ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Mol Med Rep.2014, 9(5):1653-9J Chromatogr Sci.2015, 53(5):824-9Tea Res. Ins. Of China2017, 1-12PLoS One.2017, 12(3):e0173585J Bone Miner Res.2017, 32(12):2415-2430Integr Med Res.2017, 6(4):395-403LWT-Food Science and Technology...2017...Anat Rec2018, 24264
RSC Adv.2018, 32621-32636The Journal of Agromedicine and M...2018...J Agric Food Chem.2018, 66(1):351-358Sci Rep.2018, 8(1)Food and Agriculture Org. Of the ...2019...Int J Mol Sci.2019, 20(8):E1855Molecules.2019, 24(4):E709Journal of Food Hygiene and Safet...2019...
Phytomedicine.2019, 67:153159Sci Rep.2019, 9(1):4342Oxid Med Cell Longev2019, 9056845:13Biomolecules.2020, 10(2):E184Appl. Sci.2020, 10(8),2804Biochem Pharmacol. 2020, 177:114014.Int J Mol Sci.2020, 21(19),7070.
Our products had been exported to the following research institutions and universities, And still growing.
University of Lodz (Poland)Massachusetts General Hospital (USA)Mahatma Gandhi University (India)Medical University of South Car... (USA)
Monash University Malaysia (Malaysia)University of Sao Paulo (Brazil)Institute of Tropical Disease U... (Indonesia)Georgia Institute of Technology (USA)
University of South Australia (Australia)Sri Sai Aditya Institute of Pha... (India)Max-Planck-Insitut (Germany)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Phytomedicine.2019, 55:229-237Molecules.2019, 24(20):3755Chemistry of Natural Compounds2018, 54(3):572–576Srinagarind Medical Journal2017, 32(1)Korean J of Food Science&Technology 2017, 49(2):146-150J Nat Prod.2017, 80(4):854-863Mol Pharm.2018, 15(8):3285-3296The Japan Society for Analytical Chemistry2018, 67(4):201-206Exp Parasitol.2018, 194:67-78J Ethnopharmacol.2017, 198:87-90
Related Screening Libraries
|| Methyl 3-O-feruloylquinate inhibits the activity of bacteria and viruses and to regulate immunity.|
|Yao Xue Xue Bao. 2015 Feb;50(2):207-10. |
|Chemical constituents of the roots of Macleaya microcarpa and activation efficacy of benzophenanthridine alkaloids for the transcription of xbp1 gene.[Pubmed: 25975030]|
|Ongoing study on the chemical constituents of the roots of Macleaya microcarpa led to the isolation of eight compounds of derivatives of triterpenes and organic acids in addition to some previously identified benzophenanthridines.
METHODS AND RESULTS:
The eight compounds were identified by spectroscopic methods as well as comparison with literature values as 1-oxo-2, 22 (30)-hopandien-29-oic acid (1), 3-oxo-12-oleanen-30-oic acid (2), 3α-hydroxy-12-oleanen-30-oic acid (3), 3β-hydroxy-12-oleanen-30-oic acid (4), ferulic acid (5), ferulic acid 4-O-β-D-glucoside (6), 3-O-feruloylquinic acid (7), and Methyl 3-O-feruloylquinate (8). Of which, 1 is a new triterpenoid of hopanes and 2-8 are isolated from M microcarpa for the first time. In order to discover natural active compounds as potential agents of anti-ulcerative colitis (UC), an in vitro drug high-throughput screening model targeted x-box-binding protein 1 (xbp1) was employed to evaluate the activity of the major chemical constituents of M microcarpa.
The result confirmed that two dihydrobenzophenanthridines, dihydrosanguinarine (9) and dihydrochelerythrine (10), showed a certain activity on activating the transcription of xbpl, a transcription factor (TF) associated with the occurrence, development, and potential treatment of UC, with their relative activating ratios being 1.76 and 1.77 times, respectively, as compared with control group.
|Biomed Res Int. 2014;2014:761849. |
|Possible inhibitor from traditional Chinese medicine for the β form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.[Pubmed: 25045698]|
|Recently, an important topic of major depressive disorder (MDD) had been published in 2013. MDD is one of the most prevalent and disabling mental disorders. Consequently, much research is being undertaken into the causes and treatment. It has been found that inhibition of the β form of calcium/calmodulin-dependent protein kinase type II (β-CaMKII) can ameliorate the disorder.
METHODS AND RESULTS:
Upon screening the traditional Chinese medicine (TCM) database by molecular docking, sengesterone, labiatic acid, and Methyl 3-O-feruloylquinate were selected for molecular dynamics.
|Biomed Res Int. 2014;2014:635152. |
|The inhibition of folylpolyglutamate synthetase (folC) in the prevention of drug resistance in Mycobacterium tuberculosis by traditional Chinese medicine.[Pubmed: 25050369]|
|The selected TCM compounds Saussureamine C, Methyl 3-O-feruloylquinate, and Labiatic acid have been found to inhibit the activity of bacteria and viruses and to regulate immunity. We also suggest the possible pathway in protein for each ligand. Compared with the control, similar interactions and structural variations indicate that these compounds might have an effect on Folylpolyglutamate synthetase.
Finally, we suggest Saussureamine C is the best candidate compound as the complex has a high score, maintains its structural composition, and has a larger variation value than the control, thus inhibiting the drug resistance ability of Mycobacterium tuberculosis.
Methyl 3-O-feruloylquinate Description
||The barks of Phellodendron amurense
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.