ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $268 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Ethnopharmacol.2016, 194:219-227J Basic Clin Physiol Pharmacol....2016...Org Biomol Chem.2017, 15(31):6483-6492Evid Based Complement Alternat Me...2017...Mol Cell.2017, 68(4):673-685Korean J of Medicinal Crop Scienc...2018...Journal of Physiology & Pathology...2018...Pharmacol Rep.2018, 70(6):1195-1201
Saf Health Work.2019, 10(2):196-204APMIS.2019, 127(10):688-695Nutr Res Pract2019, 13:e45ACS Chem Biol.2019, 14(5):873-881Molecules.2019, 24(7):E1290Journal of Apiculture...2019...Int J Mol Med.2019, 43(6):2516-2522Korean Journal of Pharmacognosy...2019...
J of Applied Pharmaceutical Scien...2020...Saudi Pharm J2020, 10.1016Oncol Lett.2020, 20(4):122.iScience.2020, 23(2):100849.Eur Rev Med Pharmacol Sci....2020...Horticulture Research2020, 7:111. J Ethnopharmacol.2021, 267:113615.
Our products had been exported to the following research institutions and universities, And still growing.
Shanghai Institute of Organic C... (China)Texas A&M University (USA)Amity University (India)Northeast Normal University Cha... (China)
University of Vigo (Spain)Rio de Janeiro State University (Brazil)University of Virginia (USA)University of Wuerzburg (Germany)
Universidad de Antioquia (Colombia)Helmholtz Zentrum München (Germany)Universite Libre de Bruxelles (Belgium)
Related Screening Libraries
||(-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis, may be a potential chemotherapeutic agent for the treatment of cancer. |
||Cdk | p21 | Bcl-2/Bax | Caspase | PARP | P450 (e.g. CYP17)|
||The rhizomes of Polygonatum kingianum
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Int Immunopharmacol. 2008 Jul;8(7):967-73. |
|(-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]|
We examined the effect of (-)-Syringaresinol, a furofuran-type lignan isolated from Daphne genkwa, on cell cycle regulation in HL-60 human promyelocytic leukemia cells in vitro.
METHODS AND RESULTS:
(-)-Syringaresinol decreased the viability of HL-60 cells by inducing G(1) arrest followed by apoptosis in a dose- and time-dependent manner. The G(0)/G(1) phase of the cell cycle is regulated by cyclin-dependent kinases (Cdk), cyclins and cyclin-dependent kinase inhibitors (Cdki). We show by western blot analysis, that the (-)-Syringaresinol-induced G(1) arrest was mediated through the increased expression of Cdki proteins (p21(cip1/waf1) and p27(kip1)) with a simultaneous decrease in cdk2, cdk4, cdk6, cyclin D(1), cyclin D(2), and cyclin E expression. The induction of apoptosis after treatment with (-)-Syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
These findings suggest that (-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.