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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $92.1 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J. Food Composition and Analysis...2022...Front Microbiol.2022, 13:835463.ScientificWorldJournal....2022...Asian Journal of Chemistry...2018...Drug Invention Today...2019...Molecules.2016, 21(10)Cell Death Dis.2019, 10(12):882Appl. Sci.2020, 10,1304
Phytochemistry Letters2017, 449-455Oncol Rep.2021, 46(2):166.Phytother Res.2019, 33(5):1490-1500BMC Complement Altern Med....2017...BMC Complement Altern Med.2014, 14:352Molecules.2019, 24(16):E2985Int Immunopharmacol.2019, 71:22-31Plant Growth Regulation...2020...
Int J Mol Sci.2020, 21(19),7070.Front Pharmacol.2019, 10:1226Front. Plant Sci.2022, 13:757852.Fitoterapia.2022, 105141.Food Res Int.2022, 157:111397.Biomedicines.2022, 10(3):583.JLiquid Chromatography & Related ...2021...
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University of Hawaii Cancer Center (USA)Lodz University of Technology (Poland)University of Madras (India)
Oroxylin A 7-O-beta-D-glucuronide
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Process Biochemistry2019, 85:106-115Mol Neurobiol.2021, 58(8):3665-3676. J Sci Food Agric.2018, 98(3):1153-1161Allergol Immunopathol (Madr).2022, 1;50(4):23-30.Fitoterapia.2021, 153:104995.Nutrients.2022, 14(23):4997. LWT2020, 124:109163International. J. of Food Properties 2017, 20:S131-S140Enzyme and Microbial Technology2022, 110002.Separations2021, 8(6),80.
Related Screening Libraries
||Oroxylin A-7-O-glucuronide and wogonoside should also be served as the chemical markers together with baicalin for the quality control of herbs and proprietary traditional Chinese medicine (PTCM) products of radix Scutellariae.. Oroxylin A 7-O-glucuronide can inhibit total prolyl oligopeptidase (POP) activity.
||IL Receptor | Prolyl oligopeptidase|
|Beijing Da Xue Xue Bao. 2009 Oct 18;41(5):578-84. |
|Flavonoids from Scutellaria baicalensis and their bioactivities.[Pubmed: 19829679]|
|To study the flavonoids of Scutellaria baicalensis and their bioactivities.
METHODS AND RESULTS:
Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro.
Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), Oroxylin A 7-O-beta-D-glucuronide
(8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9).
Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).
|Fitoterapia. 2010 Sep;81(6):552-6. |
|Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers.[Pubmed: 20117183 ]|
|Prolyl oligopeptidase (POP) is a serine protease highly expressed in the brain that hydrolyses peptide bonds at the carboxyl terminal of prolyl residues. There is evidence that this enzyme participates in several functions of the central nervous system. Scutellaria racemosa Pers demonstrated significant and selective POP inhibition.
METHODS AND RESULTS:
Fractionation of the hydroalcoholic extract resulted in the isolation of four main constituents identified for the first time from S. racemosa Pers, the triterpenoid lupeol (1) and the flavonoids oroxylin A (5,7-dihydroxy-6-methoxyflavone, 2), hispidulin (4',5,7-trihydroxy-6-methoxyflavone, 3), and oroxyloside (Oroxylin A 7-O-beta-D-glucuronide, 4). Inhibitory assays indicated that 3 and 4 at a concentration of 100 microM inhibit 43 and 34% of total POP activity, respectively.
Oroxylin A 7-O-beta-D-glucuronide Description
||The roots of Scutellaria regeliana Nakai
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Pharm Biomed Anal. 2009 Oct 15;50(3):298-306. |
|Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix Scutellariae.[Pubmed: 19481403 ]|
METHODS AND RESULTS:
Contents of the six flavones were found to vary significantly among different products with glycosides, such as baicalin, wogonoside and oroxylin A-7-O-glucuronide(Oroxylin A 7-O-beta-D-glucuronide ), in much greater quantity than their corresponding aglycones. In addition to baicalin (18.54+/-0.71%, w/w), the commonly used marker compound for radix Scutellariae, wogonoside (3.54+/-0.18%, w/w) and oroxylin A-7-O-glucuronide (2.84+/-0.14%, w/w) also existed in abundant amount in the reference herb.
Our findings suggested that wogonoside and oroxylin A-7-O-glucuronide should also be served as the chemical markers together with baicalin for the quality control of herbs and PTCM products of radix Scutellariae.
|Plos One, 2013, 8(11):e80197. |
|Molecular modeling reveals the novel inhibition mechanism and binding mode of three natural compounds to staphylococcal α-hemolysin.[Reference: WebLink]|
METHODS AND RESULTS:
In this study, we found that three natural compounds, Oroxylin A 7-O-glucuronide (Oroxylin A 7-O-beta-D-glucuronide ,OLG), Oroxin A (ORA), and Oroxin B (ORB), when inhibiting the hemolytic activity of α-HL, could bind to the “stem” region of α-HL. This was completed using conventional Molecular Dynamics (MD) simulations. By interacting with the novel binding sites of α-HL, the ligands could form strong interactions with both sides of the binding cavity. The results of the principal component analysis (PCA) indicated that because of the inhibitors that bind to the “stem” region of α-HL, the conformational transition of α-HL from the monomer to the oligomer was restricted. This caused the inhibition of the hemolytic activity of α-HL. This novel inhibition mechanism has been confirmed by both the steered MD simulations and the experimental data obtained from a deoxycholate-induced oligomerization assay.
This study can facilitate the design of new antibacterial drugs against S. aureus.
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