| Structure Identification: |
| Tetrahedron, 1997, 53(13):4621-4626. | | Crystal and solution state conformations of two taxoids, taxinine and taxinine B[Reference: WebLink] |
METHODS AND RESULTS:
Crystal and solution state conformations of two taxoids, Taxinine and Taxinine B, inhibiting the drug transport by P-glycoprotein in multidrug-resistant cells, were analyzed by X-ray crystallographic analysis and ROE experiments. This study demonstrated that in solid state, both Taxinine and Taxinine B took similar cage conformation in which A-ring and the cinnamoyl side chain at C-ring were specially very close to each other.
CONCLUSIONS:
These conformations were also observed in their solution conformations deduced by ROE correlations in CDCl3, Monte Carlo simulation using MM2∗ force field, and semiempirical molecular orbital calculation using PM3 method. | | Natural Product Research & Development, 2004, 18(12):160-160. | | STUDIES ON CHEMICAL CONSTITUENTS OF SEEDS OF TUXUS MAIREI (Ⅰ)[Reference: WebLink] | | One sterol and nine taxane diterpenoids β-sitosterol(1),5α-cinnamoyloxy-9α,10β,13α-triacetoxy-taxa-4(20),11-diene(2),Taxinine(3),Taxinine J(4),Taxinine B(5),Taxinine E(6),10-deacetylTaxinine(7),taxuspine W(8),decinnamoylTaxinine E(9)and taxol(10)were isolated from the seeds of T.mairei.Except compounds 2,3,4,all the compounds were obtained from the seeds of this plant for the first time. |
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