possibly by favorably changing vascular inflammation and endothelial dysfunction. Conjugated linolenic acid shows possible chemopreventive activity in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis.

Targets:

LDL

In vivo:

J. Nutr.,2004 Nov;134(11):2991-7.

Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women.[Pubmed: 15514264]

METHODS AND RESULTS:
Alpha-Linolenic acid (ALA) reduces cardiovascular disease (CVD) risk, possibly by favorably changing vascular inflammation and endothelial dysfunction. Inflammatory markers and lipids and lipoproteins were assessed in hypercholesterolemic subjects (n = 23) fed 2 diets low in saturated fat and cholesterol, and high in PUFA varying in ALA (ALA Diet) and linoleic acid (LA Diet) compared with an average American diet (AAD). The ALA Diet provided 17% energy from PUFA (10.5% LA; 6.5% ALA); the LA Diet provided 16.4% energy from PUFA (12.6% LA; 3.6% ALA); and the AAD provided 8.7% energy from PUFA (7.7% LA; 0.8% ALA). The ALA Diet decreased C-reactive protein (CRP, P < 0.01), whereas the LA Diet tended to decrease CRP (P = 0.08). Although the 2 high-PUFA diets similarly decreased intercellular cell adhesion molecule-1 vs. AAD (-19.1% by the ALA Diet, P < 0.01; -11.0% by the LA Diet, P < 0.01), the ALA Diet decreased vascular cell adhesion molecule-1 (VCAM-1, -15.6% vs. -3.1%, P < 0.01) and E-selectin (-14.6% vs. -8.1%, P < 0.01) more than the LA Diet. Changes in CRP and VCAM-1 were inversely associated with changes in serum eicosapentaenoic acid (EPA) (r = -0.496, P = 0.016; r = -0.418, P = 0.047), or EPA plus docosapentaenoic acid (r = -0.409, P = 0.053; r = -0.357, P = 0.091) after subjects consumed the ALA Diet. The 2 high-PUFA diets decreased serum total cholesterol, LDL cholesterol and triglycerides similarly (P < 0.05); the ALA Diet decreased HDL cholesterol and apolipoprotein AI compared with the AAD (P < 0.05).
CONCLUSIONS:
ALA appears to decrease CVD risk by inhibiting vascular inflammation and endothelial activation beyond its lipid-lowering effects.

Cancer ence, 2010, 93(2):133-142.

Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats.[Pubmed: 11856476]

METHODS AND RESULTS:
The modifying effects of dietary feeding of conjugated Linolenic acid (CLN) isolated from the seeds of bitter gourd (Momordica charantia) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were investigated in male F344 rats to predict its possible cancer chemopreventive efficacy. The effect of CLN on the proliferating cell nuclear antigen (PCNA) index in colonic ACF was also examined. Rats were given subcutaneous injections of AOM (20 mg/kg body weight) once a week for 2 weeks to induce ACF. They also received the experimental diet containing 0.01%, 0.1% or 1% CLN for 5 weeks, starting one week before the first dosing of AOM. AOM exposure produced a substantial number of ACF (108 +/- 21/rat) at the end of the study (week 4). Dietary administration of CLN caused a significant reduction in the frequency of ACF: 87 +/- 14 (19.4% reduction, P < 0.05) at a dose of 0.01%, 69 +/- 28 (36.1% reduction, P < 0.01) at a dose of 0.1% and 40 +/- 6 (63.0% reduction, P < 0.001) at a dose of 1%. Also, CLN administration lowered the PCNA index and induced apoptosis in ACF.
CONCLUSIONS:
These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis.

Linolenic acid Description

Source:	The herbs of Fructus Perillae
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chinese Journal of Pharmaceutical Analysis, 2012,32(2):252-254.

RP-HPLC simultaneous determination of α-linolenic acid and linoleic acid in Fructus Perillae.[Reference: WebLink]

To establish an RP-HPLC method for simultaneous determination of α-Linolenic acid and linoleic acid in Fructus Perillae.
METHODS AND RESULTS:
The separation was carried out on an Agilent Eclipse XDB-C18(150 mm×4.6 mm,5 μm) column with a mixture of acetonitrile-water(90∶ 10) as the mobile phase at the flow rate of 1.0 mL·min-1;The column temperature was maintained at 30 ℃ and the detective wavelength was set at 205 nm. The calibration curves of α-Linolenic acid and linoleic acid were linear in the ranges of 14.45-144.5 μg·mL-1(r=0.9998) and 5.75-57.5 μg·mL-1(r=0.9999),respectively.The average recoveries(n=6) were 100.2%(RSD=2.3%) and 101.2%(RSD=1.5%).
CONCLUSIONS:
The method is simple,rapid and accurate,which is suitable for simultaneous determination of α-Linolenic acid and linoleic acid in Fructus Perillae and Perilla oil.

CAS No.	463-40-1	Price	$30 / 20mg
Catalog No.	CFN70110	Purity	>=98%
Molecular Weight	278.4	Type of Compound	Miscellaneous
Formula	C₁₈H₃₀O₂	Physical Description	Oil
Download	COA MSDS	Similar structural	Comparison

Product Name	Linolenic acid
CAS No.:	463-40-1
Catalog No.:	CFN70110
Molecular Formula:	C₁₈H₃₀O₂
Molecular Weight:	278.4 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Oil
Targets:	LDL
Source:	The herbs of Fructus Perillae
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$30 / 20mg
Download:	COA MSDS
Similar structural:	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Miscellaneous Compound Library LDL Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.592 mL	17.9598 mL	35.9195 mL	71.8391 mL	89.7989 mL
5 mM	0.7184 mL	3.592 mL	7.1839 mL	14.3678 mL	17.9598 mL
10 mM	0.3592 mL	1.796 mL	3.592 mL	7.1839 mL	8.9799 mL
50 mM	0.0718 mL	0.3592 mL	0.7184 mL	1.4368 mL	1.796 mL
100 mM	0.0359 mL	0.1796 mL	0.3592 mL	0.7184 mL	0.898 mL

CFN98978	2-Acetylbenzoic acid	577-56-0	164.2	C₉H₈O₃
CFN99185	Demethoxycurcumin	22608-11-3	338.35	C₂₀H₁₈O₅
CFN60211	AT7519	844442-38-2	382.24	C₁₆H₁₇Cl₂N₅O₂
CFN97958	4'-O-Methyllicoflavanone	1038753-13-7	354.4	C₂₁H₂₂O₅