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    Natural Products
    Skimmin
    Skimmin
    Information
    CAS No. 93-39-0 Price $238 / 20mg
    Catalog No.CFN97505Purity>=98%
    Molecular Weight324.3 Type of CompoundCoumarins
    FormulaC15H16O8Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $85.5 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Skimmin

    Skimmin
    Product Name Skimmin
    CAS No.: 93-39-0
    Catalog No.: CFN97505
    Molecular Formula: C15H16O8
    Molecular Weight: 324.3 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Targets: TGF-尾/Smad | IL Receptor
    Source: The herbs of Hydrangea paniculata.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $238 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
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    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Skimmin has anti-inflammatory, and anti-cancer activities, it can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis; it also can suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway.
    Targets: TGF-β/Smad | IL Receptor
    In vitro:
    Bioimpacts. 2014;4(4):191-8.
    Geno/cytotoxicty and Apoptotic Properties of Phenolic Compounds from the Seeds of Dorema Glabrum Fisch. C.A.[Pubmed: 25671175 ]
    Dorema glabrum (Apiaceae) is a rare and monocarpic species distributed in Transcaucasia and North West of Iran. We aimed to explore anti-cancer potency of bioactive compounds from the seeds of Dorma glabrum.
    METHODS AND RESULTS:
    Methanol extract was subjected to phytochemical investigation using normal phase Sep-pak and reversed-phase HPLC, and cytotoxic effect of isolated compounds on CAOV-4 cell line was evaluated. Furthermore, Annexin V/PI staining and comet assay were used to study genotoxicity of compounds. Diglucosyl caffeoyl ester (1), Glucopyranosylcaffeic acid (2) and Skimmin (3), were identified. MTT cytotoxicity assay showed growth inhibition of CAOV-4 cells due to treatment with compunds (1), (2) and (3) with an IC50 of 99.7, 87.3 and 70.03 μg/ml at 48 h, respectively. Annexin V-FITC/PI staining showed occurrence of early/late apoptosis in the (1)-treated cells, while (2)-and (3)-treated cells necrosis/late apoptosis was dominant event. Single/double strands DNA breakages were observed by comet assay in all treatments.
    CONCLUSIONS:
    This work provides sufficient information about anti-cancer properties of the diglucosyl caffeoyl ester from the seeds of D. glabrum.
    In vivo:
    Eur J Pharmacol. 2012 Oct 5;692(1-3):78-83.
    Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats.[Pubmed: 22664227]
    Skimmin, a major active ingredient from Hydrangea paniculata, was considered to have the possible preventive effect on the progression of diabetic nephropathy based on the traditional Chinese medicine. The present study aimed to assess this preventive activity in a rat model of diabetic nephropathy.
    METHODS AND RESULTS:
    Adult wistar rats were induced to develop diabetic nephropathy through injection of streptozotocin (60mg/kg). Animals were treated orally with saline, Skimmin at 7.5, 15 and 30mg/kg, and losartan (10mg/kg) daily for 17 weeks. At 7 and 17 weeks, blood and urine samples were collected for biochemical examination; at the end of 17 weeks, all the kidney tissues were collected for the histological examination. Enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) were used to analyze the expression of transforming growth factor-beta 1(TGF-β1) and its receptors in blood and kidney tissues respectively. Our results suggested that Skimmin could decrease the Scr and glucose level in blood of diabetic rats significantly (P<0.01), and increase the creatinine clearance (P<0.01), similar changes were also observed in the losartan-treated rats. In histological examination, Skimmin-treated rats showed a significant decrease in glomcrulus segmented sclerosis and incidence of tubule vacuolar degeneration (P<0.01), similar but less significant beneficial effects were observed for losartan treatment. By ELISA, western blotting and RT-PCR, we found Skimmin could down-regulate the TGF-β1 and TGF-β Receptor I expression both at protein and mRNA levels.
    CONCLUSIONS:
    This study suggests that the Skimmin can suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway.
    Skimmin Description
    Source: The herbs of Hydrangea paniculata.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0836 mL 15.4178 mL 30.8356 mL 61.6713 mL 77.0891 mL
    5 mM 0.6167 mL 3.0836 mL 6.1671 mL 12.3343 mL 15.4178 mL
    10 mM 0.3084 mL 1.5418 mL 3.0836 mL 6.1671 mL 7.7089 mL
    50 mM 0.0617 mL 0.3084 mL 0.6167 mL 1.2334 mL 1.5418 mL
    100 mM 0.0308 mL 0.1542 mL 0.3084 mL 0.6167 mL 0.7709 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Evid Based Complement Alternat Med. 2013;2013:819296.
    Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition.[Pubmed: 23990847]
    Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent.
    METHODS AND RESULTS:
    In the current study, we attempted to investigate its renoprotective activity and underlying mechanisms in a rat model of membranous glomerulonephritis induced by cationic bovine serum albumin (c-BSA). Sprague-Dawley (SD) rats were divided into five groups, including normal control, model control, Mycophenolate Mofetil-treated group, and two Skimming-treated groups (15 mg/kg and 30 mg/kg). Our research showed that treatment with Skimmin significantly reduced the levels of blood urea nitrogen (BUN), urinary albumin excretion (UAE), and serum creatinine (Scr) as compared with model control after experimental induction of membranous glomerulonephritis (P < 0.01). Moreover, glomerular hypercellularity, tubulointerstitial injury, and glomerular deposition of IgG were less intense after Skimmin treatment. By immunochemistry analysis, we demonstrated that Skimmin could significantly inhibit interleukin-1 β (IL1 β ) and IL-6 expression (P < 0.05), reduce the loss of nephrin and podocin, and suppress the infiltration of renal interstitium by CD3-positive T cell and CD20-positive B cell.
    CONCLUSIONS:
    These results suggest that treatment with Skimmin can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis.
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