Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    CAS No. 36417-86-4 Price $268 / 10mg
    Catalog No.CFN98494Purity>=98%
    Molecular Weight283.3 Type of CompoundPhenylpropanoids
    FormulaC17H17NO3Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email:
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $121.9 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Aveiro University (Portugal)
  • MTT Agrifood Research Finland (Finland)
  • National Hellenic Research Foun... (Greece)
  • Yale University (USA)
  • University of Sao Paulo (Brazil)
  • Hamdard University (India)
  • Sri Ramachandra University (India)
  • China Medical University (Taiwan)
  • Instituto de Investigaciones Ag... (Chile)
  • University of the Basque Country (Spain)
  • Seoul National University (Korea)
  • More...
  • Package
    Featured Products
    cis-Mulberroside A

    Catalog No: CFN95006
    CAS No: 166734-06-1
    Price: $418/10mg

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $188/20mg

    Catalog No: CFN92252
    CAS No: 510-22-5
    Price: $463/5mg

    Catalog No: CFN90240
    CAS No: 481-53-8
    Price: $30/20mg
    Platycoside M1

    Catalog No: CFN92267
    CAS No: 917482-67-8
    Price: $468/5mg
    Kaempferol 3-O-(6''-galloyl)-beta-...

    Catalog No: CFN92383
    CAS No: 56317-05-6
    Price: $533/5mg
    Isochlorogenic acid A

    Catalog No: CFN99118
    CAS No: 2450-53-5
    Price: $108/20mg


    Product Name N-p-trans-Coumaroyltyramine
    CAS No.: 36417-86-4
    Catalog No.: CFN98494
    Molecular Formula: C17H17NO3
    Molecular Weight: 283.3 g/mol
    Purity: >=98%
    Type of Compound: Phenylpropanoids
    Physical Desc.: Powder
    Targets: AChR
    Source: The herbs of Exochorda racemosa.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $268 / 10mg
    Inquire / Order:
    Technical Inquiries:
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • ACS Omega.2021, 6(36):23460-23474.
  • Biomed Pharmacother.2021, 137:111362.
  • Antioxidants (Basel).2021, 10(10):1638.
  • International Food Research Journal2018, 25(6):2560-2571
  • Antioxidants (Basel).2020, 9(11):1121.
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Phytomedicine.2019, 57:95-104
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
  • Anti-inflammatory Compound Library
  • Antioxidants Compound Library
  • Inhibitors Compound Library
  • Anti-platelet aggregation Compound Library
  • Alpha-glucosidase inhibitors Compound Library
  • Anti-trypanosoma Compound Library
  • Phenylpropanoids Compound Library
  • AChR Inhibitor Library
  • Biological Activity
    Description: N-p-trans-Coumaroyltyramine is an inhibitor on acetylcholinesterase (AChE), it inhibits AChE activity in a dose-dependent manner with IC50 value of 34.5 microg/mL (122 microM). It exhibits potent inhibition of cell proliferation, platelet aggregation, and shows antioxidant activity. N-trans-p-coumaroyltyramine shows activity against Trypanosoma brucei rhodesiense (IC50s ranging from 2.2 to 13.3 microM).
    Targets: AChR
    In vitro:
    Arch. Pharm. Res.,2003, 26(9):735-8.
    Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase.[Pubmed: 14560923]

    The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-trans-Coumaroyltyramine, as an inhibitor on AChE.
    This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of N-p-trans-Coumaroyltyramine was 34.5 microg/mL (122 microM).
    Nat Prod Commun. 2012 Jun;7(6):753-5.
    Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity.[Pubmed: 22816300]

    A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC50 = 3.7 microg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides, including N-trans-caffeoyltyramine (1), N-p-trans-Coumaroyltyramine (7), and N-trans-feruloyltyramine (8) as the main active constituents (IC50s ranging from 2.2 to 13.3 microM). Some structurally related, but less active compounds, such as cannabisin B (2), tyrosol (3), p-coumaric acid (4), ferulic acid (5), and N-cis-feruloyltyramine (6) were also identified, along with N-trans-3,4-dimethoxycinnamoyldopamine (9).
    Cytotoxicity of the active compounds in L6 cells was determined, and selectivity indices (SI) of 7.9 to 33.4 were calculated.
    N-p-trans-Coumaroyltyramine Description
    Source: The herbs of Exochorda racemosa.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to:

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds

    Catalog No: CFN95394
    CAS No: 104193-93-3
    Price: $318/5mg
    Theaflavanoside II

    Catalog No: CFN95380
    CAS No: 943785-09-9
    Price: $318/5mg

    Catalog No: CFN95055
    CAS No: 25694-72-8
    Price: $168/10mg

    Catalog No: CFN95053
    CAS No: 115746-69-5
    Price: $338/5mg
    Schisphenin E

