Science | Nature | Cell | View More
Natural Products
Methyl p-hydroxyphenyllactate
Methyl p-hydroxyphenyllactate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Methyl p-hydroxyphenyllactate
Price:
CAS No.: 51095-47-7
Catalog No.: CFN96379
Molecular Formula: C10H12O4
Molecular Weight: 196.2 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: Solid
Source: The herbs of Crepis crocea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Chiang Mai University (Thailand)
  • Sanford Burnham Prebys Medical ... (USA)
  • Universidade Federal de Pernamb... (Brazil)
  • University of British Columbia (Canada)
  • Istanbul University (Turkey)
  • Anna University (India)
  • University of Vigo (Spain)
  • Universidad Veracuzana (Mexico)
  • S.N.D.T. Women's University (India)
  • Monash University Malaysia (Malaysia)
  • University of Auckland (New Zealand)
  • More...
Package
Featured Products
Bornyl acetate

Catalog No: CFN90494
CAS No: 5655-61-8
Price: $30/20mg
Delphinidin-3-O-glucoside chloride

Catalog No: CFN92038
CAS No: 6906-38-3
Price: $238/10mg
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
beta-Rhamnocitrin

Catalog No: CFN92328
CAS No: 90-19-7
Price: $ / mg
Acteoside

Catalog No: CFN97048
CAS No: 61276-17-3
Price: $60/20mg
Shuterin

Catalog No: CFN91904
CAS No: 105377-77-3
Price: $ / mg
Pelargonidin-3-O-glucoside chloride

Catalog No: CFN92134
CAS No: 18466-51-8
Price: $490/10mg
Myricetin 3-O-beta-D-glucopyranoside

Catalog No: CFN80163
CAS No: 19833-12-6
Price: $413/5mg
8-Prenylnaringenin

Catalog No: CFN92016
CAS No: 53846-50-7
Price: $108/10mg
Senecionine

Catalog No: CFN00417
CAS No: 130-01-8
Price: $ /
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS) suggests that this interaction is responsible for the observed suppression of cell growth.
In vitro:
Chirality. 2003 Oct;15(8):674-9.
Type II estrogen binding site agonist: synthesis and biological evaluation of the enantiomers of methyl-para-hydroxyphenyllactate (MeHPLA).[Pubmed: 12923805 ]
A high-affinity ligand for the type II estrogen binding site (EBS) was identified. Methyl para-hydroxyphenyllactate (Methyl p-hydroxyphenyllactate,MeHPLA) was observed to suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo. The high affinity of MeHPLA for the type II EBS suggests that this interaction is responsible for the observed suppression of cell growth.
METHODS AND RESULTS:
In this study, the enantiomers of MeHPLA were synthesized and separated by three methods and evaluated for biological activity. When the methods were compared, it was found that the method using an optically pure amine to form the diastereomers of the enantiomers gave the superior yield. Binding studies for the enantiomers to the type II EBS showed that the S-MeHPLA had a higher affinity for the binding site. However, higher binding affinity did not translate into superior cell growth suppression. Both enantiomers suppressed cell growth equally.
Methyl p-hydroxyphenyllactate Description
Source: The herbs of Crepis crocea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Crepidiaside B

Catalog No: CFN95432
CAS No: 101921-35-1
Price: $318/10mg
Aromadendrene

Catalog No: CFN95074
CAS No: 489-39-4
Price: $40/20mg
Ganolucidic acid B

Catalog No: CFN95513
CAS No: 98683-75-1
Price: $413/5mg
4,7-Didehydroneophysalin B

Catalog No: CFN95317
CAS No: 134461-76-0
Price: $338/5mg
Methyl ganoderenate D

Catalog No: CFN95572
CAS No: 748136-03-0
Price: $413/5mg
Notoginsenoside L13

Catalog No: CFN95332
CAS No: 2485859-56-9
Price: $318/5mg
Poricoic acid B

Catalog No: CFN95050
CAS No: 137551-39-4
Price: $318/20mg
Vicinin 2

Catalog No: CFN95249
CAS No: 90456-53-4
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0968 mL 25.4842 mL 50.9684 mL 101.9368 mL 127.421 mL
5 mM 1.0194 mL 5.0968 mL 10.1937 mL 20.3874 mL 25.4842 mL
10 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
50 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.0387 mL 2.5484 mL
100 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(19):3800-4.
Chemical constituents from Crepis crocea.[Pubmed: 26975105]

METHODS AND RESULTS:
Thirteen compounds were isolated from the ethyl acetate fraction of Crepis crocea by column chromatographies on silica gel, Sephadex LH-20 and semi-preparative HPLC. The structures were elucidated on the basis of spectral analysis as tectorone I (1), 8β- (2-methyl- 2-hydroxy-3-oxobutanoyloxy) -glucozaluzanin C (2), tectoroside (3), luteolin-7-O-glucoside (4), cosmosiin (5), esculetin (6), 3,4-dihydroxybenzaldehyde (7), trans-4-hydroxycinnamic acid (8), Caffeic acid (9), Methyl p-hydroxyphenyllactate (10), ethylp- hydroxyphenyllactate (11), cis-3,4-dihydroxy-β-ionion (12).
CONCLUSIONS:
All the compounds, except for compounds 4 and 9, were isolated from this plant for the first time, and tectorone I (1) is a new natural product.
Bornyl acetate

Catalog No: CFN90494
CAS No: 5655-61-8
Price: $30/20mg
Delphinidin-3-O-glucoside chloride

Catalog No: CFN92038
CAS No: 6906-38-3
Price: $238/10mg
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
beta-Rhamnocitrin

Catalog No: CFN92328
CAS No: 90-19-7
Price: $ / mg
Acteoside

Catalog No: CFN97048
CAS No: 61276-17-3
Price: $60/20mg
Shuterin

Catalog No: CFN91904
CAS No: 105377-77-3
Price: $ / mg
Pelargonidin-3-O-glucoside chloride

Catalog No: CFN92134
CAS No: 18466-51-8
Price: $490/10mg
Myricetin 3-O-beta-D-glucopyranoside

Catalog No: CFN80163
CAS No: 19833-12-6
Price: $413/5mg
8-Prenylnaringenin

Catalog No: CFN92016
CAS No: 53846-50-7
Price: $108/10mg
Senecionine

Catalog No: CFN00417
CAS No: 130-01-8
Price: $ /
Tags: buy Methyl p-hydroxyphenyllactate | Methyl p-hydroxyphenyllactate supplier | purchase Methyl p-hydroxyphenyllactate | Methyl p-hydroxyphenyllactate cost | Methyl p-hydroxyphenyllactate manufacturer | order Methyl p-hydroxyphenyllactate | Methyl p-hydroxyphenyllactate distributor