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Rubicordifolin
Rubicordifolin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Rubicordifolin
Price:
CAS No.: 849699-55-4
Catalog No.: CFN96852
Molecular Formula: C33H28O9
Molecular Weight: 568.57 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Rubia cordifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • National Research Council of Ca... (Canada)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Rubicordifolin exhibits potent cytotoxic and antitumor activities.
Targets: Topoisomerase
In vitro:
Korean Chemical Society National Meeting October. 2015.
Re2O7-Catalyzed Regioselective Synthesis of Naphtho[1,2-b]furan-3-carboxamides and Their Biological Evaluation[Reference: WebLink]

METHODS AND RESULTS:
Rubicordifolin was isolated as a natural product from Rubia cordifolia, and it exhibits potent cytotoxic and antitumor activities. Furomollugin has been isolated from several members of the Rubiaceae family and from Rubia cordifolia.
CONCLUSIONS:
The compound exhibits cytotoxic activity to human colon carcinoma cells (HT-29), strongly suppresses HBsAg secretion by human hepatoma Hep3B cells, and exhibits inhibitory activity against DNA topoisomerases I and II.
Rubicordifolin Description
Source: The herbs of Rubia cordifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7588 mL 8.794 mL 17.588 mL 35.176 mL 43.97 mL
5 mM 0.3518 mL 1.7588 mL 3.5176 mL 7.0352 mL 8.794 mL
10 mM 0.1759 mL 0.8794 mL 1.7588 mL 3.5176 mL 4.397 mL
50 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7035 mL 0.8794 mL
100 mM 0.0176 mL 0.0879 mL 0.1759 mL 0.3518 mL 0.4397 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Am Chem Soc. 2005 Mar 9;127(9):2870-1.
Biomimetic synthesis and structure elucidation of rubicordifolin, a cytotoxic natural product from Rubia cordifolia.[Pubmed: 15740120 ]
The biomimetic synthesis and full structural elucidation of Rubicordifolin, a cytotoxic natural product isolated from Rubia cordifolia, is described.
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CFN961192,3-Dihydroheveaflavone110382-42-8582.6C33H26O10
CFN954282,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene1608462-12-9332.4C20H28O4
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