    Catalog No: CFN95223
    CAS No: 1311376-52-9
    Price: $318/5mg

    Catalog No: CFN95365
    CAS No: 469899-55-6
    Price: $368/5mg
    New compound 6

    Catalog No: CFN95259
    CAS No: N/A
    Price: $413/5mg

    Catalog No: CFN95003
    CAS No: N/A
    Price: $358/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5298 mL 17.6491 mL 35.2983 mL 70.5965 mL 88.2457 mL
    5 mM 0.706 mL 3.5298 mL 7.0597 mL 14.1193 mL 17.6491 mL
    10 mM 0.353 mL 1.7649 mL 3.5298 mL 7.0597 mL 8.8246 mL
    50 mM 0.0706 mL 0.353 mL 0.706 mL 1.4119 mL 1.7649 mL
    100 mM 0.0353 mL 0.1765 mL 0.353 mL 0.706 mL 0.8825 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Kinase Assay:
    Bioscience Biotechnology & Biochemistry, 2014, 61(7):1138-1141.
    Isolation and Activity of N-p-Coumaroyltyramine, an α-Glucosidase Inhibitor in Welsh Onion (Allium fistulosum)[Reference: WebLink]
    A phenolic amide, N-p-trans-Coumaroyltyramine(1), was isolated as an α-glucosidase inhibitor from methanol extracts of Welsh onion (Allium fistulosum). The inhibitory activity of 1 against a yeast enzyme was as high as Ki 8.4 × 10617 m. From a structure-activity relationship study of 1 and its related compounds, the occurrence of α-glucosidase inhibitory activity required a p-coumaramide structure, with an amide hydrogen and alkyl or aralkyl substituent on the amide part.
    Structure Identification:
    Nat Prod Commun. 2011 Feb;6(2):227-9.
    Amides from the stem of Capsicum annuum.[Pubmed: 21425680]

    7'-(4'-hydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide (1), 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide (2), N-p-trans-Coumaroyltyramine (3), N-trans-caffeoyltyramine (4), beta-sitostenone (5), ferulic acid (6), hydroferulic acid (7), 5-hydroxy-3,4-dimethoxycinnamic acid (8), veratic acid (9), vanillic acid (10), isovanillic acid (11), syringic acid (12), (+)-syringaresinol (13), and pheophorbide a (14) were isolated from the stems of Capsicum annuum (Solanaceae). Among them, 1 is a new amide compound.
    The structures of these compounds were characterized and identified by spectral analyses.
    J. Phys. Chem. B, 2010, 114(8):3005-12.
    Interaction Studies of Coumaroyltyramine with Human Serum Albumin and Its Biological Importance[Pubmed: 20136105]
    N-trans-p-coumaroyltyramine (N-p-trans-Coumaroyltyramine, CT) isolated from Physalis minima is a phenolic substance exhibiting many pharmacological activities like potent inhibition of acetyl cholinesterase, cell proliferation, platelet aggregation, and also antioxidant activity.
    Here, we have studied the binding of CT with HSA at physiological pH 7.2 by using fluorescence, circular dichroism spectroscopy, mass spectrometry, and molecular docking methods. From the fluorescence emission studies, the number of binding sites and binding constant were calculated to be 2 and (4.5 +/- 0.01) x 10(5) M(-1), respectively. The free energy change was calculated as -7.6 kcal M(-1) at 25 degrees C, which indicates the hydrophobic interactions of CT with HSA and is in well agreement with the computational calculations and molecular docking studies. The changes in the secondary structure of HSA after its complexation with the ligand were studied with CD spectroscopy, which indicated that the protein became partially unfolded. Also, temperature did not affect the HSA-CT complexes.
    The binding of CT with HSA was detected as 2 molecules bound to HSA was determined using micro TOF-Q mass spectrometry. Further, molecular docking studies revealed that CT was binding at subdomain IIA with hydrophobic interactions and also by hydrogen-bond interactions between the hydroxyl (OH) group of carbon-16 and carbon-2 of CT and Arg222, Ala291, Val293, and Met298 of HSA, with hydrogen-bond distances of 2.488, 2.811, 2.678, and 2.586 A, respectively.
    cis-Mulberroside A

    Catalog No: CFN95006
    CAS No: 166734-06-1
    Price: $418/10mg

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $188/20mg

    Catalog No: CFN92252
    CAS No: 510-22-5
    Price: $463/5mg

    Catalog No: CFN90240
    CAS No: 481-53-8
    Price: $30/20mg
    Platycoside M1

    Catalog No: CFN92267
    CAS No: 917482-67-8
    Price: $468/5mg
    Kaempferol 3-O-(6''-galloyl)-beta-...

    Catalog No: CFN92383
    CAS No: 56317-05-6
    Price: $533/5mg
    Isochlorogenic acid A

    Catalog No: CFN99118
    CAS No: 2450-53-5
    Price: $108/20mg