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    Natural Products
    Typhaneoside
    Information
    CAS No. 104472-68-6 Price $100 / 20mg
    Catalog No.CFN98146Purity>=98%
    Molecular Weight770.69Type of CompoundFlavonoids
    FormulaC34H42O20Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $55.9 / In-stock
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  • Biological Activity
    Description: Typhaneoside is possibly the main active component in the bioactive fraction of Shaofu Zhuyu decoction, Shaofu Zhuyu decoction may have direct inhibitory effects on the contractility of the mice uterus. It has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cells(HUASMC) with a wide range of effective dose but the effect is started slowly.
    In vitro:
    Journal of Beijing University of Traditional Chinese Medicine, 2006, 29(5):307-10.
    Influence of typhaneoside on proliferation of human umbilical arterial smooth muscle cells.[Reference: WebLink]
    To study the influence of Typhaneoside on the proliferation of human umbilical arterial smooth muscle cells(HUASMC).
    METHODS AND RESULTS:
    ① HUASMC were primary cultured with tissue-sticking method and determined by α-actin detection.The third to fourth generations of cells were put into the experiment.② The highest concentration of Typhaneoside was 1.00×10-5 mol/L and then diluted in multiple proportions into 11 concentration groups,and a blank control group was established.After the stimulations were given to different groups for 24,48 and 72 hours,the toxicity of Typhaneoside were detected with MTT assay.③ The highest concentration of Typhaneoside was 1.00×10-6 mol/L and then diluted in 1/4 isobaric proportion into 6 concentration groups,and a blank control group was established. After the stimulations were given to different groups for 24,48 and 72 hours,the influence of Typhaneoside on the proliferation of HUASMC was observed with MTT assay. ① The cellular staining was positive under the microscope.② Typhaneoside was not toxic to HUASMC in the concentration ranges from 9.77×10-9 mol/L to 1.00×10-5 mol/L after 24,48 and 72 hours.③ Typhaneoside did not inhibit the proliferation of HUASMC in the concentration ranges of 9.77×10-10 mol/L to 1.00×10-6 mol/L after 24 or 48 hours,but inhibited significantly the proliferation of HUASMC after 72 hours in the concentration ranges of 1.56×10-8 mol/L to 2.5×10-7 mol/L.The effect was increased along with the dose increase but there was no significant difference.The inhibitory rate reached 9.91% to 14.99%.
    CONCLUSIONS:
    Typhaneoside has an inhibitory effect on the proliferation of HUASMC with a wide range of effective dose but the effect is started slowly.
    In vivo:
    Am J Chin Med. 2010;38(4):777-87.
    Inhibitory effects of active fraction and its main components of Shaofu Zhuyu decoction on uterus contraction.[Pubmed: 20626062]
    Shaofu Zhuyu decoction is a famous formula for treating primary dysmenorrhea in China since the Qing dynasty. In this paper, the inhibitory effects of active-guided fraction and its main bioactive components of Shaofu Zhuyu decoction on a model of non-pregnant mice uterine contraction induced by oxytocin in vitro were investigated.
    METHODS AND RESULTS:
    Qualitative and quantitative chemical analyses were used to correlate the chemical composition of active fraction with the spasmolytic effects. Seven ingredients in the active fraction were identified and quantified by HPLC-DAD. Three ingredients, ferulic acid, vanillic acid, and Typhaneoside, were evaluated for their effects on mice isolated uterine contraction induced by oxytocin in vitro. The ED(50) of them were 63.0 microg/ml, 57.6 microg/ml, 109.7 microg/ml, respectively. Furthermore, the inhibitory activity of the combination of these three compounds was prior to the fraction and seven compounds group. The ED(50) was 65.5 microg/ml.
    CONCLUSIONS:
    The data stated that ferulic acid, vanillic acid, and Typhaneoside were possibly the main active components in the bioactive fraction of Shaofu Zhuyu decoction. The study also implied that Shaofu Zhuyu decoction may have direct inhibitory effects on the contractility of the mice uterus and justified the traditional use of the prescription for treating the uterine cramping associated dysmenorrhea.
    Typhaneoside Description
    Source: The herbs of Typha orientalis Presl.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2975 mL 6.4877 mL 12.9754 mL 25.9508 mL 32.4385 mL
    5 mM 0.2595 mL 1.2975 mL 2.5951 mL 5.1902 mL 6.4877 mL
    10 mM 0.1298 mL 0.6488 mL 1.2975 mL 2.5951 mL 3.2438 mL
    50 mM 0.026 mL 0.1298 mL 0.2595 mL 0.519 mL 0.6488 mL
    100 mM 0.013 mL 0.0649 mL 0.1298 mL 0.2595 mL 0.3244 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Pharm Biomed Anal. 2012 Nov;70:636-9.
    Determination of typhaneoside in rat plasma by liquid chromatography-tandem mass spectrometry.[Pubmed: 22818028]

    METHODS AND RESULTS:
    A highly sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of Typhaneoside in rat plasma using rutin as internal standard. The analyte and rutin (internal standard) were extracted with methanol followed by a rapid isocratic elution with 10 mM ammonium acetate buffer/methanol (v:v, 20:80) on an C(18) column (150 mm × 2.1 mm I.D.) and subsequent analysis by mass spectrometry in the multi-reaction-monitoring mode. The precursor to product ion transitions of m/z 769.3 → 314.1 and m/z 609.2 → 300.1 were used to measure the analyte and the internal standard. The assay was linear over the concentration range of 0.01-10 μg/mL for Typhaneoside in rat plasma. The lower limit of quantification was 0.01 μg/mL and the extraction recovery was larger than 90.2% for Typhaneoside.
    CONCLUSIONS:
    The inter- and intra-day precision of the method at three concentrations was less than 6.8%. The method was firstly applied to pharmacokinetic study of Typhaneoside in rats.