Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Linolenic acid
    Linolenic acid
    Information
    CAS No. 463-40-1 Price $30 / 20mg
    Catalog No.CFN70110Purity>=98%
    Molecular Weight278.4Type of CompoundMiscellaneous
    FormulaC18H30O2Physical DescriptionOil
    Download COA    MSDSSimilar structuralComparison
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $8.9 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Virginia (USA)
  • Martin Luther University of Hal... (Germany)
  • FORTH-IMBB (Greece)
  • Universita' Degli Studi Di Cagl... (Italy)
  • Florida A&M University (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • Universitas Airlangga (Indonesia)
  • University of Lodz (Poland)
  • Universidade da Beira Interior (Germany)
  • Imperial College London (United Kingdom)
  • Weizmann Institute of Science (Israel)
  • More...
  • Package
    Featured Products
    Neochlorogenic acid

    Catalog No: CFN97472
    CAS No: 906-33-2
    Price: $108/20mg
    Picroside III

    Catalog No: CFN99567
    CAS No: 64461-95-6
    Price: $228/20mg
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    Shikonin

    Catalog No: CFN99907
    CAS No: 517-88-4
    Price: $80/20mg
    Nodakenetin

    Catalog No: CFN98788
    CAS No: 495-32-9
    Price: $188/10mg
    Kawain

    Catalog No: CFN92656
    CAS No: 500-64-1
    Price: $100/20mg
    20R-Ginsenoside Rg2

    Catalog No: CFN90412
    CAS No: 80952-72-3
    Price: $298/20mg

    Linolenic acid

    Linolenic acid
    Product Name Linolenic acid
    CAS No.: 463-40-1
    Catalog No.: CFN70110
    Molecular Formula: C18H30O2
    Molecular Weight: 278.4 g/mol
    Purity: >=98%
    Type of Compound: Miscellaneous
    Physical Desc.: Oil
    Targets: LDL
    Source: The herbs of Fructus Perillae
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Antioxidants (Basel).2020, 9(11):1121.
  • Front Plant Sci.2018, 9:1424
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Molecules.2019, 24(2):329
  • Pharmaceutics.2022, 14(5):945.
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Reprod Toxicol.2020, 96:1-10.
  • Korean J of Pharmacognosy2020, 51,49-54.
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • BMC Complement Altern Med.2017, 17(1):393
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Miscellaneous Compound Library
  • LDL Inhibitor Library
  • Biological Activity
    Description: Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women.Alpha-linolenic acid (ALA) reduces cardiovascular disease (CVD) risk, possibly by favorably changing vascular inflammation and endothelial dysfunction. Conjugated linolenic acid shows possible chemopreventive activity in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis.
    Targets: LDL
    In vivo:
    J. Nutr.,2004 Nov;134(11):2991-7.
    Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women.[Pubmed: 15514264]

    METHODS AND RESULTS:
    Alpha-Linolenic acid (ALA) reduces cardiovascular disease (CVD) risk, possibly by favorably changing vascular inflammation and endothelial dysfunction. Inflammatory markers and lipids and lipoproteins were assessed in hypercholesterolemic subjects (n = 23) fed 2 diets low in saturated fat and cholesterol, and high in PUFA varying in ALA (ALA Diet) and linoleic acid (LA Diet) compared with an average American diet (AAD). The ALA Diet provided 17% energy from PUFA (10.5% LA; 6.5% ALA); the LA Diet provided 16.4% energy from PUFA (12.6% LA; 3.6% ALA); and the AAD provided 8.7% energy from PUFA (7.7% LA; 0.8% ALA). The ALA Diet decreased C-reactive protein (CRP, P < 0.01), whereas the LA Diet tended to decrease CRP (P = 0.08). Although the 2 high-PUFA diets similarly decreased intercellular cell adhesion molecule-1 vs. AAD (-19.1% by the ALA Diet, P < 0.01; -11.0% by the LA Diet, P < 0.01), the ALA Diet decreased vascular cell adhesion molecule-1 (VCAM-1, -15.6% vs. -3.1%, P < 0.01) and E-selectin (-14.6% vs. -8.1%, P < 0.01) more than the LA Diet. Changes in CRP and VCAM-1 were inversely associated with changes in serum eicosapentaenoic acid (EPA) (r = -0.496, P = 0.016; r = -0.418, P = 0.047), or EPA plus docosapentaenoic acid (r = -0.409, P = 0.053; r = -0.357, P = 0.091) after subjects consumed the ALA Diet. The 2 high-PUFA diets decreased serum total cholesterol, LDL cholesterol and triglycerides similarly (P < 0.05); the ALA Diet decreased HDL cholesterol and apolipoprotein AI compared with the AAD (P < 0.05).
    CONCLUSIONS:
    ALA appears to decrease CVD risk by inhibiting vascular inflammation and endothelial activation beyond its lipid-lowering effects.
    Cancer ence, 2010, 93(2):133-142.
    Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats.[Pubmed: 11856476]

