ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $207.4 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Pharmacognosy Journal...2019...Molecules. 2013, 18(11):14105-21J Chromatogr Sci.2015, 53(5):824-9Food Research2021, 5(1):65-71Reprod Toxicol.2020, 96:1-10. Biomed Chromatogr.2016, 30(10):1573-81J Biotechnol.2020, 318:10-19.Pharmaceuticals (Basel). ...2021...
The Korea Journal of Herbology...2020...Food Chem.2018, 262:78-85Molecules.2021, 26(4):1084.BMB Rep.2020, 53(4):218-222.Anticancer Res.2014, 34(7):3505-9The Journal of Supercritical Flui...2021...Analytical sci. & Tech2016, 186-193Chemistry of Plant Materials....2019...
Neurochem Res.2021, s11064-021-03449-0Pathogens.2018, 7(3):E62J of the Korean Society of Cosmet...2019...Journal of Life Science2017, 233-240Phytomedicine.2021, 83:153483. Nutrients.2020, 12(5):1242.Korean J. Medicinal Crop Sci....2021...
Our products had been exported to the following research institutions and universities, And still growing.
Monash University Malaysia (Malaysia)Universidade Católica Portuguesa (Portugal)Universidad de Buenos Aires (Argentina)Johannes Gutenberg University M... (Germany)
Kazusa DNA Research Institute (Japan)University of Canterbury (New Zealand)Universitas Airlangga (Indonesia)University of Wisconsin-Madison (USA)
Universitas islam negeri Jakarta (Indonesia)Medical University of South Car... (USA)Funda??o Universitária de Dese... (Brazil)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Plant Methods.2017, 13:108J Food Sci.2021, 86(9):3810-3823.Front Microbiol.2020, 11:583594.Environ Toxicol.2021, 36(9):1848-1856.Int J Pharmacol2020, 16:1-9United States Patent Application2020, 20200038363Heinrich Heine University Dusseldorf2021, 62203.Korean J Dent Mater2020, 47(2):63-70.Life Sci.2019, 216:259-270Food Res Int.2017, 96:40-45
Related Screening Libraries
|| Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, suggests that mulberroside F may be used as a skin whitening agent.|
|Biol Pharm Bull. 2002 Aug;25(8):1045-8. |
|Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis.[Pubmed: 12186407]|
METHODS AND RESULTS:
The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3'-di-O-beta-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against auto-oxidation. But its activity was low and was weaker than of kojic acid.
These results suggest that Mulberroside F isolated from mulberry leaves might be used as a skin whitening agent.
|J Agric Food Chem . 2012 Mar 7;60(9):2299-308. |
|In vitro pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (Morus alba L.), and its bacterial metabolite oxyresveratrol in traditional oral use[Pubmed: 22225542]|
Mulberroside A (MulA) is one of the main bioactive constituents in mulberry (Morus alba L.). This study examined the determining factors for previously reported oral pharmacokinetic profiles of MulA and its bacterial metabolite oxyresveratrol (OXY) on in vitro models. When incubated anaerobically with intestinal bacteria, MulA underwent rapid deglycosylation and generated two monoglucosides and its aglycone OXY sequentially. MulA exhibited a poor permeability and predominantly traversed Caco-2 cells via passive diffusion; yet, the permeation of OXY across Caco-2 cells was much more rapid and involved efflux (both p-glycoprotein and MRPs)-mediated mechanisms. Moreover, OXY underwent extensive hepatic glucuronidation; yet, the parent MulA was kept intact in liver subcellular preparations. There was insignificant species difference in intestinal bacterial conversion of MulA and the extent of OXY hepatic glucuronidation between humans and rats, while OXY exhibited a distinct positional preference of glucuronidation in the two species. Overall, these findings revealed a key role of intestinal bacterial conversion in absorption and systemic exposure of MulA and its resultant bacterial metabolite OXY in oral route in humans and rats and warranted further investigational emphasis on OXY and its hepatic metabolites for understanding the benefits of mulberry.|
Mulberroside F Description
||The root barks of Morus alba L.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.