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Pteroic acid
Pteroic acid
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CAS No. 119-24-4 Price
Catalog No.CFN91587Purity>=98%
Molecular Weight312.28Type of CompoundAlkaloids
FormulaC14H12N6O3Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison
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    Pteroic acid

    Pteroic acid
    Product Name Pteroic acid
    CAS No.: 119-24-4
    Catalog No.: CFN91587
    Molecular Formula: C14H12N6O3
    Molecular Weight: 312.28 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source:
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Download: COA    MSDS
    Similar structural: Comparison
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    product package
  • Applied Biological Chemistry2020, 63:37.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Pteroic acid causes greater stimulation of FPGS, including glutamylation of tetrahydrofolate, at neutral pH values (i.e., below the pH optimum of 8.4).
    In vivo:
    J Am Chem Soc . 2005 May 25;127(20):7421-7426.
    Targeting the tumor-associated folate receptor with an 111In-DTPA conjugate of pteroic acid[Pubmed: 15898791]
    The cell membrane folate receptor is a potential molecular target for tumor-selective drug delivery. To probe structural requirements for folate receptor targeting with low molecular weight radiometal chelates, specifically the role of the amino acid fragment of folic acid (pteroylglutamic acid) in mediating targeting selectivity, the amide-linked conjugate pteroyl-NHCH(2)CH(2)OCH(2)CH(2)OCH(2)CH(2)NH-DTPA was prepared by a three-step procedure from Pteroic acid, 2,2'-(ethylenedioxy)-bis(ethylamine), and t-Bu-protected DTPA. This conjugate, 1-{2-[2-[(2-(biscarboxymethyl-amino)ethyl)-carboxymethyl-amino]ethyl]-carboxymethyl-amino}-acetylamino-3,6-dioxa-8-pteroylamino-octane (1), was employed for synthesis of the corresponding (111)In(III) radiopharmaceutical. Following intravenous administration to athymic mice, the (111)In complex of 1 was found to selectively localize in folate receptor-positive human KB tumor xenografts and to afford prolonged tumor retention of the (111)In radiolabel (5.4 +/- 0.8, 5.6 +/- 1.1, and 3.6 +/- 0.6% of the injected dose per gram of tumor at 1, 4, and 24 h, respectively). The observed tumor localization was effectively blocked by co-administration of folic acid with the (111)In-1 complex, consistent with a folate receptor-mediated targeting process. In control studies, tumor targeting with this Pteroic acid conjugate appears as effective as that seen using (111)In-DTPA-folate, a radiopharmaceutical that has progressed to clinical trials for detection of folate receptor-expressing gynecological tumors.
    Pteroic acid Description
    Source:
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2023 mL 16.0113 mL 32.0225 mL 64.0451 mL 80.0564 mL
    5 mM 0.6405 mL 3.2023 mL 6.4045 mL 12.809 mL 16.0113 mL
    10 mM 0.3202 mL 1.6011 mL 3.2023 mL 6.4045 mL 8.0056 mL
    50 mM 0.064 mL 0.3202 mL 0.6405 mL 1.2809 mL 1.6011 mL
    100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6405 mL 0.8006 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Can J Biochem Cell Biol . 1985 Jul;63(7):777-779.
    Activation of folypolyglutamate synthetase by pteroic acid[Pubmed: 3840051]
    The glutamylation of methotrexate catalyzed by beef liver folypolyglutamate synthetase (FPGS) is activated by addition of Pteroic acid. Pteroic acid causes greater stimulation of FPGS, including glutamylation of tetrahydrofolate, at neutral pH values (i.e., below the pH optimum of 8.4). We have attributed this activation to a conformational change of FPGS induced by Pteroic acid.
    J Med Chem . 1975 Aug;18(8):776-780.
    Synthesis and biological activity of 10-thia-10-deaza analogs of folic acid, pteroic acid, and related compounds[Pubmed: 808608]
    The 10-thia analogs of Pteroic acid, folic acid, their esters, and their 4-amino analogs were synthesized through a reaction sequence involving, as a key step, the condensation of 2-amino-3-cyano-5-chloromethylpyrazine with appropriately substituted thiols. The abilities of the products to inhibit the growth of methotrexate (MTX)-sensitive and MTX-resistant microorganisms were investigated as were their abilities to inhibit dihydrofolic acid reductase and thymidylic acid synthetase. Several compounds had high activity.
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