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Scutebata B
Information
CAS No. 1207181-58-5 Price
Catalog No.CFN99323Purity>=98%
Molecular Weight633.7 Type of CompoundDiterpenoids
FormulaC35H39NO10Physical DescriptionPowder
Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
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    Scutebata B

    Scutebata B
    Product Name Scutebata B
    CAS No.: 1207181-58-5
    Catalog No.: CFN99323
    Molecular Formula: C35H39NO10
    Molecular Weight: 633.7 g/mol
    Purity: >=98%
    Type of Compound: Diterpenoids
    Physical Desc.: Powder
    Targets: NO
    Source: The herbs of Scutellaria barbata D.Don
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Download: COA    MSDS    SDF    Manual
    Similar structural: Comparison (Web)  (SDF)
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    product package
  • Semyung University2017, 149407
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • Appl. Sci. 2021, 11(10),4666.
  • J Nat Med.2022, 76(1):59-67.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Scutebata B inhibited NO production efficiently with IC50 values of lower than 50 μM.
    Targets: NO
    In vitro:
    Chemistry & Biodiversity, 2017, 14(11).
    Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells.[Reference: WebLink]

    METHODS AND RESULTS:
    The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), Scutebata B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 μM. Particularly, compound 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 μM, respectively.
    CONCLUSIONS:
    This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.
    Scutebata B Description
    Source: The herbs of Scutellaria barbata D.Don
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.578 mL 7.8902 mL 15.7803 mL 31.5607 mL 39.4508 mL
    5 mM 0.3156 mL 1.578 mL 3.1561 mL 6.3121 mL 7.8902 mL
    10 mM 0.1578 mL 0.789 mL 1.578 mL 3.1561 mL 3.9451 mL
    50 mM 0.0316 mL 0.1578 mL 0.3156 mL 0.6312 mL 0.789 mL
    100 mM 0.0158 mL 0.0789 mL 0.1578 mL 0.3156 mL 0.3945 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Journal of Natural Products, 2010, 73(2):233-236.
    Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.[Reference: WebLink]

    METHODS AND RESULTS:
    Seven new neoclerodane diterpenoids, scutebata A, Scutebata B, scutebata C, scutebata D, scutebata E, scutebata F, scutebata G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1.
    CONCLUSIONS:
    Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.
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