    METHODS AND RESULTS:
    The modifying effects of dietary feeding of conjugated Linolenic acid (CLN) isolated from the seeds of bitter gourd (Momordica charantia) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were investigated in male F344 rats to predict its possible cancer chemopreventive efficacy. The effect of CLN on the proliferating cell nuclear antigen (PCNA) index in colonic ACF was also examined. Rats were given subcutaneous injections of AOM (20 mg/kg body weight) once a week for 2 weeks to induce ACF. They also received the experimental diet containing 0.01%, 0.1% or 1% CLN for 5 weeks, starting one week before the first dosing of AOM. AOM exposure produced a substantial number of ACF (108 +/- 21/rat) at the end of the study (week 4). Dietary administration of CLN caused a significant reduction in the frequency of ACF: 87 +/- 14 (19.4% reduction, P < 0.05) at a dose of 0.01%, 69 +/- 28 (36.1% reduction, P < 0.01) at a dose of 0.1% and 40 +/- 6 (63.0% reduction, P < 0.001) at a dose of 1%. Also, CLN administration lowered the PCNA index and induced apoptosis in ACF.
    CONCLUSIONS:
    These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis.
    Linolenic acid Description
    Source: The herbs of Fructus Perillae
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    (-)-Cadin-4,10(15)-dien-11-oic aci...

    Catalog No: CFN95246
    CAS No: 1124353-23-6
    Price: $318/5mg
    1-Isomangostin

    Catalog No: CFN95114
    CAS No: 19275-44-6
    Price: $318/5mg
    Tetillapyrone

    Catalog No: CFN95404
    CAS No: 363136-43-0
    Price: $413/5mg
    Malabaricone C

    Catalog No: CFN95475
    CAS No: 63335-25-1
    Price: $318/10mg
    Decuroside I

    Catalog No: CFN95004
    CAS No: 96638-79-8
    Price: $318/5mg
    Bergamjuicin

    Catalog No: CFN95422
    CAS No: 2376307-20-7
    Price: $318/5mg
    8-Hydroxypinoresinol diglucoside

    Catalog No: CFN95083
    CAS No: 112747-99-6
    Price: $318/5mg
    Safflospermidine B

    Catalog No: CFN95254
    CAS No: N/A
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.592 mL 17.9598 mL 35.9195 mL 71.8391 mL 89.7989 mL
    5 mM 0.7184 mL 3.592 mL 7.1839 mL 14.3678 mL 17.9598 mL
    10 mM 0.3592 mL 1.796 mL 3.592 mL 7.1839 mL 8.9799 mL
    50 mM 0.0718 mL 0.3592 mL 0.7184 mL 1.4368 mL 1.796 mL
    100 mM 0.0359 mL 0.1796 mL 0.3592 mL 0.7184 mL 0.898 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chinese Journal of Pharmaceutical Analysis, 2012,32(2):252-254.
    RP-HPLC simultaneous determination of α-linolenic acid and linoleic acid in Fructus Perillae.[Reference: WebLink]
    To establish an RP-HPLC method for simultaneous determination of α-Linolenic acid and linoleic acid in Fructus Perillae.
    METHODS AND RESULTS:
    The separation was carried out on an Agilent Eclipse XDB-C18(150 mm×4.6 mm,5 μm) column with a mixture of acetonitrile-water(90∶ 10) as the mobile phase at the flow rate of 1.0 mL·min-1;The column temperature was maintained at 30 ℃ and the detective wavelength was set at 205 nm. The calibration curves of α-Linolenic acid and linoleic acid were linear in the ranges of 14.45-144.5 μg·mL-1(r=0.9998) and 5.75-57.5 μg·mL-1(r=0.9999),respectively.The average recoveries(n=6) were 100.2%(RSD=2.3%) and 101.2%(RSD=1.5%).
    CONCLUSIONS:
    The method is simple,rapid and accurate,which is suitable for simultaneous determination of α-Linolenic acid and linoleic acid in Fructus Perillae and Perilla oil.
    Neochlorogenic acid

    Catalog No: CFN97472
    CAS No: 906-33-2
    Price: $108/20mg
    Picroside III

    Catalog No: CFN99567
    CAS No: 64461-95-6
    Price: $228/20mg
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    Shikonin

    Catalog No: CFN99907
    CAS No: 517-88-4
    Price: $80/20mg
    Nodakenetin

    Catalog No: CFN98788
    CAS No: 495-32-9
    Price: $188/10mg
    Kawain

    Catalog No: CFN92656
    CAS No: 500-64-1
    Price: $100/20mg
    20R-Ginsenoside Rg2

    Catalog No: CFN90412
    CAS No: 80952-72-3
    Price: $298/20mg
    Tags: buy Linolenic acid | Linolenic acid supplier | purchase Linolenic acid | Linolenic acid cost | Linolenic acid manufacturer | order Linolenic acid | Linolenic acid distributor