Nodosin | CAS:10391-09-0 | Manufacturer ChemFaces

Nodosin

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Description:

Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.

Targets:

IL Receptor | HO-1

In vitro:

Am J Chin Med. 2010;38(1):127-42.

Anti-inflammatory function of Nodosin via inhibition of IL-2.[Pubmed: 20128050]

In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin.
METHODS AND RESULTS:
In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum.
CONCLUSIONS:
Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.

Nodosin Description

Source:	The herbs of Isodon serra
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

J Gastroenterol Hepatol. 2012 Apr;27(4):832-40.

Preconditioning donor liver with Nodosin perfusion lessens rat ischemia reperfusion injury via heme oxygenase-1 upregulation.[Pubmed: 22098251]

Ischemia reperfusion injury (IRI) remains a major cause of graft injury, dysfunction and even failure post-transplantation. Heme oxygenase 1 (HO-1) has been found to be an attractive target for anti-inflammatory therapies and a potential candidate responsible for cell injury. The objective of this study was to investigate whether preconditioning the donor liver with Nodosin perfusion upregulates HO-1 and then lessens IRI in rat models.
METHODS AND RESULTS:
Wistar rats were divided into four groups: experimental group, control group, positive control group and negative control group in which the donor liver was preconditioned with Nodosin, lactated ringer's solution, cobalt protoporphyrin and zinc protoporphyrin perfusion, respectively. We measured HO-1 expression and enzyme activity in rat livers of each group ex vivo at 0, 1 and 2 h after perfusion. At 1 h after perfusion, donor livers of Wistar rats were transplanted into Sprague-Dawley rats orthotopically. Serum transaminase levels, degree of cell apoptosis and Suzuki's score were used to assess ischemia/reperfusion injury in recipients at 24 h after transplantation. Ex vivo, donor liver preconditioning with Nodosin perfusion induced HO-1 expression and enzyme activity significantly, compared with the control group (P < 0.05). In vivo, serum transaminase levels, cell apoptosis degree and Suzuki's score of representative recipients in the Nodosin group were lower than that in the control group (P < 0.05). Preconditioning with Nodosin perfusion induced HO-1 protein mainly in Kupffer cells.
CONCLUSIONS:
This study suggests that preconditioning with Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.

Product Name	Nodosin
Price:
CAS No.:	10391-09-0
Catalog No.:	CFN99056
Molecular Formula:	C₂₀H₂₆O₆
Molecular Weight:	362.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Isodon serra
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Hepatoprotective Compound Library Diterpenoids Compound Library IL Receptor Inhibitor Library HO-1 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7594 mL	13.7969 mL	27.5938 mL	55.1876 mL	68.9845 mL
5 mM	0.5519 mL	2.7594 mL	5.5188 mL	11.0375 mL	13.7969 mL
10 mM	0.2759 mL	1.3797 mL	2.7594 mL	5.5188 mL	6.8985 mL
50 mM	0.0552 mL	0.2759 mL	0.5519 mL	1.1038 mL	1.3797 mL
100 mM	0.0276 mL	0.138 mL	0.2759 mL	0.5519 mL	0.6898 mL

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CFN92315	Epinodosin	20086-60-6	362.4	C₂₀H₂₆O₆
CFN99056	Nodosin	10391-09-0	362.4	C₂₀H₂₆O₆
CFN97414	Sculponeatin A	85287-60-1	360.4	C₂₀H₂₄O₆
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