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Phlorizin dihydrate
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Product Name Phlorizin dihydrate
Price: $70 / 20mg
CAS No.: 7061-54-3
Catalog No.: CFN90442
Molecular Formula: C21H24O10.2H2O
Molecular Weight: 472.44 g/mol
Purity: >=98%
Type of Compound: Chalcones
Physical Desc.: Powder
Source: The herbs of Prunus armeniaca L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $29.6 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Phlorizin dihydrate can significantly inhibit oxidative DNA damage.
Targets: NO | PGE | NOS | COX
In vitro:
Biochemical Pharmacology Volume 35, Issue 13, 1 July 1986, Pages 2221–2227
Crystal structure of phlorizin and the iodothyronine deiodinase inhibitory activity of phloretin analogues[Reference: WebLink]
Phloretin, a 7,8-dihydrochalcone of plant origin, and the high molecular weight (<15,000) polyphloretinphosphate (PPP) polymers are potent inhibitors of iodothyronine monodeiodinase activity from rat liver microsomal preparations, whereas phlorizin, the 2′-O-glucoside of phloretin, is inactive.
METHODS AND RESULTS:
The polymers, differing in degree of phosphorylation-dependent polymerization, exhibited a concentration-dependent, and ultimately complete, inhibition of deiodinase activity with an IC50 between 0.2 and 0.5 μg PPP/ml. Phloretin inhibition, on the other hand, was cofactor (DTE) competetive, with a Ki = 0.75 μM. 2′,4′,6′,3,4-Pentahydroxychalcone, which has a substitution pattern in the A-ring identical to that of phloretin, was the only active inhibitor (IC50= 8 μM) among several derivatives tested. The phloretin biodegradation products, phloretic acid and phloroglucinol, and its biosynthetic precursors, monomeric cinnamic acid and cinnamic acid derivatives, were inactive in concentrations up to 100 μM. The X-ray crystal structure analysis of Phlorizin dihydrate showed that the molecule is planar and fully extended, similar to the conformation observed in chalcone structures that are characterized by an α, β-unsaturated bond between phenol rings.
CONCLUSIONS:
Comparison of the planar phlorizin crystal structure with a skewed or antiskewed thyroid hormone conformation revealed that the β-D-glucose moiety does not share any of the thyroid hormone's conformational space, and that the best structural homology is found with the antiskewed conformation of 3′,5′,3-triiodothyronine, the natural deiodinase substrate that also inhibits further deiodination.
Korean Journal of Plant Resources Vol.23 No.6, 2010.12, 487-497
Inhibitory Effect of the Phenolic Compounds from Apples Against Oxidative Damage and Inflammation[Reference: WebLink]
ROS have been associated with pathogenic processes including carcinogenesis through direct effect on DNA and play an important role in the pathogenesis of inflammation. Because of many types of phenolic acid derivatives and flavonoids, apples have been one of the human diet since ancient times and are one of the most commonly consumed fruits in worldwide.
METHODS AND RESULTS:
In this study, catechin, chlorogenic acid and Phlorizin dihydrate were purified and identified by HPLC and GC/MS. The contents of catechin, chlorogenic acid and Phlorizin dihydrate were 1.01 ㎎, 7.01 ㎎ and 3.67 ㎎/ ㎏ wet weight, respectively. Catechin and Phlorizin dihydrate were found to significantly inhibit oxidative DNA damage, while chlorogenic did not affect. Also, catechin inhibits NO and PGE₂ production via suppressing iNOS and COX-2 expression. However, chlorogenic acid and Phlorizin dihydrate did not affect.
CONCLUSIONS:
Our results show that catechin may be the most active phenolic compound in anti-oxidative damage and anti-inflammatory effect.
Phlorizin dihydrate Description
Source: The herbs of Prunus armeniaca L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1167 mL 10.5834 mL 21.1667 mL 42.3334 mL 52.9168 mL
5 mM 0.4233 mL 2.1167 mL 4.2333 mL 8.4667 mL 10.5834 mL
10 mM 0.2117 mL 1.0583 mL 2.1167 mL 4.2333 mL 5.2917 mL
50 mM 0.0423 mL 0.2117 mL 0.4233 mL 0.8467 mL 1.0583 mL
100 mM 0.0212 mL 0.1058 mL 0.2117 mL 0.4233 mL 0.5292 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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