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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $8.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2020, 25(15):3353.Foods.2022, 12(1):136. Planta Med.2022, a-1876-3009.Pharmaceutics.2020, 12(9):845.Pharmacogn Mag.2015, 11(43):562-6Asian J Beauty Cosmetol...2020...PLoS One.2017, 12(8):e0181191Evid Based Complement Alternat Me...2018...
Functional Ecology2020, doi: 10.1111.Journal of Third Military Medical...2019...Antioxidants (Basel).2020, 9(6):544. Korean Herb. Med. Inf....2020...Food Funct.2022, 13(23):12105-12120.Front Pharmacol.2022, 13:906763.University of Limpopo2016, 1-237Antioxidants (Basel).2019, 8(8):E307
Int J Mol Sci.2022, 23(11):6104. Pharmacol Rep.2017, 69(6):1224-1231Molecules.2022, 27(7):2360.J Mol Histol.2019, 50(4):343-354Korean J. Medicinal Crop Sci....2022...Molecules.2019, 24(11):E2102Appl. Sci.2020, 10(4),1304
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Antioxidants (Basel).2020, 9(11):1121.Front Plant Sci.2018, 9:1424Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.Molecules.2019, 24(2):329Pharmaceutics.2022, 14(5):945.Pharmacognosy Journal2019, 11,6:1235-1241Reprod Toxicol.2020, 96:1-10. Korean J of Pharmacognosy2020, 51,49-54.Asian J of Pharmaceutical&Clinical 2018, 11(2)BMC Complement Altern Med.2017, 17(1):393
Related Screening Libraries
||Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women.Alpha-linolenic acid (ALA) reduces cardiovascular disease (CVD) risk, possibly by favorably changing vascular inflammation and endothelial dysfunction. Conjugated linolenic acid shows possible chemopreventive activity in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis.|
|J. Nutr.,2004 Nov;134(11):2991-7. |
|Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women.[Pubmed: 15514264]|
METHODS AND RESULTS:
Alpha-Linolenic acid (ALA) reduces cardiovascular disease (CVD) risk, possibly by favorably changing vascular inflammation and endothelial dysfunction. Inflammatory markers and lipids and lipoproteins were assessed in hypercholesterolemic subjects (n = 23) fed 2 diets low in saturated fat and cholesterol, and high in PUFA varying in ALA (ALA Diet) and linoleic acid (LA Diet) compared with an average American diet (AAD). The ALA Diet provided 17% energy from PUFA (10.5% LA; 6.5% ALA); the LA Diet provided 16.4% energy from PUFA (12.6% LA; 3.6% ALA); and the AAD provided 8.7% energy from PUFA (7.7% LA; 0.8% ALA). The ALA Diet decreased C-reactive protein (CRP, P < 0.01), whereas the LA Diet tended to decrease CRP (P = 0.08). Although the 2 high-PUFA diets similarly decreased intercellular cell adhesion molecule-1 vs. AAD (-19.1% by the ALA Diet, P < 0.01; -11.0% by the LA Diet, P < 0.01), the ALA Diet decreased vascular cell adhesion molecule-1 (VCAM-1, -15.6% vs. -3.1%, P < 0.01) and E-selectin (-14.6% vs. -8.1%, P < 0.01) more than the LA Diet. Changes in CRP and VCAM-1 were inversely associated with changes in serum eicosapentaenoic acid (EPA) (r = -0.496, P = 0.016; r = -0.418, P = 0.047), or EPA plus docosapentaenoic acid (r = -0.409, P = 0.053; r = -0.357, P = 0.091) after subjects consumed the ALA Diet. The 2 high-PUFA diets decreased serum total cholesterol, LDL cholesterol and triglycerides similarly (P < 0.05); the ALA Diet decreased HDL cholesterol and apolipoprotein AI compared with the AAD (P < 0.05).
ALA appears to decrease CVD risk by inhibiting vascular inflammation and endothelial activation beyond its lipid-lowering effects.
|Cancer ence, 2010, 93(2):133-142. |
|Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats.[Pubmed: 11856476]|
METHODS AND RESULTS:
The modifying effects of dietary feeding of conjugated Linolenic acid (CLN) isolated from the seeds of bitter gourd (Momordica charantia) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were investigated in male F344 rats to predict its possible cancer chemopreventive efficacy. The effect of CLN on the proliferating cell nuclear antigen (PCNA) index in colonic ACF was also examined. Rats were given subcutaneous injections of AOM (20 mg/kg body weight) once a week for 2 weeks to induce ACF. They also received the experimental diet containing 0.01%, 0.1% or 1% CLN for 5 weeks, starting one week before the first dosing of AOM. AOM exposure produced a substantial number of ACF (108 +/- 21/rat) at the end of the study (week 4). Dietary administration of CLN caused a significant reduction in the frequency of ACF: 87 +/- 14 (19.4% reduction, P < 0.05) at a dose of 0.01%, 69 +/- 28 (36.1% reduction, P < 0.01) at a dose of 0.1% and 40 +/- 6 (63.0% reduction, P < 0.001) at a dose of 1%. Also, CLN administration lowered the PCNA index and induced apoptosis in ACF.
These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis.
Linolenic acid Description
||The herbs of Fructus Perillae
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chinese Journal of Pharmaceutical Analysis, 2012,32(2):252-254. |
|RP-HPLC simultaneous determination of α-linolenic acid and linoleic acid in Fructus Perillae.[Reference: WebLink]|
|To establish an RP-HPLC method for simultaneous determination of α-Linolenic acid and linoleic acid in Fructus Perillae. |
METHODS AND RESULTS:
The separation was carried out on an Agilent Eclipse XDB-C18(150 mm×4.6 mm,5 μm) column with a mixture of acetonitrile-water(90∶ 10) as the mobile phase at the flow rate of 1.0 mL·min-1;The column temperature was maintained at 30 ℃ and the detective wavelength was set at 205 nm. The calibration curves of α-Linolenic acid and linoleic acid were linear in the ranges of 14.45-144.5 μg·mL-1(r=0.9998) and 5.75-57.5 μg·mL-1(r=0.9999),respectively.The average recoveries(n=6) were 100.2%(RSD=2.3%) and 101.2%(RSD=1.5%).
The method is simple,rapid and accurate,which is suitable for simultaneous determination of α-Linolenic acid and linoleic acid in Fructus Perillae and Perilla oil.
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