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    Natural Products
    Tectol
    Tectol
    Information
    CAS No. 2449-39-6 Price $338 / 10mg
    Catalog No.CFN91054Purity>=98%
    Molecular Weight450.5Type of CompoundPhenols
    FormulaC30H26O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Tel: (0086)-27-84237683
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    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $219.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Tectol

    Tectol
    Product Name Tectol
    CAS No.: 2449-39-6
    Catalog No.: CFN91054
    Molecular Formula: C30H26O4
    Molecular Weight: 450.5 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Source: The herbs of Tectona grandis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $338 / 10mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

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    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Plant Methods.2017, 13:108
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Korean J Acupunct2020, 37:104-121
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Nat Prod Communications2018, 10.1177
  • Front Pharmacol.2016, 7:460
  • Int J Mol Sci.2020, 21(8):2790.
  • Sci Rep.2018, 8(1)
  • Metabolites.2020, 11(1):E11.
  • Phytochem Anal.2013, 24(5):493-503
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Phenols Compound Library
  • Biological Activity
    Description: Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatitis, the dermatitis appeared on the neck, upper legs, underarms, and trunk area.
    In vitro:
    J Nat Prod. 2001 Jun;64(6):792-5.
    Chemical constituents from Lippia sidoides and cytotoxic activity.[Pubmed: 11421746 ]

    METHODS AND RESULTS:
    Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone (13), were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3--13 were evaluated against HL60, SW1573, and CEM cell lines.
    CONCLUSIONS:
    Only Tectol (6) and lippsidoquinone (13) exhibited significant activity against human leukemia cell lines HL60 and CEM.
    In vivo:
    Contact Dermatitis. 1987 Aug;17(2):115-6.
    Allergy to spermicidal lubricant in a contraceptive.[Pubmed: 3652700 ]

    METHODS AND RESULTS:
    Allergic contact dermatitis is reported in a patient using a condom with the spermicidal lubricant Tectol. A 36 year old female, with no history of dermatitis or pruritus of the vagina or vulva, experienced itchy dermatitis 24-48 hours after her partner used a Durex Top Safe contraceptive containing Tectol. The dermatitis appeared on the neck, upper legs, underarms, and trunk area. When another contraceptive was used Durex Featherlite (without Tectol), the patient experienced no problems.
    CONCLUSIONS:
    Patch tests concluded that the Tectol lubricant was the cause for the reaction in the patient. Transmission of the lubricant to the patient occurred when the patient's partner, after handling the contraceptive (Durex Top Safe) during intercourse, placed his hands on the patient's body. To which exact element of Tectol the patient was sensitized could not be determined as the patient refused further treatment.
    Tectol Description
    Source: The herbs of Tectona grandis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2198 mL 11.0988 mL 22.1976 mL 44.3951 mL 55.4939 mL
    5 mM 0.444 mL 2.2198 mL 4.4395 mL 8.879 mL 11.0988 mL
    10 mM 0.222 mL 1.1099 mL 2.2198 mL 4.4395 mL 5.5494 mL
    50 mM 0.0444 mL 0.222 mL 0.444 mL 0.8879 mL 1.1099 mL
    100 mM 0.0222 mL 0.111 mL 0.222 mL 0.444 mL 0.5549 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Bioorg Med Chem. 2016 Jul 15;24(14):3102-7.
    Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors.[Pubmed: 27240468 ]
    Biological screening of a library of synthesized benzo[c]chromene-7,10-dione natural products against human farnesyltransferase (FTase) has identified tecomaquinone I (IC50 of 0.065±0.004μM) as being one of the more potent natural product inhibitors identified to date.
    METHODS AND RESULTS:
    Anti-plasmodial screening of the same library against a drug-resistant strain of Plasmodium falciparum identified the structurally-related dichromenol Tectol as a moderately active growth inhibitor with an IC50 3.44±0.20μM. Two novel series of analogues, based on the benzo[c]chromene-7,10-dione scaffold, were subsequently synthesized, with one analogue exhibiting farnesyltransferase inhibitory activity in the low micromolar range. A preliminary structure-activity relationship (SAR) study has identified different structural requirements for anti-malarial activity in comparison to FTase activities for these classes of natural products.
    CONCLUSIONS:
    Our results identify tecomaquinone I as a novel scaffold from which more potent inhibitors of human and parasitic FTase could be developed.
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