Pteroic acid | CAS:119-24-4 | Manufacturer ChemFaces

Pteroic acid

Citing Use of our Products

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: info@chemfaces.com

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal & Western Union

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

Celltrion Chemical Research Ins... (Korea)

Fraunhofer-Institut für Moleku... (Germany)

Periyar University (India)

Northeast Normal University Cha... (China)

University of Stirling (United Kingdom)

Nicolaus Copernicus Uniwersity (Poland)

Institute of Bioorganic Chemist... (Poland)

Mendel University in Brno (Czech Republic)

Cornell University (USA)

Worcester Polytechnic Institute (USA)

University of Otago (New Zealand)

More...

Package

Featured Products

More...

Neocryptotanshinone II

Catalog No: CFN92160
CAS No: 27468-20-8
Price: $463/5mg

Mulberroside A

Catalog No: CFN99586
CAS No: 102841-42-9
Price: $60/20mg

Acteoside

Catalog No: CFN97048
CAS No: 61276-17-3
Price: $60/20mg

Tanshindiol C

Catalog No: CFN92147
CAS No: 97465-71-9
Price: $418/5mg

Nodakenin

Catalog No: CFN90232
CAS No: 495-31-8
Price: $70/20mg

Enmein

Catalog No: CFN92435
CAS No: 3776-39-4
Price: $318/5mg

Glycitein

Catalog No: CFN99106
CAS No: 40957-83-3
Price: $70/20mg

Description:

Pteroic acid causes greater stimulation of FPGS, including glutamylation of tetrahydrofolate, at neutral pH values (i.e., below the pH optimum of 8.4).

In vivo:

J Am Chem Soc . 2005 May 25;127(20):7421-7426.

Targeting the tumor-associated folate receptor with an 111In-DTPA conjugate of pteroic acid[Pubmed: 15898791]

The cell membrane folate receptor is a potential molecular target for tumor-selective drug delivery. To probe structural requirements for folate receptor targeting with low molecular weight radiometal chelates, specifically the role of the amino acid fragment of folic acid (pteroylglutamic acid) in mediating targeting selectivity, the amide-linked conjugate pteroyl-NHCH(2)CH(2)OCH(2)CH(2)OCH(2)CH(2)NH-DTPA was prepared by a three-step procedure from Pteroic acid, 2,2'-(ethylenedioxy)-bis(ethylamine), and t-Bu-protected DTPA. This conjugate, 1-{2-[2-[(2-(biscarboxymethyl-amino)ethyl)-carboxymethyl-amino]ethyl]-carboxymethyl-amino}-acetylamino-3,6-dioxa-8-pteroylamino-octane (1), was employed for synthesis of the corresponding (111)In(III) radiopharmaceutical. Following intravenous administration to athymic mice, the (111)In complex of 1 was found to selectively localize in folate receptor-positive human KB tumor xenografts and to afford prolonged tumor retention of the (111)In radiolabel (5.4 +/- 0.8, 5.6 +/- 1.1, and 3.6 +/- 0.6% of the injected dose per gram of tumor at 1, 4, and 24 h, respectively). The observed tumor localization was effectively blocked by co-administration of folic acid with the (111)In-1 complex, consistent with a folate receptor-mediated targeting process. In control studies, tumor targeting with this Pteroic acid conjugate appears as effective as that seen using (111)In-DTPA-folate, a radiopharmaceutical that has progressed to clinical trials for detection of folate receptor-expressing gynecological tumors.

Pteroic acid Description

Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kinase Assay:

Can J Biochem Cell Biol . 1985 Jul;63(7):777-779.

Activation of folypolyglutamate synthetase by pteroic acid[Pubmed: 3840051]

The glutamylation of methotrexate catalyzed by beef liver folypolyglutamate synthetase (FPGS) is activated by addition of Pteroic acid. Pteroic acid causes greater stimulation of FPGS, including glutamylation of tetrahydrofolate, at neutral pH values (i.e., below the pH optimum of 8.4). We have attributed this activation to a conformational change of FPGS induced by Pteroic acid.

J Med Chem . 1975 Aug;18(8):776-780.

Synthesis and biological activity of 10-thia-10-deaza analogs of folic acid, pteroic acid, and related compounds[Pubmed: 808608]

The 10-thia analogs of Pteroic acid, folic acid, their esters, and their 4-amino analogs were synthesized through a reaction sequence involving, as a key step, the condensation of 2-amino-3-cyano-5-chloromethylpyrazine with appropriately substituted thiols. The abilities of the products to inhibit the growth of methotrexate (MTX)-sensitive and MTX-resistant microorganisms were investigated as were their abilities to inhibit dihydrofolic acid reductase and thymidylic acid synthetase. Several compounds had high activity.

CAS No.	119-24-4	Price
Catalog No.	CFN91587	Purity	>=98%
Molecular Weight	312.28	Type of Compound	Alkaloids
Formula	C₁₄H₁₂N₆O₃	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison

Product Name	Pteroic acid
CAS No.:	119-24-4
Catalog No.:	CFN91587
Molecular Formula:	C₁₄H₁₂N₆O₃
Molecular Weight:	312.28 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Download:	COA MSDS
Similar structural:	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2023 mL	16.0113 mL	32.0225 mL	64.0451 mL	80.0564 mL
5 mM	0.6405 mL	3.2023 mL	6.4045 mL	12.809 mL	16.0113 mL
10 mM	0.3202 mL	1.6011 mL	3.2023 mL	6.4045 mL	8.0056 mL
50 mM	0.064 mL	0.3202 mL	0.6405 mL	1.2809 mL	1.6011 mL
100 mM	0.032 mL	0.1601 mL	0.3202 mL	0.6405 mL	0.8006 mL

CFN70266	Lobeline sulfate	134-64-5	773.0	C₄₄H₅₆N₂O₈S
CFN96319	12-Demethylneocaesalpin F	1228964-10-0	470.6	C₂₇H₃₄O₇
CFN91896	23-epi-26-Deoxyactein	264624-38-6	660.83	C₃₇H₅₆O₁₀
CFN99853	Dimeric coniferyl acetate	184046-40-0	442.5	C₂₄H₂₆O₈