S-Allyl-L-cysteine | CAS:21593-77-1 Manufacturer ChemFaces

S-Allyl-L-cysteine

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Description:

S-Allyl-L-cysteine exerts its neuroprotective effect by scavenging ONOO− and inhibiting the ERK signaling pathway activated during initial hypoxic/ischemic insults. S-Allyl-L-cysteine could protect against the neuronal cell death that is triggered by ER dysfunction in the hippocampus, and that it has no effect on neuronal cell death that is dependent upon the caspase-3 mediated pathway.

Targets:

ERK | Caspase | ROS | NO

In vitro:

Neuroence, 2003, 122(4):885-895.

S-allyl-l-cysteine selectively protects cultured rat hippocampal neurons from amyloid β-protein- and tunicamycin-induced neuronal death.[Reference: WebLink]

S-Allyl-L-cysteine (SAC), one of the organosulfur compounds found in aged garlic extract, has been shown to possess various biological effects including neurotrophic activity. In our previous experiments, we found that SAC could protect against amyloid β-protein (Aβ)- and tunicamycin-induced cell death in differentiated PC12 cells.
METHODS AND RESULTS:
In the study described here, we characterized the neuronal death induced by Aβ, 4-hydroxynonenal (HNE), tunicamycin, and trophic factor deprivation, and investigated whether and how SAC could prevent this in cultured rat hippocampal neurons. Treatment with SAC protected these cells against Aβ- and tunicamycin-induced neuronal death, which is mediated predominantly through caspase-12-dependent pathway in a concentration-dependent manner. In contrast, it afforded no protection against HNE- and trophic factor-deprivation-induced cell death, which has been shown to be mediated by caspase-3-dependent pathway. SAC also attenuated the Aβ-induced increase of intracellular reactive oxygen species in hippocampal neurons. SAC had no effect on Aβ-induced cell death in cultured cerebellar granule neurons, which was prevented by a caspase-3 inhibitor.
CONCLUSIONS:
These results suggest that SAC could protect against the neuronal cell death that is triggered by ER dysfunction in the hippocampus, and that it has no effect on neuronal cell death that is dependent upon the caspase-3 mediated pathway.

S-Allyl-L-cysteine Description

Source:	From garlic
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kinase Assay:

Free radical research, 2006, 40(8):827-35.

S-Allyl-l-cysteine attenuates cerebral ischemic injury by scavenging peroxynitrite and inhibiting the activity of extracellular signal-regulated kinase.[Reference: WebLink]

S-Allyl-L-cysteine (SAC) has been shown to reduce ischemic injury due to its antioxidant activity. However, the antioxidant property of SAC has been controversial. The present study investigated the neuroprotective mechanism of SAC in cerebral ischemic insults.
METHODS AND RESULTS:
SAC decreased the size of infarction after transient or global ischemic insults. While it did not alter the N-methyl-d-aspartate excitotoxicity, SAC significantly scavenged the endogenously or exogenously produced ONOO− and reduced ONOO− cytotoxicity. In contrast, SAC has much lower scavenging activity against H2O2, or NO. Further, SAC inhibited the activity of extracellular signal-regulated kinase (ERK) increased in cultured neurons exposed to oxygen-glucose deprivation or in rat brain tissue after transient middle cerebral artery occlusion. The neuroprotective effect of SAC was mimicked by the ERK inhibitor U0125.
CONCLUSIONS:
The present results indicate that SAC exert its neuroprotective effect by scavenging ONOO− and inhibiting the ERK signaling pathway activated during initial hypoxic/ischemic insults.

CAS No.	21593-77-1	Price	$70 / 20mg
Catalog No.	CFN70240	Purity	>=98%
Molecular Weight	161.2	Type of Compound	Alkaloids
Formula	C₆H₁₁NO₂S	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library ROS Inhibitor Library NO Inhibitor Library ERK Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.2035 mL	31.0174 mL	62.0347 mL	124.0695 mL	155.0868 mL
5 mM	1.2407 mL	6.2035 mL	12.4069 mL	24.8139 mL	31.0174 mL
10 mM	0.6203 mL	3.1017 mL	6.2035 mL	12.4069 mL	15.5087 mL
50 mM	0.1241 mL	0.6203 mL	1.2407 mL	2.4814 mL	3.1017 mL
100 mM	0.062 mL	0.3102 mL	0.6203 mL	1.2407 mL	1.5509 mL

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