ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $239.2 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Biol Chem.2014, 289(3):1723-31Food and Bioprocess Technology...2017...J. of The Korean Society of Food ...2017...J Chromatogr A.2017, 1518:46-58J Ethnopharmacol.2017, 206:73-77Molecules.2017, 22(3)Srinagarind Medical Journal2017, 32(1)Molecules.2018, 23(12):E3103
Chem Biol Interact.2018, 290:44-51Mol Cells.2018, 41(8):771-780Curr Eye Res.2018, 43(1):27-34J Nat Sc Biol Med2019, 10(2):149-156Phytother Res.2019, 10.1002Front Pharmacol.2019, 10:1355International J of Green Pharmacy...2019...J of Physics Conference Series...2019...
Cell Physiol Biochem....2019...Antioxidants (Basel).2019, 8(8):E307Metabolites.2020, 10(11):440.Front Pharmacol.2020, 11:251.Front Pharmacol.2020, 11:683.Chinese Journal of Hospital Pharm...2020...Naunyn Schmiedebergs Arch Pharmac...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Institute of Tropical Disease U... (Indonesia)Rio de Janeiro State University (Brazil)University of Helsinki (Finland)University Medical Center Mainz (Germany)
Julius Kühn-Institut (Germany)Gyeongsang National University (Korea)The University of Newcastle (Australia)Srinakharinwirot University (Thailand)
VIT University (India)Auburn University (USA)University of Lodz (Poland)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
China Pharmacy2015, 26(27)J of Advanced Scientific R.2020, 11(3), p109-120.J Chromatogr Sci.2020, 58(6):485-493.Environ Toxicol.2019, 34(12):1354-1362J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123Int J Anal Chem.2017, 2017:1254721Korean J of Pharmacognosy2020, 51,49-54.Appl. Sci.2020, 10(8),2804J Nat Prod.2019, 82(4):1002-1008Nat Prod Commun.2014, 9(5):679-82
Related Screening Libraries
|| Momordicine I has anti-diabetic and antifeedant activities.|
|Planta Med. 2014 Jul;80(11):907-11. |
|Transport in Caco-2 cell monolayers of antidiabetic cucurbitane triterpenoids from Momordica charantia fruits.[Pubmed: 25116119]|
| Cucurbitane triterpenoids permeated to the basolateral side with apparent permeability coefficient (P app) values for 3-β-7-β,25-trihydroxycucurbita-5,23(E)-dien-19-al and Momordicine I and Momordicine II at 9.02 × 10(-6), 8.12 × 10(-6), and 1.68 × 10(-6)cm/s, respectively. Also, small amounts of these triterpenoids were absorbed inside the Caco-2 cells. This is the first report of the transport of the reputed antidiabetic cucurbitane triterpenoids in human intestinal epithelial cell monolayers. Our findings, therefore, further support the hypothesis that cucurbitane triterpenoids from bitter melon may explain, at least in part, the antidiabetic activity of this plant in vivo.|
|Phytomedicine. 2011 Dec 15;19(1):32-7. |
|Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro.[Pubmed: 22133295]|
|The antidiabetic activity of Momordica charantia (L.), Cucurbitaceae, a widely-used treatment for diabetes in a number of traditional medicine systems, was investigated in vitro. Antidiabetic activity has been reported for certain saponins isolated from M. charantia.
METHODS AND RESULTS:
In this study insulin secretion was measured in MIN6 β-cells incubated with an ethanol extract, saponin-rich fraction, and five purified saponins and cucurbitane triterpenoids from M. charantia, 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (1), Momordicine I (2), Momordicine II (3), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (4), and kuguaglycoside G (5). Treatments were compared to incubation with high glucose (27 mM) and the insulin secretagogue, glipizide (50 μM). At 125 μg/ml, an LC-ToF-MS characterized saponin-rich fraction stimulated insulin secretion significantly more than the DMSO vehicle, p=0.02. At concentrations 10 and 25 μg/ml, compounds 3 and 5 also significantly stimulated insulin secretion as compared to the vehicle, p≤0.007, and p=0.002, respectively.
This is the first report of a saponin-rich fraction, and isolated compounds from M. charantia, stimulating insulin secretion in an in vitro, static incubation assay.
Momordicine I Description
||The fruits of Momordica charantia
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Planta Med. 2010 Oct;76(15):1758-61. |
|Cucurbitane-type triterpenoids from Momordica charantia.[Pubmed: 20379957]|
METHODS AND RESULTS:
One new cucurbitane-type triterpenoid glycoside, momordicoside U (1), together with five known cucurbitane-type triterpenoids and related glycosides, 3β,7 β,25-trihydroxycucurbita-5,23 (E)-dien-19-al (2), Momordicine I (3), Momordicine II (4), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia.
Their structures were determined by chemical and spectroscopic methods. Momordicoside U (1) was evaluated for insulin secretion activity in an in vitro insulin secretion assay and displayed moderate activity.