Physcion 8-O-beta-D-monoglucoside | CAS:23451-01-6

Physcion 8-O-beta-D-monoglucoside

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Size /Price /Stock	10 mM * 1 mL in DMSO / $198 / In-stock
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Description:

Physcion 8-O-beta-D-monoglucoside has anti-inflammatory activity, it can inhibit TNF-α-induced cytotoxicity and apoptosis in L929 cells via TNF-R1.

Targets:

TNF-α

In vitro:

Anal Bioanal Chem. 2016 Jul;408(19):5359-67.

Identification of a ligand for tumor necrosis factor receptor from Chinese herbs by combination of surface plasmon resonance biosensor and UPLC-MS.[Pubmed: 27225174]

Identification of bioactive compounds directly from complex herbal extracts is a key issue in the study of Chinese herbs.
METHODS AND RESULTS:
The present study describes the establishment and application of a sensitive, efficient, and convenient method based on surface plasmon resonance (SPR) biosensors for screening active ingredients targeting tumor necrosis factor receptor type 1 (TNF-R1) from Chinese herbs. Concentration-adjusted herbal extracts were subjected to SPR binding assay, and a remarkable response signal was observed in Rheum officinale extract. Then, the TNF-R1-bound ingredients were recovered, enriched, and analyzed by UPLC-QTOF/MS. As a result, Physcion 8-O-beta-D-monoglucoside (PMG) was identified as a bioactive compound, and the affinity constant of PMG to TNF-R1 was determined by SPR affinity analysis (K D = 376 nM). Pharmacological assays revealed that PMG inhibited TNF-α-induced cytotoxicity and apoptosis in L929 cells via TNF-R1. Although PMG was a trace component in the chemical constituents of the R. officinale extract, it had considerable anti-inflammatory activities.
CONCLUSIONS:
It was found for the first time that PMG was a ligand for TNF receptor from herbal medicines. The proposed SPR-based screening method may prove to be an effective solution to analyzing bioactive components of Chinese herbs and other complex drug systems. Graphical abstract Scheme of the method based on SPR biosensor for screening and recovering active ingredients from complex herbal extracts and UPLC-MS for identifying them. Scheme of the method based on SPR biosensor for screening and recovering active ingredients from complex herbal extracts and UPLC-MS for identifying them.

Physcion 8-O-beta-D-monoglucoside Description

Source:	The roots and rhizomes of Rheum palmatum L
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Physcion 8-O-beta-D-monoglucoside
Price:	$268 / 5mg
CAS No.:	23451-01-6
Catalog No.:	CFN80399
Molecular Formula:	C₂₂H₂₂O₁₀
Molecular Weight:	446.4 g/mol
Purity:	>=98%
Type of Compound:	Anthraquinones
Physical Desc.:	Powder
Source:	The roots and rhizomes of Rheum palmatum L
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anthraquinones Compound Library TNF-α Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2401 mL	11.2007 mL	22.4014 mL	44.8029 mL	56.0036 mL
5 mM	0.448 mL	2.2401 mL	4.4803 mL	8.9606 mL	11.2007 mL
10 mM	0.224 mL	1.1201 mL	2.2401 mL	4.4803 mL	5.6004 mL
50 mM	0.0448 mL	0.224 mL	0.448 mL	0.8961 mL	1.1201 mL
100 mM	0.0224 mL	0.112 mL	0.224 mL	0.448 mL	0.56 mL

CFN93322	Chrysophanol 1-O-glucoside	4839-60-5	416.38	C₂₁H₂₀O₉
CFN91124	Chrysophanol 1-O-beta-tetraglucoside	120181-08-0	902.8	C₃₉H₅₀O₂₄
CFN93238	Emodin 1-O-beta-D-glucoside	38840-23-2	432.38	C₂₁H₂₀O₁₀
CFN70270	Frangulin B	14101-04-3	402.4	C₂₀H₁₈O₉
CFN70393	Frangulin A	521-62-0	416.4	C₂₁H₂₀O₉
CFN91773	Emodin 6-O-beta-D-glucoside	34298-85-6	432.38	C₂₁H₂₀O₁₀
CFN99572	Emodin-8-beta-D-glucoside	23313-21-5	432.41	C₂₁H₂₀O₁₀
CFN95132	Emodin-8-O-beta-gentiobioside	66466-22-6	594.5	C₂₇H₃₀O₁₅
CFN80399	Physcion 8-O-beta-D-monoglucoside	23451-01-6	446.4	C₂₂H₂₂O₁₀
CFN89023	Physcion 8-O-rutinoside	129393-21-1	592.55	C₂₈H₃₂O₁₄