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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $14.4 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Institute of Food Science & Techn...2021...Natural Product Communications...2021...Korean J of Pharmacognosy...2020...BMC Complement Altern Med....2017...Korean Herb. Med. Inf....2020...Functional Ecology2020, doi: 10.1111.Clin Exp Pharmacol Physiol....2015...Front Pharmacol.2016, 7:460
J Herbmed Pharmacol.2018, 7(4):280-286Planta Med.2016, 82(13):1208-16J of Pharmaceutical Analysis...2020...Front Pharmacol.2017, 8:673Ulm University Medical Center...2020...Phytomedicine.2019, 56:48-56SCOPUS.2020, 836-847.Mol Med Rep.2014, 9(5):1653-9
Int J Mol Sci.2020, 21(19),7070.Pharmaceuticals (Basel)....2021...Life Sci.2021, 270:119074.J Chromatogr B Analyt Technol Bio...2019...LWT2020, 124:109163Front Pharmacol.2019, 10:1226Appl. Sci. 2021, 11(17),7829
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Our products had been exported to the following research institutions and universities, And still growing.
VIB Department of Plant Systems... (Belgium)University of British Columbia (Canada)Johannes Gutenberg University M... (Germany)Auburn University (USA)
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Vincamine
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Appl. Sci. 2021, 11(23),11099.Biosci Rep.2020, 40(8):BSR20201219.Sci Rep.2019, 9(1):4646Sci Rep. 2017, 17332(7)Evid Based Complement Alternat Med.2018, 2018:8565132Food and Bioprocess Technology2017, 10(6):1074-1092Onco Targets Ther.2017, 10:3467-3474Org Biomol Chem.2017, 15(31):6483-6492LWT-Food Sci Technol2020, 109163Pharmaceuticals (Basel).2021, 14(8):742.
Related Screening Libraries
| Description: |
Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. Vincamine has contractile and relaxant actions on the guinea pig trachealis, may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution. Vincamine alleviates Amyloid-β 25-35 peptides-induced cytotoxicity in PC12 cells. |
| Targets: |
Calcium Channel | Potassium Channel | Beta Amyloid | PI3K | Akt | SOD |
| In vitro: |
| Eur J Pharmacol. 1989 Mar 29;162(3):387-95. | | Trachealis responses induced by vincamine and vinpocetine; inhibition by indomethacin and Ca2+ dependence.[Pubmed: 2744076] |
METHODS AND RESULTS:
Vincamine in low concentrations induced a sustained contraction of the isolated guinea pig trachealis with long latency and slow onset and, in high concentrations, it induced relaxation which was potentiated in the precontracted trachealis. Vinpocetine had actions similar to those of Vincamine on trachealis, however its relaxant effect was more pronounced. The Vincamine-induced trachealis contraction was not changed by substance P desensitization, was reduced by tetrodotoxin, nifedipine and low Ca2+ high Mg2+ solution and increased in nominally Ca2+-free solution. The Vincamine-induced relaxation of precontracted trachealis was increased by guanethidine and was not affected by propranolol, high Mg2+-low Ca2+ solution and tetrodotoxin. Vincamine- and vinpocetine-induced trachealis contraction as well as vinpocetine-induced relaxation at basal tension were abolished by indomethacin. Vincamine in a low concentration shifted to the left the concentration-effect curve for CaCl2 in the K+-depolarized trachealis, and shifted it to the right at a high concentration.
CONCLUSIONS:
Our results indicate that the contractile and relaxant actions of Vincamine and vinpocetine on the guinea pig trachealis may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution. |
|
Vincamine Description
| Source: |
The herbs of Catharanthus roseus (L.) G. Don. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.8214 mL |
14.1068 mL |
28.2135 mL |
56.427 mL |
70.5338 mL |
| 5 mM |
0.5643 mL |
2.8214 mL |
5.6427 mL |
11.2854 mL |
14.1068 mL |
| 10 mM |
0.2821 mL |
1.4107 mL |
2.8214 mL |
5.6427 mL |
7.0534 mL |
| 50 mM |
0.0564 mL |
0.2821 mL |
0.5643 mL |
1.1285 mL |
1.4107 mL |
| 100 mM |
0.0282 mL |
0.1411 mL |
0.2821 mL |
0.5643 mL |
0.7053 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Cell Research: |
| Pharmacogn Mag. 2017 Jan-Mar;13(49):123-128. | | Vincamine Alleviates Amyloid-β 25-35 Peptides-induced Cytotoxicity in PC12 Cells.[Pubmed: 28216895 ] | Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. The main purpose of the present study is to investigate the influence of Vincamine on amyloid-β 25-35 (Aβ25-35) induced cytotoxicity, to gain a better understanding of the neuroprotective effects of this clinically used anti-Alzheimer's disease drug.
METHODS AND RESULTS:
Oxidative stress was assessed by measuring malondialdehyde, glutathione, and superoxide dismutase (SOD) levels. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell apoptosis detection was performed using an Annexin-V-FITC Apoptosis Detection Kit. The production of reactive oxygen species (ROS) was determined using an ROS Assay Kit. Western blot detection was carried out to detect the protein expression.
Our studies showed that pretreatment with Vincamine could reduce Aβ25-35 induced oxidative stress. Vincamine markedly inhibited cell apoptosis dose-dependently. More importantly, Vincamine increased the phosphatidylinositol-3 kinase (PI3K)/Akt and Bcl-2 family protein ratios on preincubation with cells for 2 h.
CONCLUSIONS:
Above observation led us to assume that one possible mechanism of Vincamine protects Aβ25-35-induced cell death could be through upregulation of SOD and activation of the PI3K/Akt pathway.Vincamine ameliorates amyloid-β 25-35 (Aβ25-35) peptides induced cytotoxicity in PC12 cellsVincamine reduces Aβ 25-35 peptides induced apoptosis of PC12 cellsVincamine activates the phosphatidylinositol-3 kinase/Akt pathwayVincamine up-regulates the superoxide dismutase. |
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