Scutebata B | CAS:1207181-58-5 | Manufacturer ChemFaces

Scutebata B

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Description:

Scutebata B inhibited NO production efficiently with IC50 values of lower than 50 μM.

Targets:

In vitro:

Chemistry & Biodiversity, 2017, 14(11).

Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells.[Reference: WebLink]

METHODS AND RESULTS:
The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), Scutebata B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 μM. Particularly, compound 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 μM, respectively.
CONCLUSIONS:
This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.

Scutebata B Description

Source:	The herbs of Scutellaria barbata D.Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Journal of Natural Products, 2010, 73(2):233-236.

Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.[Reference: WebLink]

METHODS AND RESULTS:
Seven new neoclerodane diterpenoids, scutebata A, Scutebata B, scutebata C, scutebata D, scutebata E, scutebata F, scutebata G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1.
CONCLUSIONS:
Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.

CAS No.	1207181-58-5	Price
Catalog No.	CFN99323	Purity	>=98%
Molecular Weight	633.7	Type of Compound	Diterpenoids
Formula	C₃₅H₃₉NO₁₀	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	Scutebata B
CAS No.:	1207181-58-5
Catalog No.:	CFN99323
Molecular Formula:	C₃₅H₃₉NO₁₀
Molecular Weight:	633.7 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Targets:	NO
Source:	The herbs of Scutellaria barbata D.Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.578 mL	7.8902 mL	15.7803 mL	31.5607 mL	39.4508 mL
5 mM	0.3156 mL	1.578 mL	3.1561 mL	6.3121 mL	7.8902 mL
10 mM	0.1578 mL	0.789 mL	1.578 mL	3.1561 mL	3.9451 mL
50 mM	0.0316 mL	0.1578 mL	0.3156 mL	0.6312 mL	0.789 mL
100 mM	0.0158 mL	0.0789 mL	0.1578 mL	0.3156 mL	0.3945 mL

CFN97965	16-Hydroxy-2-oxocleroda-3,13-dien-15,16-olide	165459-53-0	332.4	C₂₀H₂₈O₄
CFN89211	(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al	935293-70-2	332.44	C₂₀H₂₈O₄
CFN97990	6alpha,16,18-Trihydroxycleroda-3,13-dien-15,16-olide	1017233-48-5	350.5	C₂₀H₃₀O₅
CFN89104	Dodovislactone B	1616683-55-6	362.46	C₂₁H₃₀O₅
CFN96683	Scutebarbatine Z	1312716-28-1	439.55	C₂₆H₃₃NO₅
CFN96686	Scutebarbatine Y	1312716-27-0	557.64	C₃₃H₃₅NO₇
CFN99028	6-O-Nicotinoylbarbatin C	1015776-92-7	453.5	C₂₆H₃₁NO₆
CFN97471	Scutebarbatine B	905929-95-5	557.6	C₃₃H₃₅NO₇
CFN99832	Scutebarbatine A	176520-13-1	558.6	C₃₂H₃₄N₂O₇
CFN99324	Scutebata C	1207181-59-6	529.6	C₂₈H₃₅NO₉