Soyasaponin IV | CAS:108906-97-4 | Manufacturer ChemFaces

Soyasaponin IV

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Soyasaponin IV has hepatoprotective activity.It also has antimutagenic activity in mammalian cells.

In vitro:

Planta Med., 1998, 64(3):233-6.

Structure-hepatoprotective relationships study of soyasaponins I-IV having soyasapogenol B as aglycone.[Pubmed: 9581521 ]

As a part of our study on the leguminous plants, we investigated the constituents of the aerial parts of Glycine soya.
METHODS AND RESULTS:
We isolated and identified four known saponins, soyasaponins I, II, III, and IV which have the same aglycone, soyasapogenol B. As a part of our studies concerning hepatoprotective drugs, we also examined the hepatoprotective actions of these saponins towards immunologically induced liver injury on primary cultured rat hepatocytes. The action of soyasaponin II was almost comparable with that of soyasaponin I, whereas those of soyasaponin III and Soyasaponin IV were more effective than soyasaponins I and II. This means that the disaccharide group shows greater action than the trisaccharide group. Furthermore, the saponin having a hexosyl unit shows a slightly greater action than that of the pentosyl unit in each disaccharide group or trisaccharide group.
CONCLUSIONS:
Structure-activity relationships suggest that the sugar moiety linked at C-3 may play an important role in hepatoprotective actions of soybean saponins.

Soyasaponin IV Description

Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Mut. Res., 2000, 448(1):11-22.

Characterization and antimutagenic activity of soybean saponins.[Pubmed: 10751618]

An extract was prepared from a commercial soybean-processing by-product (soybean molasses) and was fractionated into purified chemical components. In previous work, this extract (phytochemical concentrate, PCC) repressed induced genomic DNA damage, whole cell clastogenicity and point mutation in cultured mammalian cells.
METHODS AND RESULTS:
In the current study, a chemical fraction was isolated from PCC using preparative high-performance liquid chromatography (HPLC). This fraction, PCC100, repressed 2-acetoxyacetylaminofluorene (2AAAF)-induced DNA damage in Chinese hamster ovary (CHO) cells as measured by single cell gel electrophoresis (alkaline Comet assay). Using liquid chromatography-electrospray ionization-mass spectroscopy and 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, PCC100 was shown to consist of a mixture of group B soyasaponins and 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) soyasaponins. These include soyasaponins I, soyasaponin II, soyasaponin III, Soyasaponin IV, soyasaponin V, soyasaponin Be, soyasaponin betag, soyasaponin betaa, soyasaponin gammag and soyasaponin gammaa.
CONCLUSIONS:
Purified soyasapogenol B aglycone prepared from fraction PCC100 demonstrated significant antigenotoxic activity against 2AAAF. To our knowledge, these data demonstrate for the first time the antimutagenic activity of soybean saponins in mammalian cells.

Product Name	Soyasaponin IV
Price:
CAS No.:	108906-97-4
Catalog No.:	CFN93251
Molecular Formula:	C₄₁H₆₆O₁₃
Molecular Weight:	767.0 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatoprotective Compound Library Anti-mutagenic Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3038 mL	6.5189 mL	13.0378 mL	26.0756 mL	32.5945 mL
5 mM	0.2608 mL	1.3038 mL	2.6076 mL	5.2151 mL	6.5189 mL
10 mM	0.1304 mL	0.6519 mL	1.3038 mL	2.6076 mL	3.2595 mL
50 mM	0.0261 mL	0.1304 mL	0.2608 mL	0.5215 mL	0.6519 mL
100 mM	0.013 mL	0.0652 mL	0.1304 mL	0.2608 mL	0.3259 mL

CFN90455	Soyasaponin Aa	117230-33-8	1365.46	C₆₄H₁₀₀O₃₁
CFN90773	Soyasaponin Ab	118194-13-1	1437.6	C₆₇H₁₀₄O₃₃
CFN90774	Soyasaponin Ac	133882-74-3	1421.6	C₆₇H₁₀₄O₃₂
CFN80325	Pedunsaponin C	272120-53-3	795.0	C₄₂H₆₆O₁₄
CFN80329	Pedunsaponin A	250613-27-5	811.0	C₄₂H₆₆O₁₅
CFN90777	Soyasaponin Be methyl Ester	N/A	955.2	C₄₉H₇₈O₁₈
CFN90775	Soyasaponin Bd	135272-91-2	957.1	C₄₈H₇₆O₁₉
CFN93251	Soyasaponin IV	108906-97-4	767.0	C₄₁H₆₆O₁₃
CFN91596	Soyasaponin III	55304-02-4	796.99	C₄₂H₆₈O₁₄
CFN93159	Soyasaponin II	55319-36-3	913.1	C₄₇H₇₆O₁₇