| Description: |
Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI of 0.2 and 0.3, respectively. Shoreic acid shows activity against Mycobacterium tuberculosis. Shoreic acid also has antiviral activity against Herpes simplex virus types I and II in vitro. |
| In vitro: |
| J Nat Prod. 1987 Jul-Aug;50(4):706-13. | | In vitro antiviral activity of dammar resin triterpenoids.[Pubmed: 2828553] |
METHODS AND RESULTS:
Nine triterpenes with antiviral activity against Herpes simplex virus types I and II in vitro were isolated from dammar resin.
Each compound caused a significant reduction in viral cytopathic effect when Vero cells were exposed continuously to 1-10 micrograms/ml of compound for 48 h after viral challenge.
CONCLUSIONS:
The triterpenes were identified as dammaradienol [1], dammarenediol-II [2], hydroxydammarenone-I [3], ursonic acid [5], hydroxyhopanone [11], dammarenolic acid [15], Shoreic acid [16], eichlerianic acid [17], and a novel compound, hydroxyoleanonic lactone [7], on the basis of their chromatographic, spectroscopic, and physical properties. | | Kimika, 2010, 23(1):50-4. | | An antimicrobial triterpene from Shorea guiso.[Reference: WebLink] |
METHODS AND RESULTS:
The dichloromethane extract of the air-dried leaves of Shorea guiso, a critically endangered Philippine tree, afforded Shoreic acid (1) by column chromatography. The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy.
CONCLUSIONS:
Compound 1 exhibited antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively. It also showed antifungal activity against C. albicans and T. mentagrophytes with AI of 0.2 and 0.3, respectively. It was inactive against A. niger. |
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