ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $114.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Drug Dev Res.2022, 83(7):1673-1682. Front Plant Sci.2020, 10:1705Food Chem.2019, 275:746-753Biochem Biophys Res Commun....2021...Heliyon2022, 8(2):e08866.J Biochem Mol Toxicol.2022, e23211.Anal Chim Acta.2021, 1180:338874.US20170000760 A12016, 42740
Appl. Sci.2020, 10(16),5482.Food and Fermentation Industries...2018...Pharmaceutics.2022, 14(5):945.Braz J Med Biol Res. 2016, 49(7)Food Chem.2021, 377:131976. Acta Edulis Fungi2020, 27(02):63-76.J Neuroinflammation.2020, 17(1):75.J Adv Res.2019, 17:85-94
Food Chem.2020, 327:126992.Neurotoxicology.2022, 91:218-227.Mol Cells.2015, 38(9):765-72Planta Med.2019, 85(4):347-355J Hematol Oncol.2018, 11(1):112Int J Mol Sci.2015, 16(1):1232-51J of Applied Biological Chem....2020...
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Our products had been exported to the following research institutions and universities, And still growing.
University of British Columbia (Canada)The Ohio State University (USA)Korea Food Research Institute(K... (Korea)Charles University in Prague (Czech Republic)
University of Vigo (Spain)Helmholtz Zentrum München (Germany)University of East Anglia (United Kingdom)Celltrion Chemical Research Ins... (Korea)
University of Illinois (USA)Universitas Airlangga (Indonesia)Seoul National University of Sc... (Korea)
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Magnocurarine
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manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
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Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Ethnopharmacol.2019, 228:132-141J Ethnopharmacol.2017, 206:327-336Plant Physiol Biochem.2021, 160:166-174.Sci Rep.2021, 11(1):10931.Crystals2020, 10(3), 206.Molecules.2021, 26(12):3652.Pharmacol Rep.2018, 70(6):1195-1201J Pharmaceutical and Biomedical Analysis2022, 114631.J Sep Sci.2019, 42(21):3352-3362Evid Based Complement Alternat Med.2016, 2016:1739760
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Magnocurarine is a natural product from Magnolia officinalis. |
| In vitro: |
| J Chromatogr Sci. 2016 Aug;54(7):1201-12. | | Effect of Chemical Profiling Change of Processed Magnolia officinalis on the Pharmacokinetic Profiling of Honokiol and Magnolol in Rats.[Pubmed: 27107095 ] |
METHODS AND RESULTS:
The stem of Magnoliae officinalis (MO) cortex is always preliminarily processed before being applied in traditional Chinese medicine. The definite bioavailability of honokiol (HO) and magnolol (MA) in processed MO (PMO) and the effect of chemical profiling change on the pharmacokinetics of HO and MA are always a greater challenge compared with those of MO. Compared with that of MO, the pharmacokinetic profiling of HO and MA in the PMO was significantly changed and the mean Tmax of HO and MA was increased by 31 and 50% (P < 0.05), respectively; the mean AUC0-t and Cmax of HO were increased by 36 and 24% (P < 0.05), respectively. Subsequently, the chemical profiling of MO and PMO was investigated by a simple and rapid LC-Q/TOF-MS coupled with multivariate analysis method. Principal component analysis and hierarchical cluster analysis of the chromatographic data demonstrated that the chemical profiling of PMO was significantly different from that of MO. Eight marker components including six alkaloids (Magnocurarine, magnoflorine, roemerine and three unidentified peaks) and two lignans (obovatol and MA) were screened out by partial least-squares discriminant analysis.
CONCLUSIONS:
The results indicated that the changes of eight marker components of PMO may have an effect on the pharmacokinetic profiles of HO and MA. |
|
Magnocurarine Description
| Source: |
The barks of Magnolia officinalis |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.1807 mL |
15.9033 mL |
31.8066 mL |
63.6132 mL |
79.5165 mL |
| 5 mM |
0.6361 mL |
3.1807 mL |
6.3613 mL |
12.7226 mL |
15.9033 mL |
| 10 mM |
0.3181 mL |
1.5903 mL |
3.1807 mL |
6.3613 mL |
7.9517 mL |
| 50 mM |
0.0636 mL |
0.3181 mL |
0.6361 mL |
1.2723 mL |
1.5903 mL |
| 100 mM |
0.0318 mL |
0.159 mL |
0.3181 mL |
0.6361 mL |
0.7952 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| J Nat Prod. 2011 Nov 28;74(11):2425-30. | | Alkaloids from the Chinese vine Gnetum montanum.[Pubmed: 22040053 ] | During a high-throughput screening campaign of a prefractionated natural product library, fractions from the Chinese vine Gnetum montanum showed in vitro activity against Pseudomonas aeruginosa wild-type strain, PAO1.
METHODS AND RESULTS:
UV-directed isolation of the organic extract from the vine leaves resulted in the purification of the new natural products N-methyllaudanosolinium trifluoroacetate (1), 3'-hydroxy-N,N-dimethylcoclaurinium trifluoroacetate (2), 1,9,10-trihydroxy-2-methoxy-6-methylaporphinium trifluoroacetate (3), and 6a,7-didehydro-1,9,10-trihydroxy-2-methoxy-6-methylaporphinium trifluoroacetate (4). Compound 4 is described here for the first time, and this is the first report of compounds 1-3 as natural products. Compounds 1-3 were found to racemize over time. Starting from commercially available (+)-boldine, through a series of semisynthetic reactions, a mechanism for the racemization of the isolated compounds is proposed.
CONCLUSIONS:
The known natural products (-)-latifolian A (5) and Magnocurarine (6) were also isolated during these studies. The antibacterial activity was explained by the presence of 5, which displayed an IC50 value of 9.8 μM (MIC = 35 μM). |
|
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