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3. Inhibitors
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
J Pharm Biomed Anal.2018, 151:32-41Molecules. 2013, 18(7):7376-88Pharmaceuticals (Basel)....2021...J Pharmaceut Biomed2020, 182:113110Plants (Basel).2020, 9(11):1422.LWT2021, 150:112021.Molecules.2020, 25(15):3353.ARPN Journal of Eng.& Applied Sci...2016...
PLoS One.2018, 13(3):e0193386Food Res Int.2017, 96:40-45J Med Food.2021, 24(2):151-160.Dicle Tip Dergisi2020, 47(2),423-430.Int J Med Sci.2020, 17(5):626-631Biochem Biophys Res Commun....2018...Horticulture Research2022, uhac276.Arch Biochem Biophys.2020, 687:108363.
J Agric Food Chem.2015, 63(44):9869-78Pharmacol Rep.2019, 71(2):289-298J Microbiol Immunol Infect....2021...Drug Dev Res.2020, doi: 10.1002Appl. Sci. 2021, 11(22),10569Oxid Med Cell Longev2019, 9056845:13Biomed Pharmacother.2021, 139:111585.
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Our products had been exported to the following research institutions and universities, And still growing.
VIB Department of Plant Systems... (Belgium)Universiti Malaysia Pahang (Malaysia)Chungnam National University (Korea)University of Canterbury (New Zealand)
Colorado State University (USA)University of Illinois (USA)Instytut Nawozów Sztucznych w ... (Poland)Stanford University (USA)
Institute of Chinese Materia Me... (China)University of Parma (Italy)University of the Basque Country (Spain)
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Scutebata B
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Semyung University2017, 149407Pharmaceuticals (Basel).2022, 15(5):591. Appl. Sci. 2021, 11(10),4666.J Nat Med.2022, 76(1):59-67. Evid Based Complement Alternat Med.2017, 2017:1401279Enzyme Microb Technol.2022, 153:109941. Nat Plants.2016, 3:16205Industrial Crops and Products2022, 188:115596.Processes2021, 9(5),831.Nat Commun.2019, 10(1):5169
Related Screening Libraries
Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
Description: |
Scutebata B inhibited NO production efficiently with IC50 values of lower than 50 μM. |
Targets: |
NO |
In vitro: |
Chemistry & Biodiversity, 2017, 14(11). | Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells.[Reference: WebLink] | METHODS AND RESULTS: The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), Scutebata B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 μM. Particularly, compound 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 μM, respectively.
CONCLUSIONS:
This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation. |
|
Scutebata B Description
Source: |
The herbs of Scutellaria barbata D.Don |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
1.578 mL |
7.8902 mL |
15.7803 mL |
31.5607 mL |
39.4508 mL |
5 mM |
0.3156 mL |
1.578 mL |
3.1561 mL |
6.3121 mL |
7.8902 mL |
10 mM |
0.1578 mL |
0.789 mL |
1.578 mL |
3.1561 mL |
3.9451 mL |
50 mM |
0.0316 mL |
0.1578 mL |
0.3156 mL |
0.6312 mL |
0.789 mL |
100 mM |
0.0158 mL |
0.0789 mL |
0.1578 mL |
0.3156 mL |
0.3945 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Structure Identification: |
Journal of Natural Products, 2010, 73(2):233-236. | Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.[Reference: WebLink] | METHODS AND RESULTS:
Seven new neoclerodane diterpenoids, scutebata A, Scutebata B, scutebata C, scutebata D, scutebata E, scutebata F, scutebata G
(1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1.
CONCLUSIONS:
Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM. |
|
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