Streptozotocin | CAS:18883-66-4 | Manufacturer ChemFaces

Streptozotocin

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Description:

Streptozotocin, which produces diabetes mellitus in experimental animals, has been reported to reduce the level of NAD in pancreatic isletsand to inhibit islet synthesis of proinsulin.Streptozotocin can induce pancreatic insulitis, which is a new model of diabetes mellitus.

Targets:

PARP

In vivo:

Nature, 1981, 294(5838):284-6.

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.[Pubmed: 6272129]

Streptozotocin, which produces diabetes mellitus in experimental animals, has been reported to reduce the level of NAD in pancreatic isletsand to inhibit islet synthesis of proinsulin. The decrease in NAD is due to increased NAD degradation mediated by islet nuclear poly(ADP-ribose) synthetase. Evidence suggests that poly(ADP-ribose) synthetase is activated when DNA is fragmented.
METHODS AND RESULTS:
Here we describe that both Streptozotocin and alloxan, which also produces experimental diabetes mellitus, cause DNA strand breaks which stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.

Science, 1976, 193(4251):415-7.

Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus.[Pubmed: 180605]

METHODS AND RESULTS:
Multiple small injections of Streptozotocin in mice produce pancreatic insulitis, with progression to nearly complete beta cell destruction and diabetes mellitus. The timing and appearance of the inflammatory islet lesions suggest but do not prove that Streptozotocin acts by initiating a cell-mediated immune reaction.
CONCLUSIONS:
Ultrastructural evidence of abundant type C viruses within beta cells of treated mice suggests that Streptozotocin may activate murine leukemia virus in vivo in susceptible hosts.

Streptozotocin Description

Source:	From Stre.achromogenes Uar.128
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Streptozotocin
Price:
CAS No.:	18883-66-4
Catalog No.:	CFN93213
Molecular Formula:	C₈H₁₅N₃O₇
Molecular Weight:	265.22 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	From Stre.achromogenes Uar.128
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diabetic inducers Compound Library Miscellaneous Compound Library PARP Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7705 mL	18.8523 mL	37.7045 mL	75.4091 mL	94.2614 mL
5 mM	0.7541 mL	3.7705 mL	7.5409 mL	15.0818 mL	18.8523 mL
10 mM	0.377 mL	1.8852 mL	3.7705 mL	7.5409 mL	9.4261 mL
50 mM	0.0754 mL	0.377 mL	0.7541 mL	1.5082 mL	1.8852 mL
100 mM	0.0377 mL	0.1885 mL	0.377 mL	0.7541 mL	0.9426 mL

CFN92944	Thermopsidine	492-02-4	406.52	C₂₄H₃₀N₄O₂
CFN96780	Lumichrome	1086-80-2	242.23	C₁₂H₁₀N₄O₂
CFN99992	Indigo	482-89-3	262.26	C₁₆H₁₀N₂O₂
CFN90007	5-Aza-2'-deoxycytidine	2353-33-5	228.21	C₈H₁₂N₄O₄
CFN92490	Cytidine	65-46-3	243.2	C₉H₁₃N₃O₅
CFN91543	2'-Deoxycytidine	951-77-9	227.2	C₉H₁₃N₃O₄
CFN90029	Histamine	51-45-6	111.15	C₅H₉N₃
CFN93091	L-carnosine	305-84-0	226.23	C₉H₁₄N₄O₃
CFN90094	2'',3''-Di-O-acetyl-5''-deoxy-5-fuluro-D-cytidine	161599-46-8	329.28	C₁₃H₁₆FN₃O₆
CFN90095	5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate	162204-20-8	443.42	C₁₉H₂₆FN₃O₈