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    Natural Products
    Pinoresinol diacetate
    Information
    CAS No. 32971-25-8 Price
    Catalog No.CFN98420Purity>=98%
    Molecular Weight442.5 Type of CompoundLignans
    FormulaC24H26O8Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Pinoresinol diacetate

    Pinoresinol diacetate
    Product Name Pinoresinol diacetate
    CAS No.: 32971-25-8
    Catalog No.: CFN98420
    Molecular Formula: C24H26O8
    Molecular Weight: 442.5 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Targets: 伪-glucosidase
    Source: The barks of Eucommia ulmoides Oliver
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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    Description: Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
    Targets: α-glucosidase
    Pinoresinol diacetate Description
    Source: The barks of Eucommia ulmoides Oliver
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2599 mL 11.2994 mL 22.5989 mL 45.1977 mL 56.4972 mL
    5 mM 0.452 mL 2.2599 mL 4.5198 mL 9.0395 mL 11.2994 mL
    10 mM 0.226 mL 1.1299 mL 2.2599 mL 4.5198 mL 5.6497 mL
    50 mM 0.0452 mL 0.226 mL 0.452 mL 0.904 mL 1.1299 mL
    100 mM 0.0226 mL 0.113 mL 0.226 mL 0.452 mL 0.565 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    J. Korean Soc. Appl. Bi., 2014, 57(4):473-9.
    Pinoresinol Diglucoside is Screened as a Putative alpha-Glucosidase Inhibiting Compound in Actinidia arguta leaves.[Reference: WebLink]
    Actinidia arguta leaves are consumed as a popular food material in Korea and have been reported to exert beneficial effects on humans due to its constituent polyphenolic compounds.
    METHODS AND RESULTS:
    In this study, the alpha-glucosidase inhibitory compounds in A. arguta were screened and identified through alpha-glucosidase-guided fractionation and metabolomic analysis. The 50% ethanol extracts of A. arguta showed strong inhibitory effect (32.6%), which was comparable to acarbose as a positive control (30.0%). Through multiple steps of fractionation, pinoresinol diglucoside and fertaric acid were identified as the major potent compounds in A. arguta inhibiting alpha-glucosidase activity by liquid chromatography mass spectrometry analysis and metabolomic comparison. Particularly, because pinoresinol and its glycosides have been demonstrated as alpha-glucosidase inhibitory agents, pinoresinol diglucoside was proposed to be a putative key compound for alpha-glucosidase inhibition in A. arguta.
    CONCLUSIONS:
    This is the first study demonstrating the anti-diabetic effect of a pinoresinol-containing fraction of A. arguta and would be useful for its application as a natural alpha-glucosidase inhibitor.
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