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    Natural Products
    Serpentinine
    Information
    CAS No. 36519-42-3 Price
    Catalog No.CFN98499Purity>=98%
    Molecular Weight684.8 Type of CompoundAlkaloids
    FormulaC42H44N4O5Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Serpentinine

    Serpentinine
    Product Name Serpentinine
    CAS No.: 36519-42-3
    Catalog No.: CFN98499
    Molecular Formula: C42H44N4O5
    Molecular Weight: 684.8 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The roots of Rauvolfia verticillata (Lour.) Baill.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Bio-protocol2018, 9(14):e3301
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  • Comput Biol Chem.2019, 83:107096
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  • Oncotarget.2015, 6(31):30831-49
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antihypertensive Compound Library
  • Alkaloids Compound Library
  • Biological Activity
    Description: Serpentinine may have antihypertensive effect.
    In vitro:
    Current Hypertension Reviews,2010, 6(3):190-8.
    Resurgence of Herbal Antihypertensives in Management of Hypertension.[Reference: WebLink]
    Hypertension is one of the major cardiovascular problems and causes a number of vascular disorders. Until the 1940s majority of the diseases were treated by traditional drugs obtained from plants/herbs only. Even the first potent herbal antihypertensive was obtained from root of Rauwolfia serpentina, a famous Ayurvedic plant but soon the modern antihypertensives took the center-stage because of their precise, defined and fast action. However, due to their growing adverse effects, interest in the use of these drugs also gradually started waning. This has lead to the resurgence of marked awareness about traditional medicines and a considerable renewed global interest in the plant based drugs. Much emphasis is now being given to validate the extract/fraction as well as single molecules obtained from plant resources based on their traditional claims.
    METHODS AND RESULTS:
    In this review, we have laid emphasis on the mechanistic aspect of antihypertensive effect of some medicinal plants and their therapeutic use. We have further tried to shed light on the attempts being made for the validation and documentation of traditional plants and herbs for their future development as potential therapy in hypertension. What's already known? • The herbal medications had been used since long to treat various cardiovascular disorders including high blood pressure before the arrival of modern therapy. • Global interest has now been renewed in herbal medicines but need authentication and validation in support of their therapeutic value. What this article may add? • This review emphasizes the mechanistic aspect of herbal medicines, their therapeutic values in clinical situation as well as present measures and recent approaches to validate and document their antihypertensive efficacies.
    Serpentinine Description
    Source: The roots of Rauvolfia verticillata (Lour.) Baill.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4603 mL 7.3014 mL 14.6028 mL 29.2056 mL 36.507 mL
    5 mM 0.2921 mL 1.4603 mL 2.9206 mL 5.8411 mL 7.3014 mL
    10 mM 0.146 mL 0.7301 mL 1.4603 mL 2.9206 mL 3.6507 mL
    50 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5841 mL 0.7301 mL
    100 mM 0.0146 mL 0.073 mL 0.146 mL 0.2921 mL 0.3651 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J. Chem. Soc., Chem. Commun., 1972, 871-871
    X-Ray crystallographic determination of the structure of the alkaloid serpentinine[Reference: WebLink]

    METHODS AND RESULTS:
    The structure of the alkaloid Serpentinine, C42H44N4O5, from Rauwolfia species, has been elucidated by X-ray crystallographic studies of its dihydrobromide dihydrate.
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