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3. Inhibitors
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
PLoS One.2021, 16(6):e0248479. ACS Nano.2018, 12(4):3385-3396British Jou. Med.&Med. Research...2014...Nat Chem Biol.2018, 14(8):760-763J Sep Sci.2018, 41(11):2488-2497J Biomed Sci.2020, 27(1):60.Journal of Life Science2017, 233-240Microb Biotechnol....2021...
Scientific World Journal....2014...BMC Complement Altern Med.2014, 14:352Molecules.2020, 25(23):5609. Pharmacol Rep.2017, 69(6):1224-1231Mol Pharm.2018, 15(8):3285-3296Molecules 2021, 26(4),1092.J Formos Med Assoc....2020...Yakugaku Zasshi.2018, 138(4):571-579
Tea Res. Ins. Of China2017, 1-12Int J Mol Sci.2022, 23(10):5468. Applied Biological Chemistry...2022...Pharmaceutics.2021, 13(11):1839. LWT2021, 150:112021.Biomed Chromatogr.2019, 8:e4774Biomed Chromatogr.2022, 36(11):e5462.
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Our products had been exported to the following research institutions and universities, And still growing.
Universidad de Ciencias y Artes... (Mexico)University of Melbourne (Australia)Lodz University of Technology (Poland)Sri Sai Aditya Institute of Pha... (India)
The Ohio State University (USA)Kyung Hee University (Korea)St. Jude Children Research Hosp... (USA)Georgia Institute of Technology (USA)
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Nodosin
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manager@chemfaces.com
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Front Microbiol.2020, 11:583594.Pharmacogn J.2022, 14(2):350-357Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36Foods.2022, 11(6):882.J. Food Composition and Anal.2022, V 109:104482.Environ Toxicol.2022, 37(3):514-526.Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112Phytomedicine.2018, 47:48-57Front Plant Sci.2022, 13: 905275.Phytomedicine.2021, 84:153501.
Related Screening Libraries
| Description: |
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation. |
| Targets: |
IL Receptor | HO-1 |
| In vitro: |
| Am J Chin Med. 2010;38(1):127-42. | | Anti-inflammatory function of Nodosin via inhibition of IL-2.[Pubmed: 20128050] | In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin.
METHODS AND RESULTS:
In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin.
Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum.
CONCLUSIONS:
Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial. |
|
Nodosin Description
| Source: |
The herbs of Isodon serra |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.7594 mL |
13.7969 mL |
27.5938 mL |
55.1876 mL |
68.9845 mL |
| 5 mM |
0.5519 mL |
2.7594 mL |
5.5188 mL |
11.0375 mL |
13.7969 mL |
| 10 mM |
0.2759 mL |
1.3797 mL |
2.7594 mL |
5.5188 mL |
6.8985 mL |
| 50 mM |
0.0552 mL |
0.2759 mL |
0.5519 mL |
1.1038 mL |
1.3797 mL |
| 100 mM |
0.0276 mL |
0.138 mL |
0.2759 mL |
0.5519 mL |
0.6898 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Animal Research: |
| J Gastroenterol Hepatol. 2012 Apr;27(4):832-40. | | Preconditioning donor liver with Nodosin perfusion lessens rat ischemia reperfusion injury via heme oxygenase-1 upregulation.[Pubmed: 22098251] | Ischemia reperfusion injury (IRI) remains a major cause of graft injury, dysfunction and even failure post-transplantation. Heme oxygenase 1 (HO-1) has been found to be an attractive target for anti-inflammatory therapies and a potential candidate responsible for cell injury. The objective of this study was to investigate whether preconditioning the donor liver with Nodosin perfusion upregulates HO-1 and then lessens IRI in rat models.
METHODS AND RESULTS:
Wistar rats were divided into four groups: experimental group, control group, positive control group and negative control group in which the donor liver was preconditioned with Nodosin, lactated ringer's solution, cobalt protoporphyrin and zinc protoporphyrin perfusion, respectively. We measured HO-1 expression and enzyme activity in rat livers of each group ex vivo at 0, 1 and 2 h after perfusion. At 1 h after perfusion, donor livers of Wistar rats were transplanted into Sprague-Dawley rats orthotopically. Serum transaminase levels, degree of cell apoptosis and Suzuki's score were used to assess ischemia/reperfusion injury in recipients at 24 h after transplantation.
Ex vivo, donor liver preconditioning with Nodosin perfusion induced HO-1 expression and enzyme activity significantly, compared with the control group (P < 0.05). In vivo, serum transaminase levels, cell apoptosis degree and Suzuki's score of representative recipients in the Nodosin group were lower than that in the control group (P < 0.05). Preconditioning with Nodosin perfusion induced HO-1 protein mainly in Kupffer cells.
CONCLUSIONS:
This study suggests that preconditioning with Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation. |
|
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