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    Natural Products
    Neridienone B
    Neridienone B
    Information
    CAS No. 61671-56-5 Price
    Catalog No.CFN97057Purity>=98%
    Molecular Weight344.5 Type of CompoundSteroids
    FormulaC21H28O4Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Neridienone B

    Neridienone B
    Product Name Neridienone B
    CAS No.: 61671-56-5
    Catalog No.: CFN97057
    Molecular Formula: C21H28O4
    Molecular Weight: 344.5 g/mol
    Purity: >=98%
    Type of Compound: Steroids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The herbs of Nerium indicum Mill.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • Am J Chin Med.2015, 30:1-22
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Acta horticulturae2017, 1158:257-268
  • J Ethnopharmacol.2017, 198:91-97
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • The Korea Journal of Herbology2016, 29-35
  • Nat Prod Communications2018, 10.1177
  • Biochem Pharmacol. 2020, 177:114014.
  • Biomed Sci Letters.2020, 26:319-326
  • SBRAS2016, 12
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-leishmanial Compound Library
  • Steroids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Neridienone B has significant effects on calcein accumulation. Neridienone exhibits significant leishmanicidal activity against amastigotes of L. mexicana.
    Targets: Antifection
    In vitro:
    J Nat Prod. 2007 Jan;70(1):14-8.
    Bioactive pregnanes from Nerium oleander.[Pubmed: 17253842]
    A new cholesterol derivative, pentalinonsterol (cholest-4,20,24-trien-3-one, 1), and a new polyoxygenated pregnane sterol glycoside, pentalinonside (2), together with 18 known compounds, including 14 sterols (3-16), three coumarins (17-19), and a triterpene (20), were isolated from a n-hexane partition of a methanol extract of the roots of the Mexican medicinal plant Pentalinon andrieuxii.
    METHODS AND RESULTS:
    Structure elucidation of compounds 1 and 2 was accomplished by spectroscopic data interpretation. All isolates were evaluated in vitro for their antileishmanial activity. Among these compounds, 6,7-dihydroneridienone (15) was found to be the most potent principle against promastigotes of Leishmania mexicana (L. mexicana). The cholesterol analogue, pentalinonsterol (1), together with two known sterols, 24-methylcholest-4,24(28)-dien-3-one (3) and neridienone (16), also exhibited significant leishmanicidal activity in this same bioassay. Compounds 1, 3, 15, 16, cholest-4-en-3-one (4), and cholest-5,20,24-trien-3β-ol (7), showed strong antileishmanial activity against amastigotes of L. mexicana, and 4 was found to be the most potent agent with an IC(50) value of 0.03μM. All the isolates were also evaluated for their cytotoxicity in non-infected bone marrow-derived macrophages, but none of these compounds was found active towards this cell line.
    CONCLUSIONS:
    The intracellular parasites treated with compounds 1, 3, 4, 15, and 16 were further studied by electron microscopy; morphological abnormalities and destruction of the amastigotes were observed, as a result of treatment with these compounds.
    Phytochemistry. 2012 Oct;82:128-35.
    Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii.[Pubmed: 22840389]
    A new cholesterol derivative, pentalinonsterol (cholest-4,20,24-trien-3-one, 1), and a new polyoxygenated pregnane sterol glycoside, pentalinonside (2), together with 18 known compounds, including 14 sterols (3-16), three coumarins (17-19), and a triterpene (20), were isolated from a n-hexane partition of a methanol extract of the roots of the Mexican medicinal plant Pentalinon andrieuxii.
    METHODS AND RESULTS:
    Structure elucidation of compounds 1 and 2 was accomplished by spectroscopic data interpretation. All isolates were evaluated in vitro for their antileishmanial activity. Among these compounds, 6,7-dihydroneridienone (15) was found to be the most potent principle against promastigotes of Leishmania mexicana (L. mexicana). The cholesterol analogue, pentalinonsterol (1), together with two known sterols, 24-methylcholest-4,24(28)-dien-3-one (3) and neridienone (16), also exhibited significant leishmanicidal activity in this same bioassay. Compounds 1, 3, 15, 16, cholest-4-en-3-one (4), and cholest-5,20,24-trien-3β-ol (7), showed strong antileishmanial activity against amastigotes of L. mexicana, and 4 was found to be the most potent agent with an IC(50) value of 0.03μM. All the isolates were also evaluated for their cytotoxicity in non-infected bone marrow-derived macrophages, but none of these compounds was found active towards this cell line.
    CONCLUSIONS:
    The intracellular parasites treated with compounds 1, 3, 4, 15, and 16 were further studied by electron microscopy; morphological abnormalities and destruction of the amastigotes were observed, as a result of treatment with these compounds.
    Neridienone B Description
    Source: The herbs of Nerium indicum Mill.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9028 mL 14.5138 mL 29.0276 mL 58.0552 mL 72.5689 mL
    5 mM 0.5806 mL 2.9028 mL 5.8055 mL 11.611 mL 14.5138 mL
    10 mM 0.2903 mL 1.4514 mL 2.9028 mL 5.8055 mL 7.2569 mL
    50 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.1611 mL 1.4514 mL
    100 mM 0.029 mL 0.1451 mL 0.2903 mL 0.5806 mL 0.7257 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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