Vincamine | CAS:1617-90-9 | Manufacturer ChemFaces

Vincamine

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Size /Price /Stock	10 mM * 1 mL in DMSO / $10.8 / In-stock
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Description:

Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. Vincamine has contractile and relaxant actions on the guinea pig trachealis, may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution. Vincamine alleviates Amyloid-β 25-35 peptides-induced cytotoxicity in PC12 cells.

Targets:

Calcium Channel | Potassium Channel | Beta Amyloid | PI3K | Akt | SOD

In vitro:

Eur J Pharmacol. 1989 Mar 29;162(3):387-95.

Trachealis responses induced by vincamine and vinpocetine; inhibition by indomethacin and Ca2+ dependence.[Pubmed: 2744076]

METHODS AND RESULTS:
Vincamine in low concentrations induced a sustained contraction of the isolated guinea pig trachealis with long latency and slow onset and, in high concentrations, it induced relaxation which was potentiated in the precontracted trachealis. Vinpocetine had actions similar to those of Vincamine on trachealis, however its relaxant effect was more pronounced. The Vincamine-induced trachealis contraction was not changed by substance P desensitization, was reduced by tetrodotoxin, nifedipine and low Ca2+ high Mg2+ solution and increased in nominally Ca2+-free solution. The Vincamine-induced relaxation of precontracted trachealis was increased by guanethidine and was not affected by propranolol, high Mg2+-low Ca2+ solution and tetrodotoxin. Vincamine- and vinpocetine-induced trachealis contraction as well as vinpocetine-induced relaxation at basal tension were abolished by indomethacin. Vincamine in a low concentration shifted to the left the concentration-effect curve for CaCl2 in the K+-depolarized trachealis, and shifted it to the right at a high concentration.
CONCLUSIONS:
Our results indicate that the contractile and relaxant actions of Vincamine and vinpocetine on the guinea pig trachealis may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution.

Vincamine Description

Source:	The herbs of Catharanthus roseus (L.) G. Don.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Pharmacogn Mag. 2017 Jan-Mar;13(49):123-128.

Vincamine Alleviates Amyloid-β 25-35 Peptides-induced Cytotoxicity in PC12 Cells.[Pubmed: 28216895 ]

Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. The main purpose of the present study is to investigate the influence of Vincamine on amyloid-β 25-35 (Aβ25-35) induced cytotoxicity, to gain a better understanding of the neuroprotective effects of this clinically used anti-Alzheimer's disease drug.
METHODS AND RESULTS:
Oxidative stress was assessed by measuring malondialdehyde, glutathione, and superoxide dismutase (SOD) levels. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell apoptosis detection was performed using an Annexin-V-FITC Apoptosis Detection Kit. The production of reactive oxygen species (ROS) was determined using an ROS Assay Kit. Western blot detection was carried out to detect the protein expression. Our studies showed that pretreatment with Vincamine could reduce Aβ25-35 induced oxidative stress. Vincamine markedly inhibited cell apoptosis dose-dependently. More importantly, Vincamine increased the phosphatidylinositol-3 kinase (PI3K)/Akt and Bcl-2 family protein ratios on preincubation with cells for 2 h.
CONCLUSIONS:
Above observation led us to assume that one possible mechanism of Vincamine protects Aβ25-35-induced cell death could be through upregulation of SOD and activation of the PI3K/Akt pathway.Vincamine ameliorates amyloid-β 25-35 (Aβ25-35) peptides induced cytotoxicity in PC12 cellsVincamine reduces Aβ 25-35 peptides induced apoptosis of PC12 cellsVincamine activates the phosphatidylinositol-3 kinase/Akt pathwayVincamine up-regulates the superoxide dismutase.

Product Name	Vincamine
Price:	$40 / 20mg
CAS No.:	1617-90-9
Catalog No.:	CFN90464
Molecular Formula:	C₂₁H₂₆N₂O₃
Molecular Weight:	354.44 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The herbs of Catharanthus roseus (L.) G. Don.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Vasorelaxation Compound Library Bronchodilators Compound Library Alkaloids Compound Library SOD Inhibitor Library Potassium Channel Inhibitor Library PI3K Inhibitor Library Calcium Channel Inhibitor Library Beta Amyloid Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8214 mL	14.1068 mL	28.2135 mL	56.427 mL	70.5338 mL
5 mM	0.5643 mL	2.8214 mL	5.6427 mL	11.2854 mL	14.1068 mL
10 mM	0.2821 mL	1.4107 mL	2.8214 mL	5.6427 mL	7.0534 mL
50 mM	0.0564 mL	0.2821 mL	0.5643 mL	1.1285 mL	1.4107 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	0.5643 mL	0.7053 mL

CFN92747	Infractin	91147-07-8	254.3	C₁₅H₁₄N₂O₂
CFN99098	Harmalidine	109794-97-0	254.3	C₁₆H₁₈N₂O
CFN90499	Strictosidine	20824-29-7	530.57	C₂₇H₃₄N₂O₉
CFN96092	Harman	486-84-0	182.2	C₁₂H₁₀N₂
CFN92411	N9-Methylharman	16498-64-9	196.3	C₁₃H₁₂N₂
CFN92931	1-Methoxymethyl-beta-carboline	55854-60-9	212.25	C₁₃H₁₂N₂O
CFN96720	1-Hydroxymethyl-beta-carboline glucoside	1408311-12-5	360.36	C₁₈H₂₀N₂O₆
CFN91399	Tetrahydroharmine	17019-01-1	216.3	C₁₃H₁₆N₂O
CFN91136	Harmidol hydrochloride	6028-07-5	236.7	C₁₂H₁₃ClN₂O
CFN98385	Harmaline	304-21-2	214.3	C₁₃H₁₄N₂O