Vinleurosine | CAS:23360-92-1 | Manufacturer ChemFaces

Vinleurosine

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Description:

Vinleurosine can partially inhibit the energy dependent transport of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells.

In vitro:

J Cell Physiol. 1975 Oct;86(2 Pt 1):201-11.

A reduction in energy-dependent amino acid transport by microtubular inhibitors in Ehrlich ascites tumor cells.[Pubmed: 1194361]

Vincristine, other periwinkle alkaloids, and colchicine partially inhibit the energy dependent transport of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells. The properties of this phenomenon were characterized in detail for vincristine. Maximum depression of the steady-state intracellular alpha-aminoisobutyric acid level was achieved with a vincristine concentration of less than 0.5 muM. The inhibitory effect of vincristine increases as the extracellular alpha-aminoisobutyric acid concentration is increased reaching a maximum, however, of only approximately to 25% at a level of 5 mM, leaving a large gradient for alpha-aminoisobutyric acid across the cell membrane. Vincristine produced an asymmetrical uptake rate, while increasing the efflux of alpha-aminoisobutyric acid. Inhibition of net alpha-aminoisobutyric acid transport by vincristine was partially reversible (approximately to 40%). Colchicine (50 muM) reduced the steady-state alpha-aminoisobutyric acid level by 30%, an effect that was not reversible. Inhibition by Vinleurosine and vinrosidine was comparable to that of vincristine. Addition of glucose to the medium resulted in a small, but significant, decrease in the inhibitory effects of both vincristine and colchicine. The data indicate that these agents inhibit a small component of the uphill transport of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells. The inhibitory effect of vincristine cannot be attributed to an increase in the passive permeability of the cell membrane to this agent. Rather, the data along with other studies from this laboratory suggest that vincristine reduces the energy-dependent transport of alpha-aminoisobutyric acid by either inhibiting cellular energy metabolism or by inhibiting cellular energy metabolism or by inhibiting the coupling of energy-metabolism to the transport of this amino acid and raises the possibility that cellular microtubules play a role in these processes.

Vinleurosine Description

Source:	The herbs of Catharanthus roseus (L.) G. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vinleurosine
Price:
CAS No.:	23360-92-1
Catalog No.:	CFN90466
Molecular Formula:	C₄₆H₅₆N₄O₉
Molecular Weight:	808.95 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The herbs of Catharanthus roseus (L.) G. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2362 mL	6.1809 mL	12.3617 mL	24.7234 mL	30.9043 mL
5 mM	0.2472 mL	1.2362 mL	2.4723 mL	4.9447 mL	6.1809 mL
10 mM	0.1236 mL	0.6181 mL	1.2362 mL	2.4723 mL	3.0904 mL
50 mM	0.0247 mL	0.1236 mL	0.2472 mL	0.4945 mL	0.6181 mL
100 mM	0.0124 mL	0.0618 mL	0.1236 mL	0.2472 mL	0.309 mL

CFN90142	Vinorelbine Tartrate	125317-39-7	1079.11	C₅₃H₆₆N₄O₂₀
CFN90146	Vinblastine Sulfate	143-67-9	909.06	C₄₆H₅₈N₄O₉.H₂SO₄
CFN90230	Vinblastine	865-21-4	810.96	C₄₆H₅₈N₄O₉
CFN90246	3',4'-Anhydrovinblastine	38390-45-3	792.96	C₄₆H₅₆N₄O₈
CFN90400	Vincristine sulfate	2068-78-2	923.04	C₄₆H₅₈N₄O₁₄S
CFN90401	Vinorelbine	71486-22-1	778.93	C₄₅H₅₄N₄O₈
CFN90465	Vindesine	53643-48-4	753.92	C₄₃H₅₅N₅O₇
CFN90466	Vinleurosine	23360-92-1	808.95	C₄₆H₅₆N₄O₉
CFN98589	Vincristine	57-22-7	824.96	C₄₆H₅₆N₄O₁₀